Personalised pharmacometabolomic optimisation of treatment for hypertension

Informations projet

Hypermarker

N° de convention de subvention: 101095480

DOI

10.3030/101095480

Date de signature de la CE 8 Decembre 2022

Date de début 1 Janvier 2023

Date de fin 31 Decembre 2026

Financé au titre de

• Health

Coût total

€ 8 046 250,00

Contribution de l’UE

€ 8 046 250,00

Coordonné par

UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Data Management Plan (1)

Data management plan

Documents, reports (2)

Validation report of extended metabolomics/exposomics platform
Plan for dissemination and communication activities

Websites, patent fillings, videos etc. (1)

Project website

Publications

Peer reviewed articles (19)

Data source and utilization of artificial intelligence technologies in vascular surgery—a scoping review

Auteurs: Katarzyna Powezka; Katarzyna Powezka; Katarzyna Powezka; Karin Slater; David Brind; Michael Wall; Michael Wall; Georgios Gkoutos; Maciej Juszczak; Maciej Juszczak
Publié dans: Frontiers in Cardiovascular Medicine, 2025, ISSN 2297-055X
Éditeur: Frontiers Media
DOI: 10.3389/FCVM.2025.1497822

Blood-based cardiometabolic phenotypes in atrial fibrillation and their associated risk: EAST-AFNET 4 biomolecule study

Auteurs: Larissa Fabritz; Winnie Chua; Victor R Cardoso; Christoph Al-Taie; Katrin Borof; Anna Suling; Linda Krause; Shinwan Kany; Christina Magnussen; Karl Wegscheider; Guenter Breithardt; Harry J G M Crijns; A John Camm; George Gkoutos; Patrick T Ellinor; Andreas Goette; Ulrich Schotten; Ursula-Henrike Wienhues-Thelen; Tanja Zeller; Renate B Schnabel; Antonia Zapf; Paulus Kirchhof
Publié dans: Cardiovascular Research, 2024, ISSN 1755-3245
Éditeur: Oxford University Press
DOI: 10.1093/CVR/CVAE067

Towards responsible surveillance in preventive health data-AI research

Auteurs: Sam H. A. Muller, Johannes J. M. van Delden, Ghislaine J. M. W. van Thiel, null null
Publié dans: PLOS Digital Health, Numéro 4, 2025, ISSN 2767-3170
Éditeur: Public Library of Science (PLoS)
DOI: 10.1371/JOURNAL.PDIG.0001146

Explainable AI-prioritized plasma and fecal metabolites in inflammatory bowel disease and their dietary associations

Auteurs: Serena Onwuka; Laura Bravo-Merodio; Georgios V. Gkoutos; Animesh Acharjee
Publié dans: iScience, 2024, ISSN 2589-0042
Éditeur: Cell Press
DOI: 10.1016/J.ISCI.2024.110298

A computational framework for inferring species dynamics and interactions with applications in microbiota ecology

Auteurs: Xu, Yuanwei; Gkoutos, Georgios V.
Publié dans: npj Systems Biology and Applications, 2025, ISSN 2056-7189
Éditeur: Nature Portfolio
DOI: 10.1038/S41540-025-00568-0

High hypoxia status in pancreatic cancer is associated with multiple hallmarks of an immunosuppressive tumor microenvironment

Auteurs: Hassan Sadozai; Animesh Acharjee; Hateem Z. Kayani; Thomas Gruber; Reginald M. Gorczynski; Bernard Burke
Publié dans: Frontiers in Immunology, 2024, ISSN 2297-055X
Éditeur: Frontiers Media
DOI: 10.3389/FIMMU.2024.1360629

Genetic architecture of hypertrophic cardiomyopathy in individuals of Chinese and United Kingdom ancestry

