Description du projet
Des applications biomédicales innovantes des nanomatériaux MXènes
Les MXènes sont une nouvelle famille de carbures, carbonitrures et nitrures de métaux de transition 2D, récemment découverts. La caractérisation immunitaire des nouveaux matériaux, basée sur leurs propriétés physico-chimiques et immunologiques, ouvrira des perspectives pour le développement de nouvelles applications thérapeutiques des nanomatériaux dans l’ingénierie tissulaire, dans les thérapies anticancéreuses, ainsi qu’en tant qu’agents antibactériens et immunomodulateurs. Financé par le programme Actions Marie Skłodowska-Curie, le projet MX-MAP développera des stratégies essentielles pour les applications médicales des MXènes. L’objectif à long terme de MX-MAP consiste à créer un pipeline faisant appel à de nouveaux nanomatériaux MXènes pour l’évaluation qualitative et quantitative de la compatibilité immunologique dans les applications biomédicales. Ce programme international de recherche/formation a pour ambition de soutenir le développement de la carrière de jeunes chercheurs avec une vision interdisciplinaire de la science.
Objectif
The long-term goal of MX-MAP is to develop a functional pipeline for the immune characterization of new 2D nanomaterials of MXene family, for the qualitative and quantitative assessment of the human immune compatibility and immune activity towards biomedical applications.
The immune characterization of the tested materials on the basis of intrinsic physical-chemical and immunological properties, through the combination of the most innovative technologies such as single-cell mass cytometry (CyTOF), will open breakthrough perspectives for the development of new therapeutic approaches applying nanomaterials as immunomodulators, scaffolds for tissue engineering, cancer therapy, and antibacterial agents. MX-MAP will develop key chemistry and immune-based strategies for MXene medical applications. The implication of this project extends beyond the specific nanoscience program greatly advancing the engineering process of 2D materials and their use in biomedicine.
The MX-MAP project involves fourteen key players in European and non-European countries, including the United States, Canada, Saudi Arabia, and three partners from Ukraine, coming from academia and SMEs.
This program will provide strong support for the development of the careers of young brilliant scientists who want to grow towards an interdisciplinary vision of Science.
Chemistry, biology, immunology, engineering, and cancer research are the expertise of MX-MAP. The senior team members are among the most influential scientists, including Prof. Yury Gogotsi (H-index=168) - inventor of MXenes, Prof. Klaus Ley (H-index=147) - one of the most cited immunologists worldwide, and Prof. Husam N Alshareef (H-index=99). The Consortium is perfectly balanced in terms of equal gender presence; the project Coordinator Lucia Gemma Delogu is a female, and 2 out 4 of four WP leaders are female. The project embraces a large view of inclusiveness and diversity, including countries with smaller economies such as Ukraine.
Champ scientifique
Mots‑clés
Programme(s)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Régime de financement
HORIZON-TMA-MSCA-SE - HORIZON TMA MSCA Staff ExchangesCoordinateur
35122 Padova
Italie