DE-RISKING METABOLIC, ENVIRONMENTAL AND BEHAVIORAL DETERMINANTS OF OBESITY IN CHILDREN, ADOLESCENTS AND YOUNG ADULTS

Informations projet

PAS GRAS

N° de convention de subvention: 101080329

DOI

10.3030/101080329

Date de signature de la CE 28 Avril 2023

Date de début 1 Mai 2023

Date de fin 30 Avril 2028

Financé au titre de

• Health

Coût total

€ 9 377 421,25

Contribution de l’UE

€ 9 377 421,25

Coordonné par

UNIVERSIDADE DE COIMBRA
Portugal

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (5)

First PDEC version

First version of all actions for DC&E

First version of the Education and Training plan

A document stating all training and education activities across the consortium will be prepared.

Study initiation package

Report detailing the pre-registration (clinicaltrial.gov) of the clinical trial (WP5), final protocol and ethical issues

Pre-registration of animal studies

Report with the pre-registration of in vivo assays (including previous in vitro data)

Report from Kick-Off meeting

A report will be produced, including the compositionof the different boards

Data Management Plan (1)

Data management plan

A data management plan will be prepared by allpartners. Updated whenever necessary

Websites, patent fillings, videos etc. (2)

Project Website

Public website

Project social media

Report on PAS GRAS social media

Publications

Peer reviewed articles (38)

Autophagy alterations in obesity, type 2 diabetes, and metabolic dysfunction-associated steatotic liver disease: the evidence from human studies

Auteurs: Patrycja Jakubek, Barbara Pakula, Martin Rossmeisl, Paolo Pinton, Alessandro Rimessi, Mariusz Roman Wieckowski
Publié dans: Internal and Emergency Medicine, Numéro 19, 2024, ISSN 1828-0447
Éditeur: Springer Science and Business Media LLC
DOI: 10.1007/s11739-024-03700-w

The role of <scp>CD20</scp>⁺ T cells: Insights in human peripheral blood

Auteurs: Aryane Cruz Oliveira Pinho, Pedro Barbosa, Maria Joo Pereira, Artur Paiva, Eugenia Carvalho, Paula Laranjeira
Publié dans: Cytometry Part B: Clinical Cytometry, Numéro 106, 2024, ISSN 1552-4949
Éditeur: Wiley
DOI: 10.1002/cyto.b.22178

Metabolic dysfunction-associated steatotic liver disease: Evolution of the final terminology

Auteurs: Piero Portincasa, Gyorgy Baffy
Publié dans: European Journal of Internal Medicine, Numéro 124, 2024, ISSN 0953-6205
Éditeur: Elsevier BV
DOI: 10.1016/j.ejim.2024.04.013

Short-term effects of obesity surgery versus low-energydiet on body composition and tissue-specific glucose uptake: a randomised clinical study using whole-body integrated 18F-FDG-PET/MRI

Auteurs: Jan W. Eriksson, Maria J. Pereira, Christakis Kagios, Sofia Kvernby, Elin Lundstrm, Giovanni Fanni, Martin H. Lundqvist, Bjrn C. L. Carlsson, Magnus Sundbom, Sambit Tarai, Mark Lubberink, Joel Kullberg, Ulf Risrus, Hkan Ahlstrm
Publié dans: Diabetologia, Numéro 67, 2024, ISSN 0012-186X
Éditeur: Springer Science and Business Media LLC
DOI: 10.1007/s00125-024-06150-3

Characterizing Early Cardiac Metabolic Programming via 30% Maternal Nutrient Reduction during Fetal Development in a Non-Human Primate Model

Auteurs: Susana P. Pereira, Mariana S. Diniz, Ludgero C. Tavares, Teresa Cunha-Oliveira, Cun Li, Laura A. Cox, Mark J. Nijland, Peter W. Nathanielsz, Paulo J. Oliveira
Publié dans: International Journal of Molecular Sciences, Numéro 24, 2023, ISSN 1422-0067
Éditeur: MDPI AG
DOI: 10.3390/ijms242015192

Metabolomic Profiling of Adipose Tissue in Type 2 Diabetes: Associations with Obesity and Insulin Resistance

Auteurs: Argyri Mathioudaki, Giovanni Fanni, Jan W. Eriksson, Maria J. Pereira
Publié dans: Metabolites, Numéro 14, 2024, ISSN 2218-1989
Éditeur: MDPI AG
DOI: 10.3390/metabo14080411

Metabolic Derangement of Essential Transition Metals and Potential Antioxidant Therapies

Auteurs: Adriana Fontes, Adrian T. Jauch, Judith Sailer, Jonas Engler, Anabela Marisa Azul, Hans Zischka
Publié dans: International Journal of Molecular Sciences, Numéro 25, 2024, ISSN 1422-0067
Éditeur: MDPI AG
DOI: 10.3390/ijms25147880

What are we missing to gain the battle against cardiovascular diseases?

