Connected Hubs in Ageing: Healthy Living to Protect Cerebrovascular Function

Informations projet

CHAngeing

N° de convention de subvention: 101087071

DOI

10.3030/101087071

Date de signature de la CE 10 Novembre 2022

Date de début 1 Janvier 2023

Date de fin 31 Decembre 2026

Financé au titre de

• Widening participation and spreading excellence

Coût total

€ 4 999 693,75

Contribution de l’UE

€ 4 999 693,75

Coordonné par

UNIVERSIDADE DE COIMBRA
Portugal

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (4)

Conceptual design and pre-planning for pilot and demonstrator report

This report will reflect the work done by the multidisciplinary focus groups with experts and end-users to to co-create a new ICT instrumentalized toolkit for lifestyle assessment to prevent CVD based on Mediterranean diet culture; and to implement the preparatory steps, and institutional framework, for a demonstrator to highlight good practices and health outcomes from ICT-supported rehabilitation strategies of stroke survivors. The report will also address the proposed roadmap to identify and characterize the population cohorts to be involved in the appropriate pilots and demonstrators (territory mapping exercise contemplating urban and rural settings, located in Center Region of Portugal and in Crete).

CHAngeing educational portfolio

An innovative educational program will be developed, resulting from collaborative initiatives and synergies synergies between PhD programs in health and ageing-related topics based at the UoC/FORTH and UC, to train master’s and PhD students. The educational portfolio will reflect the high alignment with the scientific scope of the proposal on ageing and healthy lifestyles, with strong educational elements of innovation and entrepreneurship will be implemented.

Report on barriers, enablers and opportunities to adoption of ICT’s to support healthy lifestyles and CVD patients rehabilitation

This report will gather a systematic review regarding the barriers, enablers and opportunities for the use of ICT’s, such as digital health technologies reimbursement restrictions, that impair large-scale adoption or the ‘willingness-to-pay’ gap.

Communication, dissemination and exploitation plan

To deliver a communication, dissemination and exploitation plan based on Open Science practices to boost CHAngeing excellence hubs national and international visibility, containing details concerning communication and dissemination activities targeting: 1) high-impact scientific publications and attraction of new talents to both hubs; 2) citizens; 3) private funding, funding agencies, policymakers and other relevant stakeholders.

Data Management Plan (1)

Data Management Plan

The first project deliverable will be a Data Management Plan (DMP) aligned with the article 17 of the Annotated Grant Agreement and using the template provided by the European Commission, where it will be detailed the type of data generated and all the required information on how data lifecycle will be handled. This DMP will be a living document throughout project implementation, updated and enriched every time necessary and if possible, will be registered as a non-restricted public deliverable to assure DMP publication. CHAngeing will produce research, personal and technical data which will be managed accordingly to the FAIR principle and following Horizon Europe guidelines.

Publications

Peer reviewed articles (18)

Adipose tissue-liver cross-talk: a route to hepatic dysfunction in pregnant women with obesity

Auteurs: Diana Sousa, Carina C. Magalhães, Paulo Matafome, Susana P. Pereira
Publié dans: Bioscience Reports, Numéro 44, 2024, ISSN 0144-8463
Éditeur: Portland Press Ltd.
DOI: 10.1042/BSR20231679

Ageing in Place: Older People Identify Barriers to Remaining in Low-Density Areas

Auteurs: Paulo Nossa; Sofia Vale Pereira; Margarida Lima; Cristina C. Vieira; Anabela Mota-Pinto
Publié dans: Journal of Population Ageing, 2024, ISSN 1874-7876
Éditeur: Springer
DOI: 10.1007/s12062-024-09449-6

A New Phenotype–Genotype Correlation for <scp>FIG4</scp> and Parkinson's Disease

Auteurs: Iro Boura, Panayiotis Mitsias, Sofia Erimaki, Efrosini Papadaki, Cleanthe Spanaki
Publié dans: Movement Disorders Clinical Practice, 2025, ISSN 2330-1619
Éditeur: Wiley
DOI: 10.1002/MDC3.70319

Study of the <i>NOTCH3</i> Gene Reveals the First CADASIL Cases in Crete and a Novel Pathogenic Variant

Auteurs: Ioannis Zaganas; Ioannis Tsiverdis; Evgenia Kokosali; Ionela Litso; Minas Drakos; Irene Skoula; Alexandros Zabetakis; Lambros Mathioudakis; Vassilios Mastorodemos; Panayiotis Mitsias
Publié dans: Brain and Behavior, 2025, ISSN 2162-3279
Éditeur: Wiley
DOI: 10.1002/BRB3.70789

Blood–brain barrier dysfunction in aging is mediated by brain endothelial senescence

