Connected Hubs in Ageing: Healthy Living to Protect Cerebrovascular Function

Informazioni relative al progetto

CHAngeing

ID dell’accordo di sovvenzione: 101087071

DOI

10.3030/101087071

Data della firma CE 10 Novembre 2022

Data di avvio 1 Gennaio 2023

Data di completamento 31 Dicembre 2026

Finanziato da

• Widening participation and spreading excellence

Costo totale

€ 4 999 693,75

Contributo UE

€ 4 999 693,75

Coordinato da

UNIVERSIDADE DE COIMBRA
Portugal

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (4)

Conceptual design and pre-planning for pilot and demonstrator report

This report will reflect the work done by the multidisciplinary focus groups with experts and end-users to to co-create a new ICT instrumentalized toolkit for lifestyle assessment to prevent CVD based on Mediterranean diet culture; and to implement the preparatory steps, and institutional framework, for a demonstrator to highlight good practices and health outcomes from ICT-supported rehabilitation strategies of stroke survivors. The report will also address the proposed roadmap to identify and characterize the population cohorts to be involved in the appropriate pilots and demonstrators (territory mapping exercise contemplating urban and rural settings, located in Center Region of Portugal and in Crete).

CHAngeing educational portfolio

An innovative educational program will be developed, resulting from collaborative initiatives and synergies synergies between PhD programs in health and ageing-related topics based at the UoC/FORTH and UC, to train master’s and PhD students. The educational portfolio will reflect the high alignment with the scientific scope of the proposal on ageing and healthy lifestyles, with strong educational elements of innovation and entrepreneurship will be implemented.

Report on barriers, enablers and opportunities to adoption of ICT’s to support healthy lifestyles and CVD patients rehabilitation

This report will gather a systematic review regarding the barriers, enablers and opportunities for the use of ICT’s, such as digital health technologies reimbursement restrictions, that impair large-scale adoption or the ‘willingness-to-pay’ gap.

Communication, dissemination and exploitation plan

To deliver a communication, dissemination and exploitation plan based on Open Science practices to boost CHAngeing excellence hubs national and international visibility, containing details concerning communication and dissemination activities targeting: 1) high-impact scientific publications and attraction of new talents to both hubs; 2) citizens; 3) private funding, funding agencies, policymakers and other relevant stakeholders.

Data Management Plan (1)

Data Management Plan

The first project deliverable will be a Data Management Plan (DMP) aligned with the article 17 of the Annotated Grant Agreement and using the template provided by the European Commission, where it will be detailed the type of data generated and all the required information on how data lifecycle will be handled. This DMP will be a living document throughout project implementation, updated and enriched every time necessary and if possible, will be registered as a non-restricted public deliverable to assure DMP publication. CHAngeing will produce research, personal and technical data which will be managed accordingly to the FAIR principle and following Horizon Europe guidelines.

Pubblicazioni

Peer reviewed articles (18)

Adipose tissue-liver cross-talk: a route to hepatic dysfunction in pregnant women with obesity

Autori: Diana Sousa, Carina C. Magalhães, Paulo Matafome, Susana P. Pereira
Pubblicato in: Bioscience Reports, Numero 44, 2024, ISSN 0144-8463
Editore: Portland Press Ltd.
DOI: 10.1042/BSR20231679

Ageing in Place: Older People Identify Barriers to Remaining in Low-Density Areas

Autori: Paulo Nossa; Sofia Vale Pereira; Margarida Lima; Cristina C. Vieira; Anabela Mota-Pinto
Pubblicato in: Journal of Population Ageing, 2024, ISSN 1874-7876
Editore: Springer
DOI: 10.1007/s12062-024-09449-6

A New Phenotype–Genotype Correlation for <scp>FIG4</scp> and Parkinson's Disease

Autori: Iro Boura, Panayiotis Mitsias, Sofia Erimaki, Efrosini Papadaki, Cleanthe Spanaki
Pubblicato in: Movement Disorders Clinical Practice, 2025, ISSN 2330-1619
Editore: Wiley
DOI: 10.1002/MDC3.70319

Study of the <i>NOTCH3</i> Gene Reveals the First CADASIL Cases in Crete and a Novel Pathogenic Variant

Autori: Ioannis Zaganas; Ioannis Tsiverdis; Evgenia Kokosali; Ionela Litso; Minas Drakos; Irene Skoula; Alexandros Zabetakis; Lambros Mathioudakis; Vassilios Mastorodemos; Panayiotis Mitsias
Pubblicato in: Brain and Behavior, 2025, ISSN 2162-3279
Editore: Wiley
DOI: 10.1002/BRB3.70789

Blood–brain barrier dysfunction in aging is mediated by brain endothelial senescence

