Personalised pharmacometabolomic optimisation of treatment for hypertension

Informazioni relative al progetto

Hypermarker

ID dell’accordo di sovvenzione: 101095480

DOI

10.3030/101095480

Data della firma CE 8 Dicembre 2022

Data di avvio 1 Gennaio 2023

Data di completamento 31 Dicembre 2026

Finanziato da

• Health

Costo totale

€ 8 046 250,00

Contributo UE

€ 8 046 250,00

Coordinato da

UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Data Management Plan (2)

Data management plan
Updated Data management plan

Update to D1.1 Data management plan

Documents, reports (7)

Validation report of extended metabolomics/exposomics platform
Report on the economic burden of chronic, uncontrolled hypertension in Europe
Completed study initiation package with PPIE input
Report on the best identified prediction method based on the accuracy
Development of the causal map between selected markers
Plan for dissemination and communication activities
Report on return of results policies for large-scale pharmacometabolomics research

Report on return of results policies for large-scale pharmacometabolomics research

Websites, patent fillings, videos etc. (1)

Project website

Pubblicazioni

Peer reviewed articles (20)

Data source and utilization of artificial intelligence technologies in vascular surgery—a scoping review

Autori: Katarzyna Powezka; Katarzyna Powezka; Katarzyna Powezka; Karin Slater; David Brind; Michael Wall; Michael Wall; Georgios Gkoutos; Maciej Juszczak; Maciej Juszczak
Pubblicato in: Frontiers in Cardiovascular Medicine, 2025, ISSN 2297-055X
Editore: Frontiers Media
DOI: 10.3389/FCVM.2025.1497822

Blood-based cardiometabolic phenotypes in atrial fibrillation and their associated risk: EAST-AFNET 4 biomolecule study

Autori: Larissa Fabritz; Winnie Chua; Victor R Cardoso; Christoph Al-Taie; Katrin Borof; Anna Suling; Linda Krause; Shinwan Kany; Christina Magnussen; Karl Wegscheider; Guenter Breithardt; Harry J G M Crijns; A John Camm; George Gkoutos; Patrick T Ellinor; Andreas Goette; Ulrich Schotten; Ursula-Henrike Wienhues-Thelen; Tanja Zeller; Renate B Schnabel; Antonia Zapf; Paulus Kirchhof
Pubblicato in: Cardiovascular Research, 2024, ISSN 1755-3245
Editore: Oxford University Press
DOI: 10.1093/CVR/CVAE067

Towards responsible surveillance in preventive health data-AI research

Autori: Sam H. A. Muller, Johannes J. M. van Delden, Ghislaine J. M. W. van Thiel, null null
Pubblicato in: PLOS Digital Health, Numero 4, 2025, ISSN 2767-3170
Editore: Public Library of Science (PLoS)
DOI: 10.1371/JOURNAL.PDIG.0001146

Explainable AI-prioritized plasma and fecal metabolites in inflammatory bowel disease and their dietary associations

Autori: Serena Onwuka; Laura Bravo-Merodio; Georgios V. Gkoutos; Animesh Acharjee
Pubblicato in: iScience, 2024, ISSN 2589-0042
Editore: Cell Press
DOI: 10.1016/J.ISCI.2024.110298

A computational framework for inferring species dynamics and interactions with applications in microbiota ecology

Autori: Xu, Yuanwei; Gkoutos, Georgios V.
Pubblicato in: npj Systems Biology and Applications, 2025, ISSN 2056-7189
Editore: Nature Portfolio
DOI: 10.1038/S41540-025-00568-0

High hypoxia status in pancreatic cancer is associated with multiple hallmarks of an immunosuppressive tumor microenvironment

Autori: Hassan Sadozai; Animesh Acharjee; Hateem Z. Kayani; Thomas Gruber; Reginald M. Gorczynski; Bernard Burke
Pubblicato in: Frontiers in Immunology, 2024, ISSN 2297-055X
Editore: Frontiers Media
DOI: 10.3389/FIMMU.2024.1360629

Genetic architecture of hypertrophic cardiomyopathy in individuals of Chinese and United Kingdom ancestry

Autori: Jie Wang; Dominic Russ; Yongsan Yang; Lutong Pu; Mengdi Yu; Jinquan Zhang; Jiajun Guo; Yuanwei Xu; Ke Wan; Heng Xu; Yuchi Han; Georgios V Gkoutos; Yucheng Chen
Pubblicato in: Precision Clinical Medicine, 2025, ISSN 2516-1571
Editore: Oxford University Press
DOI: 10.1093/PCMEDI/PBAF019

Journal of Translational Medicine

Autori: Animesh Acharjee; Susanne N. Wijesinghe; Dominic Russ; Georgios Gkoutos; Simon W. Jones
Pubblicato in: Journal of Translational Medicine, 2024, ISSN 1479-5876
Editore: BioMed Central
DOI: 10.1186/S12967-024-05414-1

Anticoagulation in device-detected atrial fibrillation with or without vascular disease: a combined analysis of the NOAH-AFNET 6 and ARTESiA trials

Autori: Schnabel, Renate; Mazuecos, Juan Benezet; Becher, Nina; F Mcintyre, William; Fierenz, Alexander; Lee, Shun Fu; Goette, Andreas; Atar, Dan; Bertaglia, Emanuele; P Benz, Alexander; Chlouverakis, Gregory; H Birnie, David; Dichtl, Wolfgang; Blomström-Lundqvist, Carina; Camm, A; W Erath, Julia; Simantirakis, Emmanuel; Kutyifa, Valentina; Lip, Gregory Y.H.; Mabo, Philippe; Marijon, Eloi; Rivard, Léna; Schotten, Ulrich; Alings, Marco; Sehner, Susanne; Toennis, Tobias; Linde, Cecilia; Vardas, Panos; Granger, Christopher; Zapf, Antonia; Lopes, Renato; Healey, Jeff S; Kirchhof, Paulus
Pubblicato in: European Heart Journal, 2024, ISSN 1522-9645
Editore: Oxford University Press
DOI: 10.1093/EURHEARTJ/EHAE596