Auteurs: Harshitha Shanmugam, Piero Portincasa, Agostino Di Ciaula
Publié dans: European Heart Journal, Numéro 45, 2024, ISSN 0195-668X
Éditeur: Oxford University Press (OUP)
DOI: 10.1093/eurheartj/ehae279

Identification and characterization of circulating and adipose tissue infiltrated CD20+ T cells from subjects with obesity that undergo bariatric surgery

Auteurs: Aryane Cruz Oliveira Pinho, Pedro Barbosa, Andr Lazaro, Jos G. Tralho, Maria Joo Pereira, Artur Paiva, Paula Laranjeira, Eugenia Carvalho
Publié dans: Immunology Letters, Numéro 269, 2024, ISSN 0165-2478
Éditeur: Elsevier BV
DOI: 10.1016/j.imlet.2024.106911

Nutritional and Physiological Properties of Thymbra spicata: In Vitro Study Using Fecal Fermentation and Intestinal Integrity Models

Auteurs: Mohamad Khalil, Francesca Piccapane, Mirco Vacca, Giuseppe Celano, Laura Mahdi, Valeria Perniola, Carmen Aurora Apa, Alessandro Annunziato, Ilaria Iacobellis, Giuseppe Procino, Maria Calasso, Maria De Angelis, Rosa Caroppo, Piero Portincasa
Publié dans: Nutrients, Numéro 16, 2024, ISSN 2072-6643
Éditeur: MDPI AG
DOI: 10.3390/nu16050588

The interaction of bile acids and gut inflammation influences the pathogenesis of inflammatory bowel disease

Auteurs: Agostino Di Ciaula, Leonilde Bonfrate, Mohamad Khalil, Piero Portincasa
Publié dans: Internal and Emergency Medicine, Numéro 18, 2023, ISSN 1828-0447
Éditeur: Springer Science and Business Media LLC
DOI: 10.1007/s11739-023-03343-3

Nurturing through Nutrition: Exploring the Role of Antioxidants in Maternal Diet during Pregnancy to Mitigate Developmental Programming of Chronic Diseases

Auteurs: Mariana S. Diniz, Carina C. Magalhes, Carolina Tocantins, Lus F. Grilo, Jos Teixeira, Susana P. Pereira
Publié dans: Nutrients, Numéro 15, 2023, ISSN 2072-6643
Éditeur: MDPI AG
DOI: 10.3390/nu15214623

Converging Pathways between Metabolic DysfunctionAssociated Steatotic Liver Disease (MASLD) and Diabetes in Children

Auteurs: Maria Felicia Faienza, Ilaria Farella, Mohamad Khalil, Piero Portincasa
Publié dans: International Journal of Molecular Sciences, Numéro 25, 2024, ISSN 1422-0067
Éditeur: MDPI AG
DOI: 10.3390/ijms25189924

Fetoplacental endothelial dysfunction in gestational diabetes mellitus and maternal obesity: A potential threat for programming cardiovascular disease

Auteurs: Mariana S. Diniz, Ursula Hiden, Ins Falco-Pires, Paulo J. Oliveira, Luis Sobrevia, Susana P. Pereira
Publié dans: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Numéro 1869, 2024, ISSN 0925-4439
Éditeur: Elsevier BV
DOI: 10.1016/j.bbadis.2023.166834

Made in the Womb: Maternal Programming of Offspring Cardiovascular Function by an Obesogenic Womb

Auteurs: Mariana S. Diniz, Luís F. Grilo, Carolina Tocantins, Inês Falcão-Pires, Susana P. Pereira
Publié dans: Metabolites, Numéro 13, 2025, ISSN 2218-1989
Éditeur: MDPI AG
DOI: 10.3390/metabo13070845