Auteurs: João P. Novo; Lucy Gee; Carolina A. Caetano; Inês Tomé; Andreia Vilaça; Thomas von Zglinicki; Irina S. Moreira; Diana Jurk; Susana Rosa; Lino Ferreira
Publié dans: Aging Cell, 2024, ISSN 1474-9726
Éditeur: Willey
DOI: 10.1111/ACEL.14270

Cellular reprogramming as a tool to model human aging in a dish

Auteurs: Patrícia Pitrez, Luís M. Monteiro, Oliver Borgogno, Xavier Nissan, Jerome Mertens and Lino Ferreira
Publié dans: Nature Communications, 2024, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.1038/S41467-024-46004-5

Application of curcuminoids in inflammatory, neurodegenerative and aging conditions - Pharmacological potential and bioengineering approaches to improve efficiency

Auteurs: Ricardo Lagoa, Logesh Rajan, Cristiana Violante, Smith B. Babiaka, Dorinda Marques-da-Silva, Bhupinder Kapoor, Flávio Reis, Atanas G. Atanasov
Publié dans: Biotechnology Advances, Numéro 82, 2025, ISSN 0734-9750
Éditeur: Elsevier BV
DOI: 10.1016/J.BIOTECHADV.2025.108568

Caenorhabditis elegans as an emerging high throughput chronotherapeutic drug screening platform for human neurodegenerative disorders

Auteurs: Mrutyunjaya Panda, Maria Fakitsa, Maria Markaki, Nektarios Tavernarakis
Publié dans: Advanced Drug Delivery Reviews, Numéro 224, 2025, ISSN 0169-409X
Éditeur: Elsevier BV
DOI: 10.1016/J.ADDR.2025.115655

Incidence, prevalence and mortality of Parkinson’s disease in Greece

Auteurs: George Makris, Evangelia Samoli, Gregory Chlouverakis, Cleanthe Spanaki
Publié dans: Neurological Sciences, 2025, ISSN 1590-1874
Éditeur: Springer Science and Business Media LLC
DOI: 10.1007/S10072-025-08297-2

A surge in endogenous spermidine is essential for rapamycin-induced autophagy and longevity

Auteurs: Sebastian J. Hofer; Ioanna Daskalaki; Mahmoud Abdellatif; Ulrich Stelzl; Simon Sedej; Nektarios Tavernarakis; Guido Kroemer; Frank Madeo
Publié dans: Autophagy, 2024, ISSN 1554-8635
Éditeur: Taylor & Francis
DOI: 10.1080/15548627.2024.2396793

Glutamate-specific gene linked to human brain evolution enhances synaptic plasticity and cognitive processes

Auteurs: Cleanthe Spanaki; Kyriaki Sidiropoulou; Zoe Petraki; Konstantinos Diskos; Xanthippi Konstantoudaki; Emmanouela Volitaki; Konstantina Mylonaki; Maria Savvaki; Andreas Plaitakis
Publié dans: iScience, 2024, ISSN 2589-0042
Éditeur: Elsevier
DOI: 10.1016/j.isci.2024.108821

The senotherapeutic potential of phytochemicals for age-related intestinal disease

Auteurs: Costa, Célia Maria; Pedrosa, Sílvia Santos; Kirkland, James L; Reis, Flávio; Madureira, Raquel
Publié dans: Ageing Research Reviews, 2025, ISSN 1872-9649
Éditeur: Elsevier
DOI: 10.1016/J.ARR.2024.102619

Polyphenols: immunonutrients tipping the balance of immunometabolism in chronic diseases

Auteurs: Carolina Ferreira, Pedro Vieira, Helena Sá, João Malva, Miguel Castelo-Branco, Flávio Reis and Sofia Viana
Publié dans: Frontiers in Immunology, Numéro doi: doi.org/10.3389/fimmu.2024.1360065, 2024, ISSN 1664-3224
Éditeur: Frontiers
DOI: 10.3389/FIMMU.2024.1360065

Local coordination of mRNA storage anddegradation near mitochondria modulates C. elegans ageing

Auteurs: Ioanna Daskalaki, Maria Markaki, Ilias Gkikas and Nektarios Tavernarakis
Publié dans: EMBO Journal, Numéro doi: 10.15252/embj.2022112446, 2023, ISSN 2041-1723
Éditeur: Nature Publishing Group
DOI: 10.15252/EMBJ.2022112446

miRNA-642a-3p protects β cells from glucolipotoxicity

Auteurs: Sandra Sofia Pinhanços, João Teixeira de Oliveira, C. Henrique Alves, Cláudia M. Deus, Twan J.J. de Winter, Sofia Viana, Flávio Reis, Jorge Santos, Mijke Buitinga, Françoise Carlotti, Lino Ferreira, Martin Gotthardt, John Jones, Hugo Fernandes
Publié dans: Molecular Therapy Nucleic Acids, Numéro 36, 2025, ISSN 2162-2531
Éditeur: Elsevier BV
DOI: 10.1016/J.OMTN.2025.102498

