Connected Hubs in Ageing: Healthy Living to Protect Cerebrovascular Function

Informations projet

CHAngeing

N° de convention de subvention: 101087071

DOI 10.3030/101087071

Date de signature de la CE 10 Novembre 2022

Date de début 1 Janvier 2023

Date de fin 31 Decembre 2026

Financé au titre de

• Widening participation and spreading excellence

Coût total € 4 999 693,75

Contribution de l’UE € 4 999 693,75

Coordonné par

UNIVERSIDADE DE COIMBRA
Portugal

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, rapports (4)

Conceptual design and pre-planning for pilot and demonstrator report

This report will reflect the work done by the multidisciplinary focus groups with experts and end-users to to co-create a new ICT instrumentalized toolkit for lifestyle assessment to prevent CVD based on Mediterranean diet culture; and to implement the preparatory steps, and institutional framework, for a demonstrator to highlight good practices and health outcomes from ICT-supported rehabilitation strategies of stroke survivors. The report will also address the proposed roadmap to identify and characterize the population cohorts to be involved in the appropriate pilots and demonstrators (territory mapping exercise contemplating urban and rural settings, located in Center Region of Portugal and in Crete).

CHAngeing educational portfolio

An innovative educational program will be developed, resulting from collaborative initiatives and synergies synergies between PhD programs in health and ageing-related topics based at the UoC/FORTH and UC, to train master’s and PhD students. The educational portfolio will reflect the high alignment with the scientific scope of the proposal on ageing and healthy lifestyles, with strong educational elements of innovation and entrepreneurship will be implemented.

Report on barriers, enablers and opportunities to adoption of ICT’s to support healthy lifestyles and CVD patients rehabilitation

This report will gather a systematic review regarding the barriers, enablers and opportunities for the use of ICT’s, such as digital health technologies reimbursement restrictions, that impair large-scale adoption or the ‘willingness-to-pay’ gap.

Communication, dissemination and exploitation plan

To deliver a communication, dissemination and exploitation plan based on Open Science practices to boost CHAngeing excellence hubs national and international visibility, containing details concerning communication and dissemination activities targeting: 1) high-impact scientific publications and attraction of new talents to both hubs; 2) citizens; 3) private funding, funding agencies, policymakers and other relevant stakeholders.

Plan de gestion des données (1)

Data Management Plan

The first project deliverable will be a Data Management Plan (DMP) aligned with the article 17 of the Annotated Grant Agreement and using the template provided by the European Commission, where it will be detailed the type of data generated and all the required information on how data lifecycle will be handled. This DMP will be a living document throughout project implementation, updated and enriched every time necessary and if possible, will be registered as a non-restricted public deliverable to assure DMP publication. CHAngeing will produce research, personal and technical data which will be managed accordingly to the FAIR principle and following Horizon Europe guidelines.

Publications

Articles approuvés par les pairs (8)

Adipose tissue-liver cross-talk: a route to hepatic dysfunction in pregnant women with obesity

Auteurs: Diana Sousa, Carina C. Magalhães, Paulo Matafome, Susana P. Pereira
Publié dans: Bioscience Reports, Numéro 44, 2024, ISSN 0144-8463
Éditeur: Portland Press Ltd.
DOI: 10.1042/BSR20231679

Ageing in Place: Older People Identify Barriers to Remaining in Low-Density Areas

Auteurs: Paulo Nossa; Sofia Vale Pereira; Margarida Lima; Cristina C. Vieira; Anabela Mota-Pinto
Publié dans: Journal of Population Ageing, 2024, ISSN 1874-7876
Éditeur: Springer
DOI: 10.1007/s12062-024-09449-6

Cellular reprogramming as a tool to model human aging in a dish

Auteurs: Patrícia Pitrez, Luís M. Monteiro, Oliver Borgogno, Xavier Nissan, Jerome Mertens and Lino Ferreira
Publié dans: Nature Communications, Numéro doi.org/10.1038/s41467-024-46004-5, 2024, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/s41467-024-46004-5

The senotherapeutic potential of phytochemicals for age-related intestinal disease

Auteurs: Costa CM, Pedrosa SS, Kirkland JL, Reis F, Madureira AR
Publié dans: Ageing Res Rev, Numéro 104:102619, 2024, ISSN 1872-9649
Éditeur: Elsevier
DOI: 10.1016/j.arr.2024.102619.

