Connected Hubs in Ageing: Healthy Living to Protect Cerebrovascular Function

Leistungen

Conceptual design and pre-planning for pilot and demonstrator report

This report will reflect the work done by the multidisciplinary focus groups with experts and end-users to to co-create a new ICT instrumentalized toolkit for lifestyle assessment to prevent CVD based on Mediterranean diet culture; and to implement the preparatory steps, and institutional framework, for a demonstrator to highlight good practices and health outcomes from ICT-supported rehabilitation strategies of stroke survivors. The report will also address the proposed roadmap to identify and characterize the population cohorts to be involved in the appropriate pilots and demonstrators (territory mapping exercise contemplating urban and rural settings, located in Center Region of Portugal and in Crete).

CHAngeing educational portfolio

An innovative educational program will be developed, resulting from collaborative initiatives and synergies synergies between PhD programs in health and ageing-related topics based at the UoC/FORTH and UC, to train master’s and PhD students. The educational portfolio will reflect the high alignment with the scientific scope of the proposal on ageing and healthy lifestyles, with strong educational elements of innovation and entrepreneurship will be implemented.

Report on barriers, enablers and opportunities to adoption of ICT’s to support healthy lifestyles and CVD patients rehabilitation

This report will gather a systematic review regarding the barriers, enablers and opportunities for the use of ICT’s, such as digital health technologies reimbursement restrictions, that impair large-scale adoption or the ‘willingness-to-pay’ gap.

Communication, dissemination and exploitation plan

To deliver a communication, dissemination and exploitation plan based on Open Science practices to boost CHAngeing excellence hubs national and international visibility, containing details concerning communication and dissemination activities targeting: 1) high-impact scientific publications and attraction of new talents to both hubs; 2) citizens; 3) private funding, funding agencies, policymakers and other relevant stakeholders.

Data Management Plan

The first project deliverable will be a Data Management Plan (DMP) aligned with the article 17 of the Annotated Grant Agreement and using the template provided by the European Commission, where it will be detailed the type of data generated and all the required information on how data lifecycle will be handled. This DMP will be a living document throughout project implementation, updated and enriched every time necessary and if possible, will be registered as a non-restricted public deliverable to assure DMP publication. CHAngeing will produce research, personal and technical data which will be managed accordingly to the FAIR principle and following Horizon Europe guidelines.

Veröffentlichungen

Caenorhabditis elegans as an emerging high throughput chronotherapeutic drug screening platform for human neurodegenerative disorders

Autoren: Panda, Mrutyunjaya; Fakitsa, Maria; Markaki, Maria; Tavernarakis, Nektarios
Veröffentlicht in: Advanced Drug Delivery Reviews, 2025, ISSN 1872-8294
Herausgeber: Elsevier
DOI: 10.1016/J.ADDR.2025.115655

Adipose tissue-liver cross-talk: a route to hepatic dysfunction in pregnant women with obesity

Autoren: Diana Sousa, Carina C. Magalhães, Paulo Matafome, Susana P. Pereira
Veröffentlicht in: Bioscience Reports, Ausgabe 44, 2024, ISSN 0144-8463
Herausgeber: Portland Press Ltd.
DOI: 10.1042/BSR20231679

Ageing in Place: Older People Identify Barriers to Remaining in Low-Density Areas

Autoren: Paulo Nossa; Sofia Vale Pereira; Margarida Lima; Cristina C. Vieira; Anabela Mota-Pinto
Veröffentlicht in: Journal of Population Ageing, 2024, ISSN 1874-7876
Herausgeber: Springer
DOI: 10.1007/s12062-024-09449-6

A New Phenotype–Genotype Correlation for <scp>FIG4</scp> and Parkinson's Disease

Autoren: Iro Boura, Panayiotis Mitsias, Sofia Erimaki, Efrosini Papadaki, Cleanthe Spanaki
Veröffentlicht in: Movement Disorders Clinical Practice, 2025, ISSN 2330-1619
Herausgeber: Wiley
DOI: 10.1002/MDC3.70319

Blood–brain barrier dysfunction in aging is mediated by brain endothelial senescence

Autoren: João P. Novo; Lucy Gee; Carolina A. Caetano; Inês Tomé; Andreia Vilaça; Thomas von Zglinicki; Irina S. Moreira; Diana Jurk; Susana Rosa; Lino Ferreira
Veröffentlicht in: Aging Cell, 2024, ISSN 1474-9726
Herausgeber: Willey
DOI: 10.1111/ACEL.14270

Nature Communications

Autoren: Patrícia Pitrez, Luís M. Monteiro, Oliver Borgogno, Xavier Nissan, Jerome Mertens and Lino Ferreira
Veröffentlicht in: Nature Communications, Ausgabe doi.org/10.1038/s41467-024-46004-5, 2024, ISSN 2041-1723
Herausgeber: Nature Publishing Group
DOI: 10.1038/S41467-024-46004-5

The senotherapeutic potential of phytochemicals for age-related intestinal disease

Autoren: Costa CM, Pedrosa SS, Kirkland JL, Reis F, Madureira AR
Veröffentlicht in: Ageing Res Rev, Ausgabe 104:102619, 2024, ISSN 1872-9649
Herausgeber: Elsevier
DOI: 10.1016/j.arr.2024.102619.