Lipid-lowering statins and polyphenol-based supplementation: a scoping review on drug-food interaction potential

Auteurs: Rita Costa, Carolina Ferreira, André Alves, Sara Nunes, Flávio Reis, João Malva, Sofia Viana
Publié dans: Frontiers in Pharmacology, Numéro 16, 2025, ISSN 1663-9812
Éditeur: Frontiers Media SA
DOI: 10.3389/FPHAR.2025.1541871

Neurovascular dysfunction in psychiatric disorders: Underlying mechanisms and therapeutic approaches

Auteurs: Eliane Swely Sanches, Daniela Simões, Filipa Isabel Baptista, Ana Paula Silva
Publié dans: European Journal of Clinical Investigation, Numéro 55, 2024, ISSN 0014-2972
Éditeur: Wiley
DOI: 10.1111/eci.14319

Spermidine is essential for fasting-mediated autophagy and longevity

Auteurs: Sebastian J. Hofer; Ioanna Daskalaki; Martina Bergmann; Jasna Friščić; Andreas Zimmermann; Melanie I. Mueller; Mahmoud Abdellatif; Raffaele Nicastro; Sarah Masser; Sylvère Durand; Alexander Nartey; Mara Waltenstorfer; Sarah Enzenhofer; Isabella Faimann; Verena Gschiel; Thomas Bajaj; Christine Niemeyer; Ilias Gkikas; Lukas Pein; Giulia Cerrato; Hui Pan; YongTian Liang; Jelena Tadic; Andrea Jerkovic; Fanny Aprahamian; Christine E. Robbins; Nitharsshini Nirmalathasan; Hansjörg Habisch; Elisabeth Annerer; Frederik Dethloff; Michael Stumpe; Franziska Grundler; Françoise Wilhelmi de Toledo; Daniel E. Heinz; Daniela A. Koppold; Anika Rajput Khokhar; Andreas Michalsen; Norbert J. Tripolt; Harald Sourij; Thomas R. Pieber; Rafael de Cabo; Mark A. McCormick; Christoph Magnes; Oliver Kepp; Joern Dengjel; Stephan J. Sigrist; Nils C. Gassen; Simon Sedej; Tobias Madl; Claudio De Virgilio; Ulrich Stelzl; Markus H. Hoffmann; Tobias Eisenberg; Nektarios Tavernarakis; Guido Kroemer; Frank Madeo
Publié dans: Nature Cell Biology, 2024, ISSN 1476-4679
Éditeur: Nature Publishing Group
DOI: 10.1038/s41556-024-01468-x

Thesis and dissertations (2)

Pharmacological Strategies to Target Cellular Senescence

Auteurs: Inês Tomé Ribeiro
Publié dans: PhD thesis, 2024
Éditeur: University of Coimbra

Avaliação de estilos de vida saudáveis inspirados pela cultura da dieta mediterrânica - recurso a inovação tecnológica

Auteurs: Thomaz Peixoto Rossini
Publié dans: Master thesis, 2024
Éditeur: University of Coimbra

Book chapters (4)

Chapter 26 - Obesity and metabolic changes in neurodegenerative diseases

Auteurs: Diana Sousa, Beatriz Caramelo, Christos Tsatsanis, Miguel Castelo-Branco, Paulo Matafome
Éditeur: Elsevier

Chapter 18 - The impact of hypercaloric diet on inflammation and blood–brain barrier function

Auteurs: Filipa Isabel Baptista, Joana Margarida Gaspar, Catarina Muralha Leiria, Ana Rita Garcia, Maria Alexandra Brito, Ana Paula Silva
Éditeur: Elsevier

Chapter 16 - Neuroprotection and antiaging effects of caloric restriction

Auteurs: Roberto A. Dias, Catarina Mendes, Nuno Raimundo, Neuza Domingues
Éditeur: Elsevier

Chapter 17 - Neurovascular dysfunction, stroke, and age-related cognitive impairment: the benefits of the Mediterranean diet

Auteurs: Alexandros Zampetakis , Ioannis Zaganas, Ana Duarte, Débora Mena, Eliane Sanches, João O. Malva
Éditeur: Elsevier

Conference proceedings (1)

Recovery of insulin/IGF‐1/GLP‐1 signaling protects the brain against cardiometabolic and neurodegenerative diseases

Auteurs: Duarte, Ana Isabel
Publié dans: Alzheimer's &amp; Dementia, 2024
Éditeur: Wiley
DOI: 10.1002/ALZ.89823