Descrizione del progetto
Valutazione dell’efficienza citotossica e catalitica di nuovi complessi metallici
Il progetto MET-EFFECT, finanziato dal programma MSCA, prevede di sviluppare nuovi complessi multifunzionali di renio (Re) e iridio (Ir) per lo sviluppo di metallofarmaci. I ricercatori progetteranno complessi di renio e iridio contenenti legami simili all’apigenina, una molecola bioattiva naturale di tipo flavonico. Il potenziale antitumorale dei complessi sarà testato su un panel di varie linee cellulari tumorali umane. I ricercatori valuteranno inoltre la possibilità di utilizzare i complessi di Re(V) appena sintetizzati come catalizzatori omogenei nell’epossidazione delle olefine, nella riduzione catalitica degli ossianioni e nelle reazioni di ossidazione dell’acqua.
Obiettivo
The immense power of practice-oriented synthetic chemistry is demonstrated through the opportunity to design, synthesize, optimize, produce and apply a molecule of a desirable structure for a given purpose. In the light of its ability to bridge chemical structure with a function, MET-EFFECT proposes brand new concept of novel multifunctional rhenium and iridium flavonoid complexes aimed to serve as metallodrugs and homogenous catalysts. The fusion of academic knowledge and industry-oriented perspective establishes a fruitful collaboration of an international and intersectoral profile. Well-recognized members of Consortium gains beyond the-state-of-the-art advances in bioinorganic chemistry by: a) developing novel Re and Ir complexes containing apigenin-like ligands, a natural bioactive flavone-type of molecules; b) determining the antitumor potential of newly synthesized Re(V) and Ir(III) complexes on a panel of various human cancer cell lines; c) evaluating the applicative potential of novel Re(V) complexes as homogeneous catalysts in OAT-inspired reactions (olefin epoxidation, oxoanions catalytic reduction and water oxidation). The structure and sentence of 7 work packages implemented through 37 secondments will enable the promotion of newly synthesized metal-based compounds in industrial environment for the sake of reaching their final applications. The widespread partnership creates an outstanding, R&I oriented ambient ensuring free knowledge sharing and career upgrade of the participating staff. By developing functional metal-based molecules, MET-EFFECT encompasses full human intellectual capacity capable to challenge technical, economic and environmental demands of wider society for applied but sustainable chemistry.
Campo scientifico
Parole chiave
Programma(i)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Meccanismo di finanziamento
HORIZON-TMA-MSCA-SE - HORIZON TMA MSCA Staff ExchangesCoordinatore
11000 Belgrade
Serbia
L’organizzazione si è definita una PMI (piccola e media impresa) al momento della firma dell’accordo di sovvenzione.