Work Package 1 (WP1) Patient involvement and user centric approach
Conducted meetings with hospitals and Nora to gather insights into patient experiences and hospital ecosystems.
Developed a patient matrix with five different profiles based on engagement and mobile technology usage.
Conducted workshops to validate findings and created a comprehensive patient journey map outlining phases such as diagnosis, hospitalization, discharge, and post-stroke care.
Designed a visual prototype of the solution ahead of schedule, validated by stroke patients.
Work Package 2 (WP2) Federated infrastructure
Gathered requirements, developed a modular FL platform, and validated its operational functionality.
Defined secure and efficient network architecture using Docker for client nodes.
Designed and optimized FL algorithms, validated with stress tests using public datasets.
Conducted threat and risk assessments for FL infrastructure, addressing vulnerabilities through penetration testing.
Implemented MQTT for FL process management and aligned PaaS functions with IEEE standards.
Work Package 3 (WP3) Data management, trustworthiness and bias
Created a Data Management Plan (DMP) to ensure FAIR and TRUST principles.
Delayed access to VHIR data postponed some tasks, but initial data exploration and Clinical Data Model (CDM) design were completed.
Conducted statistical analyses and developed a Python toolbox for data harmonization.
Prepared AI-ready datasets for stroke analysis and assessed data trustworthiness and bias in line with global ethical standards.
Work Package 4 (WP4) Trustworthy AI models
Established trustworthiness parameters and a prototype repository for data management.
Integrated explainable AI methods (e.g. SHAP, LIME) for stroke outcome prediction, assessing their practicality and effectiveness.
Deployed computational infrastructure for AI model training, addressing delays in server installation at one clinical site.
Developed initial AI models for predictive endpoints, integrated with NORA via a REST API.
Work Package 5 (WP5) TRUSTroke platform integration and patient empowerment
Implemented PROMs and PREMs questionnaires, integrated into a federated software architecture via NORA.
Conducted multilingual translations of the NORA app and ensured secure data routing through a VPN.
Refined the app's design and functionalities, presenting it on AI Appreciation Day for dissemination.
Work Package 6 (WP6) Clinical proof of concept study and contribution to clinical guidelines
Identified clinical parameters for predictive models and finalized retrospective study protocols.
Negotiated data processing agreements and prepared prospective study protocols, including IT infrastructure development for NORA.
Addressed delays in patient recruitment due to ethics committee approvals.
Work Package 7 (WP7) Regulatory acceptability, Exploitation and Sustainability
Established an Ethical Internal Board (EIB) and implemented an Ethics Management Plan.
Created an inventory of intellectual property, analyzing patents and competitive landscapes.
Developed a CE marking roadmap and initiated Health Technology Assessment (HTA) processes.
Work Package 8 (WP8) Project Management, Communication, Dissemination & Open Science
Delivered the Project Management Plan, Evaluation Plan, and Open Science framework on schedule.
Conducted technical reviews, monthly consortium, Executive board, C&D and General Assembly meetings for collaborative alignment.
Launched the project website, social media platforms, and dissemination kits, promoting stakeholder engagement.
Organized webinars to support open science practices and foster knowledge sharing.
