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CORDIS - EU research results
CORDIS

Connected Hubs in Ageing: Healthy Living to Protect Cerebrovascular Function

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Conceptual design and pre-planning for pilot and demonstrator report (opens in new window)

This report will reflect the work done by the multidisciplinary focus groups with experts and end-users to to co-create a new ICT instrumentalized toolkit for lifestyle assessment to prevent CVD based on Mediterranean diet culture; and to implement the preparatory steps, and institutional framework, for a demonstrator to highlight good practices and health outcomes from ICT-supported rehabilitation strategies of stroke survivors. The report will also address the proposed roadmap to identify and characterize the population cohorts to be involved in the appropriate pilots and demonstrators (territory mapping exercise contemplating urban and rural settings, located in Center Region of Portugal and in Crete).

CHAngeing educational portfolio (opens in new window)

An innovative educational program will be developed, resulting from collaborative initiatives and synergies synergies between PhD programs in health and ageing-related topics based at the UoC/FORTH and UC, to train master’s and PhD students. The educational portfolio will reflect the high alignment with the scientific scope of the proposal on ageing and healthy lifestyles, with strong educational elements of innovation and entrepreneurship will be implemented.

Report on barriers, enablers and opportunities to adoption of ICT’s to support healthy lifestyles and CVD patients rehabilitation (opens in new window)

This report will gather a systematic review regarding the barriers, enablers and opportunities for the use of ICT’s, such as digital health technologies reimbursement restrictions, that impair large-scale adoption or the ‘willingness-to-pay’ gap.

Communication, dissemination and exploitation plan (opens in new window)

To deliver a communication, dissemination and exploitation plan based on Open Science practices to boost CHAngeing excellence hubs national and international visibility, containing details concerning communication and dissemination activities targeting: 1) high-impact scientific publications and attraction of new talents to both hubs; 2) citizens; 3) private funding, funding agencies, policymakers and other relevant stakeholders.

Data Management Plan (opens in new window)

The first project deliverable will be a Data Management Plan (DMP) aligned with the article 17 of the Annotated Grant Agreement and using the template provided by the European Commission, where it will be detailed the type of data generated and all the required information on how data lifecycle will be handled. This DMP will be a living document throughout project implementation, updated and enriched every time necessary and if possible, will be registered as a non-restricted public deliverable to assure DMP publication. CHAngeing will produce research, personal and technical data which will be managed accordingly to the FAIR principle and following Horizon Europe guidelines.

Publications

Adipose tissue-liver cross-talk: a route to hepatic dysfunction in pregnant women with obesity (opens in new window)

Author(s): Diana Sousa, Carina C. Magalhães, Paulo Matafome, Susana P. Pereira
Published in: Bioscience Reports, Issue 44, 2024, ISSN 0144-8463
Publisher: Portland Press Ltd.
DOI: 10.1042/BSR20231679

Ageing in Place: Older People Identify Barriers to Remaining in Low-Density Areas (opens in new window)

Author(s): Paulo Nossa; Sofia Vale Pereira; Margarida Lima; Cristina C. Vieira; Anabela Mota-Pinto
Published in: Journal of Population Ageing, 2024, ISSN 1874-7876
Publisher: Springer
DOI: 10.1007/s12062-024-09449-6

A New Phenotype–Genotype Correlation for <scp>FIG4</scp> and Parkinson's Disease (opens in new window)

Author(s): Iro Boura, Panayiotis Mitsias, Sofia Erimaki, Efrosini Papadaki, Cleanthe Spanaki
Published in: Movement Disorders Clinical Practice, 2025, ISSN 2330-1619
Publisher: Wiley
DOI: 10.1002/MDC3.70319

Study of the <i>NOTCH3</i> Gene Reveals the First CADASIL Cases in Crete and a Novel Pathogenic Variant (opens in new window)

Author(s): Ioannis Zaganas; Ioannis Tsiverdis; Evgenia Kokosali; Ionela Litso; Minas Drakos; Irene Skoula; Alexandros Zabetakis; Lambros Mathioudakis; Vassilios Mastorodemos; Panayiotis Mitsias
Published in: Brain and Behavior, 2025, ISSN 2162-3279
Publisher: Wiley
DOI: 10.1002/BRB3.70789

Blood–brain barrier dysfunction in aging is mediated by brain endothelial senescence (opens in new window)

Author(s): João P. Novo; Lucy Gee; Carolina A. Caetano; Inês Tomé; Andreia Vilaça; Thomas von Zglinicki; Irina S. Moreira; Diana Jurk; Susana Rosa; Lino Ferreira
Published in: Aging Cell, 2024, ISSN 1474-9726
Publisher: Willey
DOI: 10.1111/ACEL.14270

