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Comprehensive and personalized assessment of acute coronary syndrome by multiomic approach and artificial intelligence strategy

Project description

DEENESFRITPL

Multiomics approach for acute coronary syndrome diagnosis

Acute coronary syndrome (ACS) is a medical emergency that can develop into major adverse cardiovascular events (MACE). The EU-funded CardioSCOPE project will bring together experts from academia and companies to exchange and expand expertise on interdisciplinary approaches in cardiovascular diseases through a comprehensive multiomics approach. The project targets the discovery of novel pathological players to provide further knowledge into ACS development and progression toward MACE. CardioSCOPE will use well-defined prospective cohorts to discover and validate novel genomic, transcriptomic, proteomic, and metabolomic signatures and use an ML and AI strategy to deliver more accurate diagnosis and prediction. The project will also train scientists competent for the upcoming ‘omics’ era.

Objective

The CardioSCOPE proposal aims to bring together experts from Companies and Αcademia throughout Europe to exchange and expand their expertise on interdisciplinary approaches, to enhance the Research and Innovation capacity of Europe in the field of cardiovascular diseases. Connecting and expanding Europe-wide biobanks and expertise through a comprehensive multiomics approach for the discovery of novel pathological players, CardioSCOPE will give deeper insights into acute coronary syndrome (ACS) development and progression towards major adverse cardiovascular events (MACE). We will use well-defined prospective cohorts to discover and validate novel genomic, transcriptomic, proteomic and metabolomic signatures specific for ACS and MACE, to be combined in multimarker models by machine learning/artificial intelligence algorithms, enabling more accurate ACS diagnosis and MACE prediction. This excellent research network aims at building scientists competent for the upcoming “omics” era by training and knowledge transfer. Specific research skills not available at home institutions will be acquired through individually designed secondment plans, training schools, webinars and short-term courses. Intersectoral activities will improve entrepreneurial skills of consortium staff and facilitate transformation of scientific breakthroughs into commercially available products/services. CardioSCOPE includes experts with a wide clinical and research experience, access to patients with ACS and the expertise required for achieving set goals. World-class institutions gathered within this consortium (from 6 countries: 7 academic, 4 companies, 1 hospital) offer specific expertise, state-of-the-art equipment and adequate human resources to address these challenges. In summary, the results of this project will transcend our own scientific interests to enable a transfer of knowledge into a multidisciplinary environment and achieving significant impact on ACS management and policies in Europe.

Fields of science

Programme(s)

Topic(s)

Call for proposal

HORIZON-MSCA-2021-SE-01

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Funding Scheme

HORIZON-AG-UN - HORIZON Unit Grant

Coordinator

UNIVERSITA DEGLI STUDI DI MILANO
Net EU contribution
€ 156 400,00
Address
Via festa del perdono 7
20122 Milano
Italy

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Region
Nord-Ovest Lombardia Milano
Activity type
Higher or Secondary Education Establishments
Links
Other funding
€ 0,00

Participants (10)

Partners (1)

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EC signature date 13 October 2022
Last update: 17 October 2022

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Permalink: https://cordis.europa.eu/project/id/101086397

European Union, 2023