Description du projet
Évaluation de l’efficacité cytotoxique et catalytique de nouveaux complexes métalliques
Le projet MET-EFFECT, financé par le MSCA, se propose de développer de nouveaux complexes multifonctionnels de rhénium (Re) et d’iridium (Ir) pour la conception de métallo-médicaments. Les chercheurs concevront des complexes de Re et d’Ir contenant des ligands de type apigénine, une molécule naturelle bioactive de type flavone. Le potentiel antitumoral des complexes sera testé sur un panel de diverses lignées cellulaires cancéreuses humaines. Les chercheurs évalueront en outre l’utilisation potentielle des complexes Re(V) nouvellement synthétisés en tant que catalyseurs homogènes dans les réactions d’époxydation des oléfines, de réduction catalytique des oxoanions et d’oxydation de l’eau.
Objectif
The immense power of practice-oriented synthetic chemistry is demonstrated through the opportunity to design, synthesize, optimize, produce and apply a molecule of a desirable structure for a given purpose. In the light of its ability to bridge chemical structure with a function, MET-EFFECT proposes brand new concept of novel multifunctional rhenium and iridium flavonoid complexes aimed to serve as metallodrugs and homogenous catalysts. The fusion of academic knowledge and industry-oriented perspective establishes a fruitful collaboration of an international and intersectoral profile. Well-recognized members of Consortium gains beyond the-state-of-the-art advances in bioinorganic chemistry by: a) developing novel Re and Ir complexes containing apigenin-like ligands, a natural bioactive flavone-type of molecules; b) determining the antitumor potential of newly synthesized Re(V) and Ir(III) complexes on a panel of various human cancer cell lines; c) evaluating the applicative potential of novel Re(V) complexes as homogeneous catalysts in OAT-inspired reactions (olefin epoxidation, oxoanions catalytic reduction and water oxidation). The structure and sentence of 7 work packages implemented through 37 secondments will enable the promotion of newly synthesized metal-based compounds in industrial environment for the sake of reaching their final applications. The widespread partnership creates an outstanding, R&I oriented ambient ensuring free knowledge sharing and career upgrade of the participating staff. By developing functional metal-based molecules, MET-EFFECT encompasses full human intellectual capacity capable to challenge technical, economic and environmental demands of wider society for applied but sustainable chemistry.
Champ scientifique
Mots‑clés
Programme(s)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Régime de financement
HORIZON-TMA-MSCA-SE - HORIZON TMA MSCA Staff ExchangesCoordinateur
11000 Belgrade
Serbie
L’entreprise s’est définie comme une PME (petite et moyenne entreprise) au moment de la signature de la convention de subvention.