Cellular reprogramming as a tool to model human aging in a dish (opens in new window)

Author(s): Patrícia Pitrez, Luís M. Monteiro, Oliver Borgogno, Xavier Nissan, Jerome Mertens and Lino Ferreira
Published in: Nature Communications, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/S41467-024-46004-5

Application of curcuminoids in inflammatory, neurodegenerative and aging conditions - Pharmacological potential and bioengineering approaches to improve efficiency (opens in new window)

Author(s): Ricardo Lagoa, Logesh Rajan, Cristiana Violante, Smith B. Babiaka, Dorinda Marques-da-Silva, Bhupinder Kapoor, Flávio Reis, Atanas G. Atanasov
Published in: Biotechnology Advances, Issue 82, 2025, ISSN 0734-9750
Publisher: Elsevier BV
DOI: 10.1016/J.BIOTECHADV.2025.108568

Caenorhabditis elegans as an emerging high throughput chronotherapeutic drug screening platform for human neurodegenerative disorders (opens in new window)

Author(s): Mrutyunjaya Panda, Maria Fakitsa, Maria Markaki, Nektarios Tavernarakis
Published in: Advanced Drug Delivery Reviews, Issue 224, 2025, ISSN 0169-409X
Publisher: Elsevier BV
DOI: 10.1016/J.ADDR.2025.115655

Incidence, prevalence and mortality of Parkinson’s disease in Greece (opens in new window)

Author(s): George Makris, Evangelia Samoli, Gregory Chlouverakis, Cleanthe Spanaki
Published in: Neurological Sciences, 2025, ISSN 1590-1874
Publisher: Springer Science and Business Media LLC
DOI: 10.1007/S10072-025-08297-2

A surge in endogenous spermidine is essential for rapamycin-induced autophagy and longevity (opens in new window)

Author(s): Sebastian J. Hofer; Ioanna Daskalaki; Mahmoud Abdellatif; Ulrich Stelzl; Simon Sedej; Nektarios Tavernarakis; Guido Kroemer; Frank Madeo
Published in: Autophagy, 2024, ISSN 1554-8635
Publisher: Taylor & Francis
DOI: 10.1080/15548627.2024.2396793

Glutamate-specific gene linked to human brain evolution enhances synaptic plasticity and cognitive processes (opens in new window)

Author(s): Cleanthe Spanaki; Kyriaki Sidiropoulou; Zoe Petraki; Konstantinos Diskos; Xanthippi Konstantoudaki; Emmanouela Volitaki; Konstantina Mylonaki; Maria Savvaki; Andreas Plaitakis
Published in: iScience, 2024, ISSN 2589-0042
Publisher: Elsevier
DOI: 10.1016/j.isci.2024.108821

The senotherapeutic potential of phytochemicals for age-related intestinal disease (opens in new window)

Author(s): Costa, Célia Maria; Pedrosa, Sílvia Santos; Kirkland, James L; Reis, Flávio; Madureira, Raquel
Published in: Ageing Research Reviews, 2025, ISSN 1872-9649
Publisher: Elsevier
DOI: 10.1016/J.ARR.2024.102619

Polyphenols: immunonutrients tipping the balance of immunometabolism in chronic diseases (opens in new window)

Author(s): Carolina Ferreira, Pedro Vieira, Helena Sá, João Malva, Miguel Castelo-Branco, Flávio Reis and Sofia Viana
Published in: Frontiers in Immunology, Issue doi: doi.org/10.3389/fimmu.2024.1360065, 2024, ISSN 1664-3224
Publisher: Frontiers
DOI: 10.3389/FIMMU.2024.1360065

Local coordination of mRNA storage anddegradation near mitochondria modulates C. elegans ageing (opens in new window)

Author(s): Ioanna Daskalaki, Maria Markaki, Ilias Gkikas and Nektarios Tavernarakis
Published in: EMBO Journal, Issue doi: 10.15252/embj.2022112446, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.15252/EMBJ.2022112446

miRNA-642a-3p protects β cells from glucolipotoxicity (opens in new window)

Author(s): Sandra Sofia Pinhanços, João Teixeira de Oliveira, C. Henrique Alves, Cláudia M. Deus, Twan J.J. de Winter, Sofia Viana, Flávio Reis, Jorge Santos, Mijke Buitinga, Françoise Carlotti, Lino Ferreira, Martin Gotthardt, John Jones, Hugo Fernandes
Published in: Molecular Therapy Nucleic Acids, Issue 36, 2025, ISSN 2162-2531
Publisher: Elsevier BV
DOI: 10.1016/J.OMTN.2025.102498