Mitochondrial Dysfunction in Endothelial Progenitor Cells: Unraveling Insights from Vascular Endothelial Cells

Auteurs: Azra Kulovic-Sissawo, Carolina Tocantins, Mariana S. Diniz, Elisa Weiss, Andreas Steiner, Silvija Tokic, Corina T. Madreiter-Sokolowski, Susana P. Pereira, Ursula Hiden
Publié dans: Biology, Numéro 13, 2024, ISSN 2079-7737
Éditeur: MDPI AG
DOI: 10.3390/biology13020070

Advances in the pathophysiology, diagnosis and management of chronic diarrhoea from bile acid malabsorption: a systematic review

Auteurs: Agostino Di Ciaula, Mohamad Khalil, Gyorgy Baffy, Piero Portincasa
Publié dans: European Journal of Internal Medicine, Numéro 128, 2024, ISSN 0953-6205
Éditeur: Elsevier BV
DOI: 10.1016/j.ejim.2024.07.008

Clinical and molecular profiling of human visceral adipose tissue reveals impairment of vascular architecture and remodeling as an early hallmark of dysfunction

Auteurs: Daniela Rosendo-Silva, Pedro Bastos Gomes, Tiago Rodrigues, Sofia Viana, Andr Nogueira da Costa, Philipp E. Scherer, Flvio Reis, Francisco Pereira, Raquel Seia, Paulo Matafome
Publié dans: Metabolism, Numéro 153, 2024, ISSN 0026-0495
Éditeur: Elsevier BV
DOI: 10.1016/j.metabol.2024.155788

Hepatic glucose metabolism in the steatotic liver

Auteurs: Egeria Scoditti, Silvia Sabatini, Fabrizia Carli, Amalia Gastaldelli
Publié dans: Nature Reviews Gastroenterology &amp; Hepatology, Numéro 21, 2024, ISSN 1759-5045
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/s41575-023-00888-8

Maternal hepatic adaptations during obese pregnancy encompass lobe-specific mitochondrial alterations and oxidative stress

Auteurs: LusF. Grilo, JooD. Martins, MarianaS. Diniz, Carolina Tocantins, ChiaraH. Cavallaro, Ins Baldeiras, Teresa Cunha-Oliveira, Stephen Ford, PeterW. Nathanielsz, PauloJ. Oliveira, SusanaP. Pereira
Publié dans: Clinical Science, Numéro 137, 2023, ISSN 0143-5221
Éditeur: Portland Press Ltd.
DOI: 10.1042/CS20230048

Mitochondrial DNA – novel mechanisms of kidney damage and potential biomarker

Auteurs: Afshan N. Malik
Publié dans: Current Opinion in Nephrology &amp; Hypertension, Numéro 32, 2024, ISSN 1062-4821
Éditeur: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1097/mnh.0000000000000922

Adipose tissue-liver cross-talk: a route to hepatic dysfunction in pregnant women with obesity

Auteurs: Diana Sousa, CarinaC. Magalhes, Paulo Matafome, SusanaP. Pereira
Publié dans: Bioscience Reports, Numéro 44, 2024, ISSN 0144-8463
Éditeur: Portland Press Ltd.
DOI: 10.1042/BSR20231679

Co-regulation and synteny of GFM2 and NSA2 links ribosomal function in mitochondria and the cytosol with chronic kidney disease

Auteurs: Minjie Zhang, Christer Hogstrand, Paola Pontrelli, Afshan N Malik
Publié dans: Molecular Medicine, Numéro 30, 2024, ISSN 1528-3658
Éditeur: Springer Science and Business Media LLC
DOI: 10.1186/s10020-024-00930-8

Metabolic dysfunction-associated gallstone disease: expecting more from critical care manifestations

Auteurs: Piero Portincasa, Agostino Di Ciaula, Leonilde Bonfrate, Alessandro Stella, Gabriella Garruti, John Thomas Lamont
Publié dans: Internal and Emergency Medicine, Numéro 18, 2023, ISSN 1828-0447
Éditeur: Springer Science and Business Media LLC
DOI: 10.1007/s11739-023-03355-z

Metabolic Dysfunction–Associated Steatotic Liver Disease: From Pathogenesis to Current Therapeutic Options

