Comprehensive and personalized assessment of acute coronary syndrome by multiomic approach and artificial intelligence strategy

Project Information

CardioSCOPE

Grant agreement ID: 101086397

DOI

10.3030/101086397

EC signature date 13 October 2022

Start date 1 January 2023

End date 31 December 2026

Funded under

• Marie Skłodowska-Curie Actions (MSCA)

Total cost

No data

EU contribution

€ 1 518 000,00

Coordinated by

UNIVERSITA DEGLI STUDI DI MILANO
Italy

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Websites, patent fillings, videos etc. (1)

Plan for dissemination and exloitation including communication activities

Other (4)

SOP for analytical phase

set of optimized protocols related to the analytical phase

Study protocol

Set of optimized protocols related to patient recruitment and sample collection

SOP for ML/AI and bioinformatics

set of optimized protocols related to data integration and bioinformatics

SOP for pre-analytical phase

set of optimized protocols related to the preanalytical phase

Data Management Plan (1)

Data management plan

a report outlining the strategies and ethical requirements for collecting storing processing and sharing data generated during the project

Publications

Peer reviewed articles (22)

Editorial: Multiomic approaches in atherosclerosis

Author(s): Sopić, Miron; Mitić, Tijana; Sluimer, Judith; Magni, Paolo; Devaux, Yvan
Published in: Vascular Pharmacology, 2025
Publisher: ELSEVIER
DOI: 10.1016/J.VPH.2025.107501

Risk Factors and Immunoinflammatory Mechanisms Leading to Atherosclerosis: Focus on the Role of Oral Microbiota Dysbiosis

Author(s): Riccardo Mattia Ricciardi; Alessia Cipollone; Damiano D’Ardes; Davide Di Giacomo; Pamela Pignatelli; Francesco Cipollone; Maria Cristina Curia; Paolo Magni; Marco Bucci
Published in: Microorganisms, 2023, ISSN 2076-2607
Publisher: MDPI
DOI: 10.3390/MICROORGANISMS11061479

Costus afer Ker Gawl (Bush cane) extracts modulate glucose uptake, triglyceride accumulation and oxidative stress in human SW 872 liposarcoma and HepG2 hepatocarcinoma cells

Author(s): Achille Parfait NWAKIBAN ATCHAN; Jules-Roger KUIATE; Gabriel AGBOR AGBOR; François Ferriere; Mario Dell’Agli; Paolo Magni; Armelle Deutou Tchamgoue
Published in: Crossref, 2025
Publisher: RESEARCH SQUARE
DOI: 10.21203/RS.3.RS-5690853/V1

An integrated view of the pathophysiological crosstalk between adipose tissue, bone and cardiovascular system in men and women

Author(s): Fationa Tolaj Klinaku; Laura Comi; Claudia Giglione; Paolo Magni
Published in: Journal of Endocrinological Investigation, 2024, ISSN 1720-8386
Publisher: Springer
DOI: 10.1007/S40618-024-02516-X

Toward Precision Medicine in Atherosclerotic Cardiovascular Disease: Insights from Omics Data into Sex Differences

Author(s): Munjas, Jelena; Vladimirov, Sandra; Ratković, Tamara; Comi, Laura; Giglione, Claudia; Tanasković, Ilija; Gojković, Tamara; Rakić, Branka; Davidović, Aleksandar; Vukmirović, Luka; Milanov, Marko; Cvijanović, Dane; Magni, Paolo; Sopić, Miron
Published in: Current Atherosclerosis Reports, 2025
Publisher: SPRINGER NATURE
DOI: 10.1007/S11883-025-01380-1

Multiomics tools for improved atherosclerotic cardiovascular disease management

Author(s): Sopić, Miron; Vilne, Baiba; Gerdts, Eva; Trindade, Fábio; Uchida, Shizuka; Khatib, Soliman; Wettinger, Stephanie Bezzina; Devaux, Yvan; Magni, Paolo
Published in: Trends in Molecular Medicine, 2023, ISSN 1471-4914
Publisher: Elsevier BV
DOI: 10.1016/J.MOLMED.2023.09.004