Lipid-lowering statins and polyphenol-based supplementation: a scoping review on drug-food interaction potential (opens in new window)

Author(s): Rita Costa, Carolina Ferreira, André Alves, Sara Nunes, Flávio Reis, João Malva, Sofia Viana
Published in: Frontiers in Pharmacology, Issue 16, 2025, ISSN 1663-9812
Publisher: Frontiers Media SA
DOI: 10.3389/FPHAR.2025.1541871

Neurovascular dysfunction in psychiatric disorders: Underlying mechanisms and therapeutic approaches (opens in new window)

Author(s): Eliane Swely Sanches, Daniela Simões, Filipa Isabel Baptista, Ana Paula Silva
Published in: European Journal of Clinical Investigation, Issue 55, 2024, ISSN 0014-2972
Publisher: Wiley
DOI: 10.1111/eci.14319

Spermidine is essential for fasting-mediated autophagy and longevity (opens in new window)

Author(s): Sebastian J. Hofer; Ioanna Daskalaki; Martina Bergmann; Jasna Friščić; Andreas Zimmermann; Melanie I. Mueller; Mahmoud Abdellatif; Raffaele Nicastro; Sarah Masser; Sylvère Durand; Alexander Nartey; Mara Waltenstorfer; Sarah Enzenhofer; Isabella Faimann; Verena Gschiel; Thomas Bajaj; Christine Niemeyer; Ilias Gkikas; Lukas Pein; Giulia Cerrato; Hui Pan; YongTian Liang; Jelena Tadic; Andrea Jerkovic; Fanny Aprahamian; Christine E. Robbins; Nitharsshini Nirmalathasan; Hansjörg Habisch; Elisabeth Annerer; Frederik Dethloff; Michael Stumpe; Franziska Grundler; Françoise Wilhelmi de Toledo; Daniel E. Heinz; Daniela A. Koppold; Anika Rajput Khokhar; Andreas Michalsen; Norbert J. Tripolt; Harald Sourij; Thomas R. Pieber; Rafael de Cabo; Mark A. McCormick; Christoph Magnes; Oliver Kepp; Joern Dengjel; Stephan J. Sigrist; Nils C. Gassen; Simon Sedej; Tobias Madl; Claudio De Virgilio; Ulrich Stelzl; Markus H. Hoffmann; Tobias Eisenberg; Nektarios Tavernarakis; Guido Kroemer; Frank Madeo
Published in: Nature Cell Biology, 2024, ISSN 1476-4679
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-024-01468-x

Pharmacological Strategies to Target Cellular Senescence

Author(s): Inês Tomé Ribeiro
Published in: PhD thesis, 2024
Publisher: University of Coimbra

Avaliação de estilos de vida saudáveis inspirados pela cultura da dieta mediterrânica - recurso a inovação tecnológica

Author(s): Thomaz Peixoto Rossini
Published in: Master thesis, 2024
Publisher: University of Coimbra

Chapter 26 - Obesity and metabolic changes in neurodegenerative diseases

Author(s): Diana Sousa, Beatriz Caramelo, Christos Tsatsanis, Miguel Castelo-Branco, Paulo Matafome
Publisher: Elsevier

Chapter 18 - The impact of hypercaloric diet on inflammation and blood–brain barrier function

Author(s): Filipa Isabel Baptista, Joana Margarida Gaspar, Catarina Muralha Leiria, Ana Rita Garcia, Maria Alexandra Brito, Ana Paula Silva
Publisher: Elsevier

Chapter 16 - Neuroprotection and antiaging effects of caloric restriction

Author(s): Roberto A. Dias, Catarina Mendes, Nuno Raimundo, Neuza Domingues
Publisher: Elsevier

Chapter 17 - Neurovascular dysfunction, stroke, and age-related cognitive impairment: the benefits of the Mediterranean diet

Author(s): Alexandros Zampetakis , Ioannis Zaganas, Ana Duarte, Débora Mena, Eliane Sanches, João O. Malva
Publisher: Elsevier

Recovery of insulin/IGF‐1/GLP‐1 signaling protects the brain against cardiometabolic and neurodegenerative diseases (opens in new window)

Author(s): Duarte, Ana Isabel
Published in: Alzheimer's &amp; Dementia, 2024
Publisher: Wiley
DOI: 10.1002/ALZ.89823

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