Description du projet
Une approche «multi-omique» pour le diagnostic du syndrome coronarien aigu
Les syndromes coronariens aigus (SCA) sont des urgences médicales susceptibles d’évoluer vers des épisodes cardio-vasculaires adverses majeurs (ECAM). Le projet CardioSCOPE, financé par l’UE, rassemblera des experts du monde universitaire et des entreprises dans l’objectif d’échanger et d’étendre le savoir-faire relatif aux approches interdisciplinaires des maladies cardiovasculaires par le biais d’une approche «multi-omique» complète. Le projet a pour ambition de découvrir de nouveaux facteurs pathologiques afin d’approfondir les connaissances concernant le développement du SCA et sa progression vers l’ECAM. CardioSCOPE aura recours à des cohortes prospectives bien définies pour découvrir et valider de nouvelles signatures génomiques, transcriptomiques, protéomiques et métabolomiques, avant d’adopter une stratégie reposant sur l’apprentissage automatique et l’intelligence artificielle pour améliorer la précision des diagnostics et des prédictions. Le projet permettra également de former des scientifiques compétents pour l’ère «omique» qui s’annonce.
Objectif
The CardioSCOPE proposal aims to bring together experts from Companies and Αcademia throughout Europe to exchange and expand their expertise on interdisciplinary approaches, to enhance the Research and Innovation capacity of Europe in the field of cardiovascular diseases. Connecting and expanding Europe-wide biobanks and expertise through a comprehensive multiomics approach for the discovery of novel pathological players, CardioSCOPE will give deeper insights into acute coronary syndrome (ACS) development and progression towards major adverse cardiovascular events (MACE). We will use well-defined prospective cohorts to discover and validate novel genomic, transcriptomic, proteomic and metabolomic signatures specific for ACS and MACE, to be combined in multimarker models by machine learning/artificial intelligence algorithms, enabling more accurate ACS diagnosis and MACE prediction. This excellent research network aims at building scientists competent for the upcoming “omics” era by training and knowledge transfer. Specific research skills not available at home institutions will be acquired through individually designed secondment plans, training schools, webinars and short-term courses. Intersectoral activities will improve entrepreneurial skills of consortium staff and facilitate transformation of scientific breakthroughs into commercially available products/services. CardioSCOPE includes experts with a wide clinical and research experience, access to patients with ACS and the expertise required for achieving set goals. World-class institutions gathered within this consortium (from 6 countries: 7 academic, 4 companies, 1 hospital) offer specific expertise, state-of-the-art equipment and adequate human resources to address these challenges. In summary, the results of this project will transcend our own scientific interests to enable a transfer of knowledge into a multidisciplinary environment and achieving significant impact on ACS management and policies in Europe.
Champ scientifique
Programme(s)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Régime de financement
HORIZON-TMA-MSCA-SE - HORIZON TMA MSCA Staff ExchangesCoordinateur
20122 Milano
Italie