Auteurs: Piero Portincasa, Mohamad Khalil, Laura Mahdi, Valeria Perniola, Valeria Idone, Annarita Graziani, Gyorgy Baffy, Agostino Di Ciaula
Publié dans: International Journal of Molecular Sciences, Numéro 25, 2024, ISSN 1422-0067
Éditeur: MDPI AG
DOI: 10.3390/ijms25115640

Renal sinus adipose tissue: exploratory study of metabolic features and transcriptome compared with omental and subcutaneous adipose tissue

Auteurs: Maria J. Pereira, Argyri Mathioudaki, Alicia G. Otero, Padma Priya Duvvuri, Milica Vranic, Amir Sedigh, Jan W. Eriksson, Maria K. Svensson
Publié dans: Obesity, Numéro 32, 2024, ISSN 1930-7381
Éditeur: Wiley
DOI: 10.1002/oby.24114

Cardiac Molecular Analysis Reveals Aging‐Associated Metabolic Alterations Promoting Glycosaminoglycans Accumulation via Hexosamine Biosynthetic Pathway

Auteurs: Luís F. Grilo, Kip D. Zimmerman, Sobha Puppala, Jeannie Chan, Hillary F. Huber, Ge Li, Avinash Y. L. Jadhav, Benlian Wang, Cun Li, Geoffrey D. Clarke, Thomas C. Register, Paulo J. Oliveira, Peter W. Nathanielsz, Michael Olivier, Susana P. Pereira, Laura A. Cox
Publié dans: Advanced Science, Numéro 11, 2024, ISSN 2198-3844
Éditeur: Wiley
DOI: 10.1002/advs.202309211

Corrigendum to “The adipose tissue melanocortin 3 receptor is targeted by ghrelin and leptin and may be a therapeutic target in obesity” [Mol. Cell. Endocrinol. 594 (2024), 112367]

Auteurs: Daniela Rosendo-Silva, Eduardo Lopes, Tamaeh Monteiro-Alfredo, Inês Falcão-Pires, Hans Eickhoff, Sofia Viana, Flávio Reis, Ana Salomé Pires, Ana Margarida Abrantes, Maria Filomena Botelho, Raquel Seiça, Paulo Matafome
Publié dans: Molecular and Cellular Endocrinology, Numéro 595, 2024, ISSN 0303-7207
Éditeur: Elsevier BV
DOI: 10.1016/j.mce.2024.112410

Distinct biophysiological effects of Ramadan fasting and traditional intermittent fasting on markers of body fat storage. A real-life study

Auteurs: Mohamad Khalil, Hala Abdallah, Nour Jaber, Gabriella Garruti, Agostino Di Ciaula, Piero Portincasa
Publié dans: European Journal of Internal Medicine, Numéro 129, 2024, ISSN 0953-6205
Éditeur: Elsevier BV
DOI: 10.1016/j.ejim.2024.08.014

Maternal heart exhibits metabolic and redox adaptations post-uncomplicated pregnancy

Auteurs: Carolina Tocantins, Joo D. Martins, scar M. Rodrigues, Lus F. Grilo, Mariana S. Diniz, Jelena Stevanovic-Silva, Jorge Beleza, Pedro Coxito, David Rizo-Roca, Estela Santos-Alves, Antnio J. Moreno, Antnio Ascenso, Jos Magalhes, Paulo J. Oliveira, Susana P. Pereira
Publié dans: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Numéro 1871, 2024, ISSN 0925-4439
Éditeur: Elsevier BV
DOI: 10.1016/j.bbadis.2024.167539

The adipose tissue melanocortin 3 receptor is targeted by ghrelin and leptin and may be a therapeutic target in obesity

Auteurs: Daniela Rosendo-Silva, Eduardo Lopes, Tamaeh Monteiro-Alfredo, Ins Falco-Pires, Hans Eickhoff, Sofia Viana, Flvio Reis, Ana Salom Pires, Ana Margarida Abrantes, Maria Filomena Botelho, Raquel Seia, Paulo Matafome
Publié dans: Molecular and Cellular Endocrinology, Numéro 594, 2024, ISSN 0303-7207
Éditeur: Elsevier BV
DOI: 10.1016/j.mce.2024.112367

Lipid metabolism in MASLD and MASH: From mechanism to the clinic

Auteurs: Fabrizia Carli, Giuseppe Della Pepa, Silvia Sabatini, Antonio Vidal Puig, Amalia Gastaldelli
Publié dans: JHEP Reports, Numéro 6, 2024, ISSN 2589-5559
Éditeur: Elsevier BV
DOI: 10.1016/j.jhepr.2024.101185

Oxidative stress in metabolic dysfunctionassociated steatotic liver disease (<scp>MASLD</scp>): How does the animal model resemble human disease?