Autori: João P. Novo; Lucy Gee; Carolina A. Caetano; Inês Tomé; Andreia Vilaça; Thomas von Zglinicki; Irina S. Moreira; Diana Jurk; Susana Rosa; Lino Ferreira
Pubblicato in: Aging Cell, 2024, ISSN 1474-9726
Editore: Willey
DOI: 10.1111/ACEL.14270

Cellular reprogramming as a tool to model human aging in a dish

Autori: Patrícia Pitrez, Luís M. Monteiro, Oliver Borgogno, Xavier Nissan, Jerome Mertens and Lino Ferreira
Pubblicato in: Nature Communications, 2024, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.1038/S41467-024-46004-5

Application of curcuminoids in inflammatory, neurodegenerative and aging conditions - Pharmacological potential and bioengineering approaches to improve efficiency

Autori: Ricardo Lagoa, Logesh Rajan, Cristiana Violante, Smith B. Babiaka, Dorinda Marques-da-Silva, Bhupinder Kapoor, Flávio Reis, Atanas G. Atanasov
Pubblicato in: Biotechnology Advances, Numero 82, 2025, ISSN 0734-9750
Editore: Elsevier BV
DOI: 10.1016/J.BIOTECHADV.2025.108568

Caenorhabditis elegans as an emerging high throughput chronotherapeutic drug screening platform for human neurodegenerative disorders

Autori: Mrutyunjaya Panda, Maria Fakitsa, Maria Markaki, Nektarios Tavernarakis
Pubblicato in: Advanced Drug Delivery Reviews, Numero 224, 2025, ISSN 0169-409X
Editore: Elsevier BV
DOI: 10.1016/J.ADDR.2025.115655

Incidence, prevalence and mortality of Parkinson’s disease in Greece

Autori: George Makris, Evangelia Samoli, Gregory Chlouverakis, Cleanthe Spanaki
Pubblicato in: Neurological Sciences, 2025, ISSN 1590-1874
Editore: Springer Science and Business Media LLC
DOI: 10.1007/S10072-025-08297-2

A surge in endogenous spermidine is essential for rapamycin-induced autophagy and longevity

Autori: Sebastian J. Hofer; Ioanna Daskalaki; Mahmoud Abdellatif; Ulrich Stelzl; Simon Sedej; Nektarios Tavernarakis; Guido Kroemer; Frank Madeo
Pubblicato in: Autophagy, 2024, ISSN 1554-8635
Editore: Taylor & Francis
DOI: 10.1080/15548627.2024.2396793

Glutamate-specific gene linked to human brain evolution enhances synaptic plasticity and cognitive processes

Autori: Cleanthe Spanaki; Kyriaki Sidiropoulou; Zoe Petraki; Konstantinos Diskos; Xanthippi Konstantoudaki; Emmanouela Volitaki; Konstantina Mylonaki; Maria Savvaki; Andreas Plaitakis
Pubblicato in: iScience, 2024, ISSN 2589-0042
Editore: Elsevier
DOI: 10.1016/j.isci.2024.108821

The senotherapeutic potential of phytochemicals for age-related intestinal disease

Autori: Costa, Célia Maria; Pedrosa, Sílvia Santos; Kirkland, James L; Reis, Flávio; Madureira, Raquel
Pubblicato in: Ageing Research Reviews, 2025, ISSN 1872-9649
Editore: Elsevier
DOI: 10.1016/J.ARR.2024.102619

Polyphenols: immunonutrients tipping the balance of immunometabolism in chronic diseases

Autori: Carolina Ferreira, Pedro Vieira, Helena Sá, João Malva, Miguel Castelo-Branco, Flávio Reis and Sofia Viana
Pubblicato in: Frontiers in Immunology, Numero doi: doi.org/10.3389/fimmu.2024.1360065, 2024, ISSN 1664-3224
Editore: Frontiers
DOI: 10.3389/FIMMU.2024.1360065

Local coordination of mRNA storage anddegradation near mitochondria modulates C. elegans ageing

Autori: Ioanna Daskalaki, Maria Markaki, Ilias Gkikas and Nektarios Tavernarakis
Pubblicato in: EMBO Journal, Numero doi: 10.15252/embj.2022112446, 2023, ISSN 2041-1723
Editore: Nature Publishing Group
DOI: 10.15252/EMBJ.2022112446

miRNA-642a-3p protects β cells from glucolipotoxicity

Autori: Sandra Sofia Pinhanços, João Teixeira de Oliveira, C. Henrique Alves, Cláudia M. Deus, Twan J.J. de Winter, Sofia Viana, Flávio Reis, Jorge Santos, Mijke Buitinga, Françoise Carlotti, Lino Ferreira, Martin Gotthardt, John Jones, Hugo Fernandes
Pubblicato in: Molecular Therapy Nucleic Acids, Numero 36, 2025, ISSN 2162-2531
Editore: Elsevier BV
DOI: 10.1016/J.OMTN.2025.102498