LncRNAs as Regulators of Atherosclerotic Plaque Stability

Author(s): Aleksa Petkovic; Sanja Erceg; Jelena Munjas; Ana Ninic; Sandra Vladimirov; Aleksandar Davidovic; Luka Vukmirovic; Marko Milanov; Dane Cvijanovic; Tijana Mitic; Miron Sopic
Published in: Cells, 2023, ISSN 2073-4409
Publisher: MDPI
DOI: 10.3390/cells12141832

Current status and challenges of multi-omics research using animal models of atherosclerosis

Author(s): Tijana Mitić; Adriana Georgescu; Nicoleta Alexandru-Moise; Michael J. Davies; Cecile Vindis; Susana Novella; Eva Gerdts; Georgios Kararigas; Stephanie Bezzina Wettinger; Melissa M. Formosa; Brenda R. Kwak; Filippo Molica; Nuria Amigo; Andrea Caporali; Fernando de la Cuesta; Ignacio Fernando Hall; Angeliki Chroni; Fabio Martelli; Johannes A. Schmid; Paolo Magni; Dimitris Kardassis
Published in: Journal of Molecular and Cellular Cardiology Plus, 2025
Publisher: ELSEVIER
DOI: 10.1016/J.JMCCPL.2025.100476

Navigating the path of reproducibility in microRNA-based biomarker research with ring trials

Author(s): Sopić, Miron; Devaux, Yvan; de Gonzalo-Calvo, David
Published in: Clinical Chemistry and Laboratory Medicine (CCLM), 2024
Publisher: DE GRUYTER BRILL
DOI: 10.1515/CCLM-2024-0531

Additional file 1 of Web discussions on cardiovascular diseases: pre-COVID-19 evaluation and impact of the COVID-19 pandemic – Web listening analysis in the Italian population

Author(s): Cecchini, Isabella; Biroli, Matteo; Massaroni, Katia; Folco, Emanuela; Montebelli, Maria Rita; Ciancamerla, Giuseppe; Giudice, Daniela; Pedretti, Roberto Franco Enrico; Magni, Paolo
Published in: 2024
Publisher: FIGSHARE
DOI: 10.6084/M9.FIGSHARE.27928424.V1

Insulin-like Growth Factor 1, Growth Hormone, and Anti-Müllerian Hormone Receptors Are Differentially Expressed during GnRH Neuron Development

Author(s): Alyssa J. J. Paganoni; Rossella Cannarella; Roberto Oleari; Federica Amoruso; Renata Antal; Marco Ruzza; Chiara Olivieri; Rosita A. Condorelli; Sandro La Vignera; Fationa Tolaj; Anna Cariboni; Aldo E. Calogero; Paolo Magni
Published in: International Journal of Molecular Sciences; Volume 24; Issue 17; Pages: 13073, 2023, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/IJMS241713073

Multiomics in atherosclerotic cardiovascular disease

Author(s): Nordestgaard, Liv Tybjærg; Wolford, Brooke N.; de Gonzalo-Calvo, David; Sopić, Miron; Devaux, Yvan; Matic, Ljubica; Wettinger, Stephanie Bezzina; Schmid, Johannes A.; Amigó, Núria; Masana, Lluís; Catapano, Alberico L.; Kardassis, Dimitris; Magni, Paolo
Published in: Atherosclerosis, 2025
Publisher: ELSEVIER
DOI: 10.1016/J.ATHEROSCLEROSIS.2025.120414

Nutraceutical alternatives to red yeast rice extract/monacolin K for moderate hypercholesterolaemia: Current evidence and knowledge gaps: Nutraceuticals and hypercholesterolaemia

Author(s): Comi, Laura; Giglione, Claudia; Tolaj, Fationa; Parolini, Cinzia; Olivieri, Chiara; Ruzza, Marco; Tollemeto, Valentina; Zurlo, Maria; Pialorsi, Federico; Seneci, Antonio; Magni, Paolo
Published in: European Atherosclerosis Journal, 2023
Publisher: European Atherosclerosis Journal
DOI: 10.56095/EAJ.V1I3.20

Single-cell RNA sequencing (scRNA-seq) and its insights into cellular heterogeneity in atherosclerosis

