Descripción del proyecto
Dirigir los esfuerzos de creación de una vacuna contra el paludismo eficaz para diferentes especies de parásitos
«Plasmodium vivax» es una especie de protozoo parásito que causa una forma menos grave de paludismo que «Plasmodium falciparum». «P. vivax» tiene la capacidad única de formar estadios hepáticos latentes responsables de la recidiva meses o incluso años después de la infección inicial, y su prevalencia generalizada es motivo de grave preocupación. El proyecto OptiViVax, financiado por el programa Horizonte Europa, pretende acelerar la investigación y el desarrollo de vacunas de nueva generación utilizando métodos innovadores. Sus investigadores tienen previsto ampliar la cartera de antígenos para ensayos clínicos y examinar nuevas plataformas de administración y adyuvantes. El conocimiento de los mecanismos de protección mediada por anticuerpos, junto con los avances en la investigación y las herramientas clínicas, contribuirán a un diseño óptimo de vacunas.
Objetivo
Plasmodium vivax is the most widespread human malaria with 2.5 billion people living at risk in South America, Oceania and Asia. The revised Malaria Vaccine Technology Roadmap to 2030 recognises the severity of P. vivax malaria, calling for a vaccine intervention to achieve 75% efficacy over two years, now equally weighted with P. falciparum. However, if this ambition is to be realised, new and innovative approaches are urgently required to accelerate next-generation vaccine research and development, whilst the few known candidate antigens need to undergo early-phase clinical assessment.
Here, we build on exciting breakthroughs in P. vivax vaccine research, recently pioneered in Europe, including new transgenic parasite technologies for functional assay development and production of a parasite clone that is safe for use in controlled human malaria infection (CHMI) clinical models. The Objectives of OptiViVax will now integrate ambitious multi-disciplinary scientific and clinical approaches around the parasite’s lifecycle and will use our increased knowledge of P. vivax immuno-biology to further develop next-generation vaccines with improved efficacy. We will diversify the portfolio of new antigens ready for clinical testing by reverse vaccinology and diversify their delivery with new platforms and adjuvants developed using sustainable and improved GMP bio-manufacturing know-how. In parallel, the efficacy of known leading antigens will be benchmarked for the first time using innovative design of clinical studies and CHMI models making these lead candidate vaccines ready for future field trials. Improved preclinical functional assays, using state-of-the-art transgenic parasite lines, will also allow for mechanisms of antibody-mediated protection to be deciphered. The availability of new functional assays and human challenge models will underpin the future framework for informed decision making by the clinical vaccine community, policy makers, funders and regulators.
Ámbito científico
Palabras clave
Programa(s)
Convocatoria de propuestas
HORIZON-HLTH-2022-DISEASE-06-two-stage
Consulte otros proyectos de esta convocatoriaRégimen de financiación
HORIZON-RIA - HORIZON Research and Innovation ActionsCoordinador
6525 GA Nijmegen
Países Bajos