Descripción del proyecto
Técnica multiómica para el diagnóstico del síndrome coronario agudo
El síndrome coronario agudo (SCA) es una emergencia médica que puede derivar en eventos cardiovasculares adversos mayores (MACE, por sus siglas en inglés). El proyecto CardioSCOPE, financiado con fondos europeos, reunirá a expertos del mundo académico y empresarial para intercambiar y ampliar conocimientos sobre enfoques interdisciplinarios de las enfermedades cardiovasculares mediante un planteamiento multiómico integral. El objetivo del proyecto es descubrir nuevos agentes patológicos que aporten más conocimientos sobre el desarrollo del SCA y la progresión hacia los MACE. El equipo de CardioSCOPE utilizará cohortes prospectivas bien definidas para descubrir y validar nuevas firmas genómicas, transcriptómicas, proteómicas y metabolómicas y utilizará una estrategia de aprendizaje automático e inteligencia artificial para ofrecer un diagnóstico y una predicción más precisos. En el proyecto también se formará a científicos competentes para la próxima era «ómica».
Objetivo
The CardioSCOPE proposal aims to bring together experts from Companies and Αcademia throughout Europe to exchange and expand their expertise on interdisciplinary approaches, to enhance the Research and Innovation capacity of Europe in the field of cardiovascular diseases. Connecting and expanding Europe-wide biobanks and expertise through a comprehensive multiomics approach for the discovery of novel pathological players, CardioSCOPE will give deeper insights into acute coronary syndrome (ACS) development and progression towards major adverse cardiovascular events (MACE). We will use well-defined prospective cohorts to discover and validate novel genomic, transcriptomic, proteomic and metabolomic signatures specific for ACS and MACE, to be combined in multimarker models by machine learning/artificial intelligence algorithms, enabling more accurate ACS diagnosis and MACE prediction. This excellent research network aims at building scientists competent for the upcoming “omics” era by training and knowledge transfer. Specific research skills not available at home institutions will be acquired through individually designed secondment plans, training schools, webinars and short-term courses. Intersectoral activities will improve entrepreneurial skills of consortium staff and facilitate transformation of scientific breakthroughs into commercially available products/services. CardioSCOPE includes experts with a wide clinical and research experience, access to patients with ACS and the expertise required for achieving set goals. World-class institutions gathered within this consortium (from 6 countries: 7 academic, 4 companies, 1 hospital) offer specific expertise, state-of-the-art equipment and adequate human resources to address these challenges. In summary, the results of this project will transcend our own scientific interests to enable a transfer of knowledge into a multidisciplinary environment and achieving significant impact on ACS management and policies in Europe.
Ámbito científico
Palabras clave
Programa(s)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Régimen de financiación
HORIZON-TMA-MSCA-SE - HORIZON TMA MSCA Staff ExchangesCoordinador
20122 Milano
Italia