Auteurs: Patrycja Jakubek, Piotr Kalinowski, Agnieszka KarkucinskaWieckowska, Aakruti Kaikini, Ins C. M. Simes, Yaiza Potes, Beata Kruk, Wieslawa Grajkowska, Paolo Pinton, Piotr Milkiewicz, Micha Grt, Maciej Pronicki, Magdalena LebiedzinskaArciszewska, Marcin Krawczyk, Mariusz R. Wieckowski
Publié dans: The FASEB Journal, Numéro 38, 2024, ISSN 0892-6638
Éditeur: Wiley
DOI: 10.1096/fj.202302447R

Multidimensional Assessment of Sarcopenia and Sarcopenic Obesity in Geriatric Patients: Creatinine/Cystatin C Ratio Performs Better than Sarcopenia Index

Auteurs: Mohamad Khalil, Agostino Di Ciaula, Nour Jaber, Roberta Grandolfo, Flavia Fiermonte, Piero Portincasa
Publié dans: Metabolites, Numéro 14, 2024, ISSN 2218-1989
Éditeur: MDPI AG
DOI: 10.3390/metabo14060306

Increased OCT3 Expression in Adipose Tissue With Aging: Implications for Catecholamine and Lipid Turnover and Insulin Resistance in Women

Auteurs: Fozia Ahmed, Milica Vranic, Susanne Hetty, Argyri Mathioudaki, Vagia Patsoukaki, Giovanni Fanni, Maria J Pereira, Jan W Eriksson
Publié dans: Endocrinology, Numéro 165, 2023, ISSN 1945-7170
Éditeur: The Endocrine Society
DOI: 10.1210/endocr/bqad172

Gut microbes in metabolic disturbances. Promising role for therapeutic manipulations?

Auteurs: Piero Portincasa, Mohamad Khalil, Annarita Graziani, Gema Frhbeck, Gyorgy Baffy, Gabriella Garruti, Agostino Di Ciaula, Leonilde Bonfrate
Publié dans: European Journal of Internal Medicine, Numéro 119, 2024, ISSN 0953-6205
Éditeur: Elsevier BV
DOI: 10.1016/j.ejim.2023.10.002

Metabolic mitochondrial alterations prevail in the female rat heart 8weeks after exercise cessation

Auteurs: Carolina Tocantins, Joo D. Martins, scar M. Rodrigues, Lus F. Grilo, Mariana S. Diniz, Jelena StevanovicSilva, Jorge Beleza, Pedro Coxito, David RizoRoca, Estela SantosAlves, Manoel Rios, Lina Carvalho, Antnio J. Moreno, Antnio Ascenso, Jos Magalhes, Paulo J. Oliveira, Susana P. Pereira
Publié dans: European Journal of Clinical Investigation, Numéro 53, 2023, ISSN 0014-2972
Éditeur: Wiley
DOI: 10.1111/eci.14069

Proteomic Profiling of Plasma- and Gut-Derived Extracellular Vesicles in Obesity

Auteurs: Pedro Baptista Pereira, Estefania Torrejón, Inês Ferreira, Ana Sofia Carvalho, Akiko Teshima, Inês Sousa-Lima, Hans Christian Beck, Bruno Costa-Silva, Rune Matthiesen, Maria Paula Macedo, Rita Machado de Oliveira
Publié dans: Nutrients, Numéro 16, 2024, ISSN 2072-6643
Éditeur: MDPI AG
DOI: 10.3390/nu16050736

Book chapters (1)

Absolute Quantification of Cellular and Cell-Free Mitochondrial DNA Copy Number from Human Blood and Urinary Samples Using Real Time Quantitative PCR

Auteurs: Eliane Caseiro Soares de Menezes, Afshan Navid Malik
Publié dans: Methods in Molecular Biology, Mitochondrial Bioenergetics, 2024
Éditeur: Springer US
DOI: 10.1007/978-1-0716-4264-1_13