Personalised pharmacometabolomic optimisation of treatment for hypertension

Project Information

Hypermarker

Grant agreement ID: 101095480

DOI

10.3030/101095480

EC signature date 8 December 2022

Start date 1 January 2023

End date 31 December 2026

Funded under

• Health

Total cost

€ 8 046 250,00

EU contribution

€ 8 046 250,00

Coordinated by

UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Data Management Plan (1)

Data management plan

Documents, reports (2)

Validation report of extended metabolomics/exposomics platform
Plan for dissemination and communication activities

Websites, patent fillings, videos etc. (1)

Project website

Publications

Peer reviewed articles (19)

Data source and utilization of artificial intelligence technologies in vascular surgery—a scoping review

Author(s): Katarzyna Powezka; Katarzyna Powezka; Katarzyna Powezka; Karin Slater; David Brind; Michael Wall; Michael Wall; Georgios Gkoutos; Maciej Juszczak; Maciej Juszczak
Published in: Frontiers in Cardiovascular Medicine, 2025, ISSN 2297-055X
Publisher: Frontiers Media
DOI: 10.3389/FCVM.2025.1497822

Blood-based cardiometabolic phenotypes in atrial fibrillation and their associated risk: EAST-AFNET 4 biomolecule study

Author(s): Larissa Fabritz; Winnie Chua; Victor R Cardoso; Christoph Al-Taie; Katrin Borof; Anna Suling; Linda Krause; Shinwan Kany; Christina Magnussen; Karl Wegscheider; Guenter Breithardt; Harry J G M Crijns; A John Camm; George Gkoutos; Patrick T Ellinor; Andreas Goette; Ulrich Schotten; Ursula-Henrike Wienhues-Thelen; Tanja Zeller; Renate B Schnabel; Antonia Zapf; Paulus Kirchhof
Published in: Cardiovascular Research, 2024, ISSN 1755-3245
Publisher: Oxford University Press
DOI: 10.1093/CVR/CVAE067

Towards responsible surveillance in preventive health data-AI research

Author(s): Sam H. A. Muller, Johannes J. M. van Delden, Ghislaine J. M. W. van Thiel, null null
Published in: PLOS Digital Health, Issue 4, 2025, ISSN 2767-3170
Publisher: Public Library of Science (PLoS)
DOI: 10.1371/JOURNAL.PDIG.0001146

Explainable AI-prioritized plasma and fecal metabolites in inflammatory bowel disease and their dietary associations

Author(s): Serena Onwuka; Laura Bravo-Merodio; Georgios V. Gkoutos; Animesh Acharjee
Published in: iScience, 2024, ISSN 2589-0042
Publisher: Cell Press
DOI: 10.1016/J.ISCI.2024.110298

A computational framework for inferring species dynamics and interactions with applications in microbiota ecology

Author(s): Xu, Yuanwei; Gkoutos, Georgios V.
Published in: npj Systems Biology and Applications, 2025, ISSN 2056-7189
Publisher: Nature Portfolio
DOI: 10.1038/S41540-025-00568-0

High hypoxia status in pancreatic cancer is associated with multiple hallmarks of an immunosuppressive tumor microenvironment

Author(s): Hassan Sadozai; Animesh Acharjee; Hateem Z. Kayani; Thomas Gruber; Reginald M. Gorczynski; Bernard Burke
Published in: Frontiers in Immunology, 2024, ISSN 2297-055X
Publisher: Frontiers Media
DOI: 10.3389/FIMMU.2024.1360629

Genetic architecture of hypertrophic cardiomyopathy in individuals of Chinese and United Kingdom ancestry

Author(s): Jie Wang; Dominic Russ; Yongsan Yang; Lutong Pu; Mengdi Yu; Jinquan Zhang; Jiajun Guo; Yuanwei Xu; Ke Wan; Heng Xu; Yuchi Han; Georgios V Gkoutos; Yucheng Chen
Published in: Precision Clinical Medicine, 2025, ISSN 2516-1571
Publisher: Oxford University Press
DOI: 10.1093/PCMEDI/PBAF019

Journal of Translational Medicine

Author(s): Animesh Acharjee; Susanne N. Wijesinghe; Dominic Russ; Georgios Gkoutos; Simon W. Jones
Published in: Journal of Translational Medicine, 2024, ISSN 1479-5876
Publisher: BioMed Central
DOI: 10.1186/S12967-024-05414-1

Anticoagulation in device-detected atrial fibrillation with or without vascular disease: a combined analysis of the NOAH-AFNET 6 and ARTESiA trials

Author(s): Schnabel, Renate; Mazuecos, Juan Benezet; Becher, Nina; F Mcintyre, William; Fierenz, Alexander; Lee, Shun Fu; Goette, Andreas; Atar, Dan; Bertaglia, Emanuele; P Benz, Alexander; Chlouverakis, Gregory; H Birnie, David; Dichtl, Wolfgang; Blomström-Lundqvist, Carina; Camm, A; W Erath, Julia; Simantirakis, Emmanuel; Kutyifa, Valentina; Lip, Gregory Y.H.; Mabo, Philippe; Marijon, Eloi; Rivard, Léna; Schotten, Ulrich; Alings, Marco; Sehner, Susanne; Toennis, Tobias; Linde, Cecilia; Vardas, Panos; Granger, Christopher; Zapf, Antonia; Lopes, Renato; Healey, Jeff S; Kirchhof, Paulus
Published in: European Heart Journal, 2024, ISSN 1522-9645
Publisher: Oxford University Press
DOI: 10.1093/EURHEARTJ/EHAE596