Glutamate-specific gene linked to human brain evolution enhances synaptic plasticity and cognitive processes

Auteurs: Cleanthe Spanaki; Kyriaki Sidiropoulou; Zoe Petraki; Konstantinos Diskos; Xanthippi Konstantoudaki; Emmanouela Volitaki; Konstantina Mylonaki; Maria Savvaki; Andreas Plaitakis
Publié dans: iScience, 2024, ISSN 2589-0042
Éditeur: Elsevier
DOI: 10.1016/j.isci.2024.108821

Local coordination of mRNA storage and degradation near mitochondria modulates C. elegans ageing

Auteurs: Ioanna Daskalaki, Maria Markaki, Ilias Gkikas and Nektarios Tavernarakis
Publié dans: EMBO Journal, Numéro doi: 10.15252/embj.2022112446, 2023, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.15252/embj.2022112446

Neurovascular dysfunction in psychiatric disorders: Underlying mechanisms and therapeutic approaches

Auteurs: Eliane Swely Sanches, Daniela Simões, Filipa Isabel Baptista, Ana Paula Silva
Publié dans: European Journal of Clinical Investigation, Numéro 55, 2024, ISSN 0014-2972
Éditeur: Wiley
DOI: 10.1111/eci.14319

Spermidine is essential for fasting-mediated autophagy and longevity

Auteurs: Sebastian J. Hofer; Ioanna Daskalaki; Martina Bergmann; Jasna Friščić; Andreas Zimmermann; Melanie I. Mueller; Mahmoud Abdellatif; Raffaele Nicastro; Sarah Masser; Sylvère Durand; Alexander Nartey; Mara Waltenstorfer; Sarah Enzenhofer; Isabella Faimann; Verena Gschiel; Thomas Bajaj; Christine Niemeyer; Ilias Gkikas; Lukas Pein; Giulia Cerrato; Hui Pan; YongTian Liang; Jelena Tadic; Andrea Jerkovic; Fanny Aprahamian; Christine E. Robbins; Nitharsshini Nirmalathasan; Hansjörg Habisch; Elisabeth Annerer; Frederik Dethloff; Michael Stumpe; Franziska Grundler; Françoise Wilhelmi de Toledo; Daniel E. Heinz; Daniela A. Koppold; Anika Rajput Khokhar; Andreas Michalsen; Norbert J. Tripolt; Harald Sourij; Thomas R. Pieber; Rafael de Cabo; Mark A. McCormick; Christoph Magnes; Oliver Kepp; Joern Dengjel; Stephan J. Sigrist; Nils C. Gassen; Simon Sedej; Tobias Madl; Claudio De Virgilio; Ulrich Stelzl; Markus H. Hoffmann; Tobias Eisenberg; Nektarios Tavernarakis; Guido Kroemer; Frank Madeo
Publié dans: Nature Cell Biology, 2024, ISSN 1476-4679
Éditeur: Nature Publishing Group
DOI: 10.1038/s41556-024-01468-x

Thèses (2)

Pharmacological Strategies to Target Cellular Senescence

Auteurs: Inês Tomé Ribeiro
Publié dans: PhD thesis, 2024
Éditeur: University of Coimbra

Avaliação de estilos de vida saudáveis inspirados pela cultura da dieta mediterrânica - recurso a inovação tecnológica

Auteurs: Thomaz Peixoto Rossini
Publié dans: Master thesis, 2024
Éditeur: University of Coimbra