Author(s): Yu, Baixue; Sopić, Miron; Sluimer, Judith C.
Published in: Vascular Pharmacology, 2025
Publisher: ELSEVIER
DOI: 10.1016/J.VPH.2025.107499

Adherence to Mediterranean Diet: A Population-Based Longitudinal Cohort Study

Author(s): Elisa Mattavelli; Elena Olmastroni; Manuela Casula; Liliana Grigore; Fabio Pellegatta; Andrea Baragetti; Paolo Magni; Alberico L. Catapano
Published in: Nutrients; Volume 15; Issue 8; Pages: 1844, 2023, ISSN 2072-6643
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/NU15081844

Evaluation of Metabolic Dysfunction-Associated Fatty Liver Disease-Related Pathogenic Mechanisms in Human Steatotic Liver Cell-Based Model: Beneficial Effects of Prunus domestica L. subsp. syriaca Extract

Author(s): Laura Comi; Claudia Giglione; Fationa Tolaj Klinaku; Lorenzo Da Dalt; Hammad Ullah; Maria Daglia; Paolo Magni
Published in: Nutrients, 2025
Publisher: MDPI
DOI: 10.3390/NU17071249

British Journal of Pharmacology

Author(s): Miron Sopić; Sandra Vladimirov; Jelena Munjas; Tijana Mitić; Ignacio Fernando Hall; Amela Jusic; Dusan Ruzic; Yvan Devaux
Published in: British Journal of Pharmacology, 2024, ISSN 0007-1188
Publisher: British Pharmacological Society
DOI: 10.1111/BPH.16412

Valorizing Agro‐Food Waste for Nutraceutical Development: Sustainable Approaches for Managing Metabolic Dysfunction‐Associated Steatotic Liver Disease and Related Co‐Morbidities

Author(s): Comi, Laura; Giglione, Claudia; Klinaku, Fationa Tolaj; Pialorsi, Federico; Tollemeto, Valentina; Zurlo, Maria; Seneci, Antonio; Magni, Paolo
Published in: Food Frontiers, 2024
Publisher: WILEY
DOI: 10.1002/FFT2.535

Integration of epigenetic regulatory mechanisms in heart failure

Author(s): Sopić, Miron; Robinson, Emma L.; Emanueli, Costanza; Srivastava, Prashant; Angione, Claudio; Gaetano, Carlo; Condorelli, Gianluigi; Martelli, Fabio; Pedrazzini, Thierry; Devaux, Yvan
Published in: Basic Research in Cardiology, 2023, ISSN 0300-8428
Publisher: Springer Science and Business Media Deutschland GmbH
DOI: 10.1007/S00395-023-00986-3

The converging roles of microRNAs and lipid metabolism in atherosclerotic cardiovascular disease and cancer

Author(s): Vladimirov, Sandra; Tomašević, Marija; Popov, Nemanja; Munjas, Jelena; de Gonzalo-Calvo, David; Sopić, Miron
Published in: Seminars in Cancer Biology, 2025
Publisher: ELSEVIER
DOI: 10.1016/J.SEMCANCER.2025.06.005

BMC Public Health

Author(s): Cecchini I.; Biroli M.; Massaroni K.; Folco E.; Montebelli M. R.; Ciancamerla G.; Giudice D.; Pedretti R. F. E.; Magni P.
Published in: BMC Public Health, 2024, ISSN 1471-2458
Publisher: BMC
DOI: 10.1186/S12889-024-20615-5

Transcriptomic research in atherosclerosis: Unravelling plaque phenotype and overcoming methodological challenges

Author(s): Sopić, Miron; Karaduzovic-Hadziabdic, Kanita; Kardassis, Dimitris; Maegdefessel, Lars; Martelli, Fabio; Meerson, Ari; Munjas, Jelena ; Niculescu, Loredan S.; Stoll, Monika; Magni, Paolo; Devaux, Yvan;
Published in: Journal of Molecular and Cellular Cardiology Plus, 2023, ISSN 2772-9761
Publisher: ELSEVIER
DOI: 10.1016/J.JMCCPL.2023.100048