BMC Medical Informatics and Decision Making

Author(s): Samuel Cusworth; Georgios V. Gkoutos; Animesh Acharjee
Published in: BMC Medical Informatics and Decision Making, 2024, ISSN 1472-6947
Publisher: BioMed Central Ltd.
DOI: 10.1186/S12911-024-02487-2

Taurine as a biomarker for aging: A new avenue for translational research

Author(s): Animesh Acharjee
Published in: Advances in Biomarker Sciences and Technology, 2023, ISSN 2543-1064
Publisher: Elsevier B.V.
DOI: 10.1016/J.ABST.2023.10.002

Translational research and key aspects to make it successful

Author(s): Animesh Acharjee
Published in: Translational Medicine Communications, 2023, ISSN 2396-832X
Publisher: BioMed Central
DOI: 10.1186/S41231-023-00153-9

Editorial: Integrative multi-modal, multi-omics analytics for the better understanding of metabolic diseases

Author(s): Animesh Acharjee; Animesh Acharjee; Animesh Acharjee; Animesh Acharjee; Prasoon Agarwal; Georgios V. Gkoutos; Georgios V. Gkoutos; Georgios V. Gkoutos; Georgios V. Gkoutos; Georgios V. Gkoutos
Published in: Frontiers in Endocrinology, 2023, ISSN 2297-055X
Publisher: Frontiers Media
DOI: 10.3389/FENDO.2023.1266557

Scientific Reports

Author(s): Aziz, Furqan; Slater, Luke T.; Bravo-Merodio, Laura; Acharjee, Animesh; Gkoutos, Georgios V.
Published in: Scientific Reports, 2023, ISSN 2045-2322
Publisher: Nature Portfolio
DOI: 10.1038/S41598-023-41476-9

Analysis of translesion polymerases in colorectal cancer cells following cetuximab treatment: A network perspective

Author(s): Anubrata Das; Georgios V. Gkoutos; Animesh Acharjee
Published in: Cancer Medicine, 2024, ISSN 2045-7634
Publisher: John Wiley & Sons Ltd
DOI: 10.1002/CAM4.6945

Talking about diseases; developing a model of patient and public-prioritised disease phenotypes

Author(s): Karin Slater; Paul N. Schofield; James Wright; Paul Clift; Anushka Irani; William Bradlow; Furqan Aziz; Georgios V. Gkoutos
Published in: npj Digital Medicine, Issue 7, 263, 2024, ISSN 2398-6352
Publisher: Nature Portfolio
DOI: 10.1038/S41746-024-01257-8

Biomarker-based prediction of sinus rhythm in atrial fibrillation patients: the EAST-AFNET 4 biomolecule study

Author(s): Larissa Fabritz; Christoph Al-Taie; Katrin Borof; Günter Breithardt; A John Camm; Harry J G M Crijns; Victor Roth Cardoso; Winnie Chua; Silke van Elferen; Lars Eckardt; Georgios Gkoutos; Andreas Goette; Eduard Guasch; Stéphane Hatem; Andreas Metzner; Lluís Mont; Vaishnavi Ameya Murukutla; Julius Obergassel; Andreas Rillig; Moritz F Sinner; Renate B Schnabel; Ulrich Schotten; Laura C Sommerfeld; Ursula-Henrike Wienhues-Thelen; Antonia Zapf; Tanja Zeller; Paulus Kirchhof
Published in: European Heart Journal, 2024, ISSN 1522-9645
Publisher: Oxford University Press
DOI: 10.1093/EURHEARTJ/EHAE611

Diffused responsibilities in technology-driven health research: The case of artificial intelligence systems in decentralized clinical trials

Author(s): Sam H.A. Muller, Tessa I. van Rijssel, Ghislaine J.M.W. van Thiel
Published in: Drug Discovery Today, Issue 30, 2025, ISSN 1359-6446
Publisher: Elsevier BV
DOI: 10.1016/j.drudis.2025.104309

The budget impact of implementing atrial fibrillation-screening in European countries

Author(s): Michaela Eklund; Lars Bernfort; Kajsa Appelberg; Daniel Engler; Renate B Schnabel; Carlos Martinez; Christopher Wallenhorst; Giuseppe Boriani; Claire M Buckley; Søren Zöga Diederichsen; Jesper Hastrup Svendsen; Joan Montaner; Tatjana Potpara; Lars-Åke Levin; Johan Lyth
Published in: European Heart Journal Supplements, 2024, ISSN 1554-2815
Publisher: Oxford University Press
DOI: 10.1093/EURHEARTJSUPP/SUAE076

Other (1)

Modulation of antihypertensive drug effectiveness by dietary consumption: a scoping review

Author(s): Miah, Bristi; Knikman, Jonathan; van der Schouw, Yvonne; Geleijnse, Marianne
Published in: 2024
Publisher: Not applicable
DOI: 10.5281/ZENODO.10664848