Lipid-lowering statins and polyphenol-based supplementation: a scoping review on drug-food interaction potential

Autori: Rita Costa, Carolina Ferreira, André Alves, Sara Nunes, Flávio Reis, João Malva, Sofia Viana
Pubblicato in: Frontiers in Pharmacology, Numero 16, 2025, ISSN 1663-9812
Editore: Frontiers Media SA
DOI: 10.3389/FPHAR.2025.1541871

Neurovascular dysfunction in psychiatric disorders: Underlying mechanisms and therapeutic approaches

Autori: Eliane Swely Sanches, Daniela Simões, Filipa Isabel Baptista, Ana Paula Silva
Pubblicato in: European Journal of Clinical Investigation, Numero 55, 2024, ISSN 0014-2972
Editore: Wiley
DOI: 10.1111/eci.14319

Spermidine is essential for fasting-mediated autophagy and longevity

Autori: Sebastian J. Hofer; Ioanna Daskalaki; Martina Bergmann; Jasna Friščić; Andreas Zimmermann; Melanie I. Mueller; Mahmoud Abdellatif; Raffaele Nicastro; Sarah Masser; Sylvère Durand; Alexander Nartey; Mara Waltenstorfer; Sarah Enzenhofer; Isabella Faimann; Verena Gschiel; Thomas Bajaj; Christine Niemeyer; Ilias Gkikas; Lukas Pein; Giulia Cerrato; Hui Pan; YongTian Liang; Jelena Tadic; Andrea Jerkovic; Fanny Aprahamian; Christine E. Robbins; Nitharsshini Nirmalathasan; Hansjörg Habisch; Elisabeth Annerer; Frederik Dethloff; Michael Stumpe; Franziska Grundler; Françoise Wilhelmi de Toledo; Daniel E. Heinz; Daniela A. Koppold; Anika Rajput Khokhar; Andreas Michalsen; Norbert J. Tripolt; Harald Sourij; Thomas R. Pieber; Rafael de Cabo; Mark A. McCormick; Christoph Magnes; Oliver Kepp; Joern Dengjel; Stephan J. Sigrist; Nils C. Gassen; Simon Sedej; Tobias Madl; Claudio De Virgilio; Ulrich Stelzl; Markus H. Hoffmann; Tobias Eisenberg; Nektarios Tavernarakis; Guido Kroemer; Frank Madeo
Pubblicato in: Nature Cell Biology, 2024, ISSN 1476-4679
Editore: Nature Publishing Group
DOI: 10.1038/s41556-024-01468-x

Thesis and dissertations (2)

Pharmacological Strategies to Target Cellular Senescence

Autori: Inês Tomé Ribeiro
Pubblicato in: PhD thesis, 2024
Editore: University of Coimbra

Avaliação de estilos de vida saudáveis inspirados pela cultura da dieta mediterrânica - recurso a inovação tecnológica

Autori: Thomaz Peixoto Rossini
Pubblicato in: Master thesis, 2024
Editore: University of Coimbra

Book chapters (4)

Chapter 26 - Obesity and metabolic changes in neurodegenerative diseases

Autori: Diana Sousa, Beatriz Caramelo, Christos Tsatsanis, Miguel Castelo-Branco, Paulo Matafome
Editore: Elsevier

Chapter 18 - The impact of hypercaloric diet on inflammation and blood–brain barrier function

Autori: Filipa Isabel Baptista, Joana Margarida Gaspar, Catarina Muralha Leiria, Ana Rita Garcia, Maria Alexandra Brito, Ana Paula Silva
Editore: Elsevier

Chapter 16 - Neuroprotection and antiaging effects of caloric restriction

Autori: Roberto A. Dias, Catarina Mendes, Nuno Raimundo, Neuza Domingues
Editore: Elsevier

Chapter 17 - Neurovascular dysfunction, stroke, and age-related cognitive impairment: the benefits of the Mediterranean diet

Autori: Alexandros Zampetakis , Ioannis Zaganas, Ana Duarte, Débora Mena, Eliane Sanches, João O. Malva
Editore: Elsevier

Conference proceedings (1)

Recovery of insulin/IGF‐1/GLP‐1 signaling protects the brain against cardiometabolic and neurodegenerative diseases

Autori: Duarte, Ana Isabel
Pubblicato in: Alzheimer's &amp; Dementia, 2024
Editore: Wiley
DOI: 10.1002/ALZ.89823