Descripción del proyecto
Nuevos complejos metálicos evaluados por su eficacia citotóxica y catalítica
El objetivo del proyecto MET-EFFECT, financiado por las Acciones Marie Skłodowska-Curie, es desarrollar nuevos complejos multifuncionales de renio (Re) e iridio (Ir) para el diseño de metalofármacos. Los investigadores diseñarán complejos de Re e Ir que contengan ligandos similares a la apigenina, un tipo de molécula bioactiva natural de tipo flavona. El potencial antineoplásico de los complejos se probará en un grupo de varias líneas celulares de cáncer humano. Además, los investigadores evaluarán la capacidad de los complejos Re(V) recién sintetizados para utilizarse como catalizadores homogéneos en reacciones de epoxidación de olefinas, reducción catalítica de oxoaniones y de oxidación del agua.
Objetivo
The immense power of practice-oriented synthetic chemistry is demonstrated through the opportunity to design, synthesize, optimize, produce and apply a molecule of a desirable structure for a given purpose. In the light of its ability to bridge chemical structure with a function, MET-EFFECT proposes brand new concept of novel multifunctional rhenium and iridium flavonoid complexes aimed to serve as metallodrugs and homogenous catalysts. The fusion of academic knowledge and industry-oriented perspective establishes a fruitful collaboration of an international and intersectoral profile. Well-recognized members of Consortium gains beyond the-state-of-the-art advances in bioinorganic chemistry by: a) developing novel Re and Ir complexes containing apigenin-like ligands, a natural bioactive flavone-type of molecules; b) determining the antitumor potential of newly synthesized Re(V) and Ir(III) complexes on a panel of various human cancer cell lines; c) evaluating the applicative potential of novel Re(V) complexes as homogeneous catalysts in OAT-inspired reactions (olefin epoxidation, oxoanions catalytic reduction and water oxidation). The structure and sentence of 7 work packages implemented through 37 secondments will enable the promotion of newly synthesized metal-based compounds in industrial environment for the sake of reaching their final applications. The widespread partnership creates an outstanding, R&I oriented ambient ensuring free knowledge sharing and career upgrade of the participating staff. By developing functional metal-based molecules, MET-EFFECT encompasses full human intellectual capacity capable to challenge technical, economic and environmental demands of wider society for applied but sustainable chemistry.
Ámbito científico
Palabras clave
Programa(s)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Régimen de financiación
HORIZON-TMA-MSCA-SE - HORIZON TMA MSCA Staff ExchangesCoordinador
11000 Belgrade
Serbia
Organización definida por ella misma como pequeña y mediana empresa (pyme) en el momento de la firma del acuerdo de subvención.