BMC Medical Informatics and Decision Making

Autori: Samuel Cusworth; Georgios V. Gkoutos; Animesh Acharjee
Pubblicato in: BMC Medical Informatics and Decision Making, 2024, ISSN 1472-6947
Editore: BioMed Central Ltd.
DOI: 10.1186/S12911-024-02487-2

Taurine as a biomarker for aging: A new avenue for translational research

Autori: Animesh Acharjee
Pubblicato in: Advances in Biomarker Sciences and Technology, 2023, ISSN 2543-1064
Editore: Elsevier B.V.
DOI: 10.1016/J.ABST.2023.10.002

Translational research and key aspects to make it successful

Autori: Animesh Acharjee
Pubblicato in: Translational Medicine Communications, 2023, ISSN 2396-832X
Editore: BioMed Central
DOI: 10.1186/S41231-023-00153-9

Editorial: Integrative multi-modal, multi-omics analytics for the better understanding of metabolic diseases

Autori: Animesh Acharjee; Animesh Acharjee; Animesh Acharjee; Animesh Acharjee; Prasoon Agarwal; Georgios V. Gkoutos; Georgios V. Gkoutos; Georgios V. Gkoutos; Georgios V. Gkoutos; Georgios V. Gkoutos
Pubblicato in: Frontiers in Endocrinology, 2023, ISSN 2297-055X
Editore: Frontiers Media
DOI: 10.3389/FENDO.2023.1266557

Scientific Reports

Autori: Aziz, Furqan; Slater, Luke T.; Bravo-Merodio, Laura; Acharjee, Animesh; Gkoutos, Georgios V.
Pubblicato in: Scientific Reports, 2023, ISSN 2045-2322
Editore: Nature Portfolio
DOI: 10.1038/S41598-023-41476-9

Analysis of translesion polymerases in colorectal cancer cells following cetuximab treatment: A network perspective

Autori: Anubrata Das; Georgios V. Gkoutos; Animesh Acharjee
Pubblicato in: Cancer Medicine, 2024, ISSN 2045-7634
Editore: John Wiley & Sons Ltd
DOI: 10.1002/CAM4.6945

Transforming clinical decisions with artificial intelligence: the HYPERMARKER project

Autori: Dipak Kotecha, Thomas Hankemeier, Diederick E Grobbee
Pubblicato in: European Heart Journal, 2026, ISSN 0195-668X
Editore: Oxford University Press (OUP)
DOI: 10.1093/EURHEARTJ/EHAG165

Talking about diseases; developing a model of patient and public-prioritised disease phenotypes

Autori: Karin Slater; Paul N. Schofield; James Wright; Paul Clift; Anushka Irani; William Bradlow; Furqan Aziz; Georgios V. Gkoutos
Pubblicato in: npj Digital Medicine, Numero 7, 263, 2024, ISSN 2398-6352
Editore: Nature Portfolio
DOI: 10.1038/S41746-024-01257-8

Biomarker-based prediction of sinus rhythm in atrial fibrillation patients: the EAST-AFNET 4 biomolecule study

Autori: Larissa Fabritz; Christoph Al-Taie; Katrin Borof; Günter Breithardt; A John Camm; Harry J G M Crijns; Victor Roth Cardoso; Winnie Chua; Silke van Elferen; Lars Eckardt; Georgios Gkoutos; Andreas Goette; Eduard Guasch; Stéphane Hatem; Andreas Metzner; Lluís Mont; Vaishnavi Ameya Murukutla; Julius Obergassel; Andreas Rillig; Moritz F Sinner; Renate B Schnabel; Ulrich Schotten; Laura C Sommerfeld; Ursula-Henrike Wienhues-Thelen; Antonia Zapf; Tanja Zeller; Paulus Kirchhof
Pubblicato in: European Heart Journal, 2024, ISSN 1522-9645
Editore: Oxford University Press
DOI: 10.1093/EURHEARTJ/EHAE611

Diffused responsibilities in technology-driven health research: The case of artificial intelligence systems in decentralized clinical trials

Autori: Sam H.A. Muller, Tessa I. van Rijssel, Ghislaine J.M.W. van Thiel
Pubblicato in: Drug Discovery Today, Numero 30, 2025, ISSN 1359-6446
Editore: Elsevier BV
DOI: 10.1016/j.drudis.2025.104309

The budget impact of implementing atrial fibrillation-screening in European countries

Autori: Michaela Eklund; Lars Bernfort; Kajsa Appelberg; Daniel Engler; Renate B Schnabel; Carlos Martinez; Christopher Wallenhorst; Giuseppe Boriani; Claire M Buckley; Søren Zöga Diederichsen; Jesper Hastrup Svendsen; Joan Montaner; Tatjana Potpara; Lars-Åke Levin; Johan Lyth
Pubblicato in: European Heart Journal Supplements, 2024, ISSN 1554-2815
Editore: Oxford University Press
DOI: 10.1093/EURHEARTJSUPP/SUAE076

Other (1)

Modulation of antihypertensive drug effectiveness by dietary consumption: a scoping review

Autori: Miah, Bristi; Knikman, Jonathan; van der Schouw, Yvonne; Geleijnse, Marianne
Pubblicato in: 2024
Editore: Not applicable
DOI: 10.5281/ZENODO.10664848