Descrizione del progetto
Approccio multiomico per la diagnosi della sindrome coronarica acuta
La sindrome coronarica acuta (SCA) è un’emergenza medica che può evolvere in eventi cardiovascolari avversi maggiori (MACE). Il progetto CardioSCOPE, finanziato dall’UE, riunirà esperti del mondo accademico e delle aziende per scambiarsi le reciproche competenze sugli approcci interdisciplinari alle malattie cardiovascolari e ampliarle, attraverso un percorso multiomico completo. Il progetto si propone di scoprire nuovi agenti patologici per fornire ulteriori conoscenze sullo sviluppo della sindrome e sulla progressione verso eventi MACE. CardioSCOPE utilizzerà coorti prospettiche ben definite per scoprire e convalidare nuove firme genomiche, trascrittomiche, proteomiche e metabolomiche e utilizzerà una strategia di apprendimento automatizzato e intelligenza artificiale per fornire diagnosi e previsioni più accurate. Il progetto formerà anche scienziati competenti per l’imminente era «omica».
Obiettivo
The CardioSCOPE proposal aims to bring together experts from Companies and Αcademia throughout Europe to exchange and expand their expertise on interdisciplinary approaches, to enhance the Research and Innovation capacity of Europe in the field of cardiovascular diseases. Connecting and expanding Europe-wide biobanks and expertise through a comprehensive multiomics approach for the discovery of novel pathological players, CardioSCOPE will give deeper insights into acute coronary syndrome (ACS) development and progression towards major adverse cardiovascular events (MACE). We will use well-defined prospective cohorts to discover and validate novel genomic, transcriptomic, proteomic and metabolomic signatures specific for ACS and MACE, to be combined in multimarker models by machine learning/artificial intelligence algorithms, enabling more accurate ACS diagnosis and MACE prediction. This excellent research network aims at building scientists competent for the upcoming “omics” era by training and knowledge transfer. Specific research skills not available at home institutions will be acquired through individually designed secondment plans, training schools, webinars and short-term courses. Intersectoral activities will improve entrepreneurial skills of consortium staff and facilitate transformation of scientific breakthroughs into commercially available products/services. CardioSCOPE includes experts with a wide clinical and research experience, access to patients with ACS and the expertise required for achieving set goals. World-class institutions gathered within this consortium (from 6 countries: 7 academic, 4 companies, 1 hospital) offer specific expertise, state-of-the-art equipment and adequate human resources to address these challenges. In summary, the results of this project will transcend our own scientific interests to enable a transfer of knowledge into a multidisciplinary environment and achieving significant impact on ACS management and policies in Europe.
Campo scientifico
Parole chiave
Programma(i)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Meccanismo di finanziamento
HORIZON-TMA-MSCA-SE - HORIZON TMA MSCA Staff ExchangesCoordinatore
20122 Milano
Italia