Caenorhabditis elegans as an emerging high throughput chronotherapeutic drug screening platform for human neurodegenerative disorders

Autoren: Mrutyunjaya Panda, Maria Fakitsa, Maria Markaki, Nektarios Tavernarakis
Veröffentlicht in: Advanced Drug Delivery Reviews, Ausgabe 224, 2025, ISSN 0169-409X
Herausgeber: Elsevier BV
DOI: 10.1016/J.ADDR.2025.115655

Incidence, prevalence and mortality of Parkinson’s disease in Greece

Autoren: George Makris, Evangelia Samoli, Gregory Chlouverakis, Cleanthe Spanaki
Veröffentlicht in: Neurological Sciences, 2025, ISSN 1590-1874
Herausgeber: Springer Science and Business Media LLC
DOI: 10.1007/S10072-025-08297-2

A surge in endogenous spermidine is essential for rapamycin-induced autophagy and longevity

Autoren: Sebastian J. Hofer; Ioanna Daskalaki; Mahmoud Abdellatif; Ulrich Stelzl; Simon Sedej; Nektarios Tavernarakis; Guido Kroemer; Frank Madeo
Veröffentlicht in: Autophagy, 2024, ISSN 1554-8635
Herausgeber: Taylor & Francis
DOI: 10.1080/15548627.2024.2396793

Glutamate-specific gene linked to human brain evolution enhances synaptic plasticity and cognitive processes

Autoren: Cleanthe Spanaki; Kyriaki Sidiropoulou; Zoe Petraki; Konstantinos Diskos; Xanthippi Konstantoudaki; Emmanouela Volitaki; Konstantina Mylonaki; Maria Savvaki; Andreas Plaitakis
Veröffentlicht in: iScience, 2024, ISSN 2589-0042
Herausgeber: Elsevier
DOI: 10.1016/j.isci.2024.108821

Incidence, prevalence and mortality of Parkinson’s disease in Greece

Autoren: George Makris, Evangelia Samoli, Gregory Chlouverakis, Cleanthe Spanaki
Veröffentlicht in: Neurological Sciences, 2025, ISSN 1590-1874
Herausgeber: Springer Science and Business Media LLC
DOI: 10.1007/S10072-025-08297-2

Nature Communications

Autoren: Ioanna Daskalaki, Maria Markaki, Ilias Gkikas and Nektarios Tavernarakis
Veröffentlicht in: EMBO Journal, Ausgabe doi: 10.15252/embj.2022112446, 2023, ISSN 2041-1723
Herausgeber: Nature Publishing Group
DOI: 10.15252/EMBJ.2022112446

Neurovascular dysfunction in psychiatric disorders: Underlying mechanisms and therapeutic approaches

Autoren: Eliane Swely Sanches, Daniela Simões, Filipa Isabel Baptista, Ana Paula Silva
Veröffentlicht in: European Journal of Clinical Investigation, Ausgabe 55, 2024, ISSN 0014-2972
Herausgeber: Wiley
DOI: 10.1111/eci.14319

Spermidine is essential for fasting-mediated autophagy and longevity

Autoren: Sebastian J. Hofer; Ioanna Daskalaki; Martina Bergmann; Jasna Friščić; Andreas Zimmermann; Melanie I. Mueller; Mahmoud Abdellatif; Raffaele Nicastro; Sarah Masser; Sylvère Durand; Alexander Nartey; Mara Waltenstorfer; Sarah Enzenhofer; Isabella Faimann; Verena Gschiel; Thomas Bajaj; Christine Niemeyer; Ilias Gkikas; Lukas Pein; Giulia Cerrato; Hui Pan; YongTian Liang; Jelena Tadic; Andrea Jerkovic; Fanny Aprahamian; Christine E. Robbins; Nitharsshini Nirmalathasan; Hansjörg Habisch; Elisabeth Annerer; Frederik Dethloff; Michael Stumpe; Franziska Grundler; Françoise Wilhelmi de Toledo; Daniel E. Heinz; Daniela A. Koppold; Anika Rajput Khokhar; Andreas Michalsen; Norbert J. Tripolt; Harald Sourij; Thomas R. Pieber; Rafael de Cabo; Mark A. McCormick; Christoph Magnes; Oliver Kepp; Joern Dengjel; Stephan J. Sigrist; Nils C. Gassen; Simon Sedej; Tobias Madl; Claudio De Virgilio; Ulrich Stelzl; Markus H. Hoffmann; Tobias Eisenberg; Nektarios Tavernarakis; Guido Kroemer; Frank Madeo
Veröffentlicht in: Nature Cell Biology, 2024, ISSN 1476-4679
Herausgeber: Nature Publishing Group
DOI: 10.1038/s41556-024-01468-x

Pharmacological Strategies to Target Cellular Senescence

Autoren: Inês Tomé Ribeiro
Veröffentlicht in: PhD thesis, 2024
Herausgeber: University of Coimbra

Avaliação de estilos de vida saudáveis inspirados pela cultura da dieta mediterrânica - recurso a inovação tecnológica

Autoren: Thomaz Peixoto Rossini
Veröffentlicht in: Master thesis, 2024
Herausgeber: University of Coimbra

Leistungen

Veröffentlichungen

Diese Seite teilen Diese Seite in sozialen Netzwerken teilen

Herunterladen Den Inhalt der Seite herunterladen