Auteurs: Jie Wang; Dominic Russ; Yongsan Yang; Lutong Pu; Mengdi Yu; Jinquan Zhang; Jiajun Guo; Yuanwei Xu; Ke Wan; Heng Xu; Yuchi Han; Georgios V Gkoutos; Yucheng Chen
Publié dans: Precision Clinical Medicine, 2025, ISSN 2516-1571
Éditeur: Oxford University Press
DOI: 10.1093/PCMEDI/PBAF019

Journal of Translational Medicine

Auteurs: Animesh Acharjee; Susanne N. Wijesinghe; Dominic Russ; Georgios Gkoutos; Simon W. Jones
Publié dans: Journal of Translational Medicine, 2024, ISSN 1479-5876
Éditeur: BioMed Central
DOI: 10.1186/S12967-024-05414-1

Anticoagulation in device-detected atrial fibrillation with or without vascular disease: a combined analysis of the NOAH-AFNET 6 and ARTESiA trials

Auteurs: Schnabel, Renate; Mazuecos, Juan Benezet; Becher, Nina; F Mcintyre, William; Fierenz, Alexander; Lee, Shun Fu; Goette, Andreas; Atar, Dan; Bertaglia, Emanuele; P Benz, Alexander; Chlouverakis, Gregory; H Birnie, David; Dichtl, Wolfgang; Blomström-Lundqvist, Carina; Camm, A; W Erath, Julia; Simantirakis, Emmanuel; Kutyifa, Valentina; Lip, Gregory Y.H.; Mabo, Philippe; Marijon, Eloi; Rivard, Léna; Schotten, Ulrich; Alings, Marco; Sehner, Susanne; Toennis, Tobias; Linde, Cecilia; Vardas, Panos; Granger, Christopher; Zapf, Antonia; Lopes, Renato; Healey, Jeff S; Kirchhof, Paulus
Publié dans: European Heart Journal, 2024, ISSN 1522-9645
Éditeur: Oxford University Press
DOI: 10.1093/EURHEARTJ/EHAE596

BMC Medical Informatics and Decision Making

Auteurs: Samuel Cusworth; Georgios V. Gkoutos; Animesh Acharjee
Publié dans: BMC Medical Informatics and Decision Making, 2024, ISSN 1472-6947
Éditeur: BioMed Central Ltd.
DOI: 10.1186/S12911-024-02487-2

Taurine as a biomarker for aging: A new avenue for translational research

Auteurs: Animesh Acharjee
Publié dans: Advances in Biomarker Sciences and Technology, 2023, ISSN 2543-1064
Éditeur: Elsevier B.V.
DOI: 10.1016/J.ABST.2023.10.002

Translational research and key aspects to make it successful

Auteurs: Animesh Acharjee
Publié dans: Translational Medicine Communications, 2023, ISSN 2396-832X
Éditeur: BioMed Central
DOI: 10.1186/S41231-023-00153-9

Editorial: Integrative multi-modal, multi-omics analytics for the better understanding of metabolic diseases

Auteurs: Animesh Acharjee; Animesh Acharjee; Animesh Acharjee; Animesh Acharjee; Prasoon Agarwal; Georgios V. Gkoutos; Georgios V. Gkoutos; Georgios V. Gkoutos; Georgios V. Gkoutos; Georgios V. Gkoutos
Publié dans: Frontiers in Endocrinology, 2023, ISSN 2297-055X
Éditeur: Frontiers Media
DOI: 10.3389/FENDO.2023.1266557

Scientific Reports

Auteurs: Aziz, Furqan; Slater, Luke T.; Bravo-Merodio, Laura; Acharjee, Animesh; Gkoutos, Georgios V.
Publié dans: Scientific Reports, 2023, ISSN 2045-2322
Éditeur: Nature Portfolio
DOI: 10.1038/S41598-023-41476-9

Analysis of translesion polymerases in colorectal cancer cells following cetuximab treatment: A network perspective

Auteurs: Anubrata Das; Georgios V. Gkoutos; Animesh Acharjee
Publié dans: Cancer Medicine, 2024, ISSN 2045-7634
Éditeur: John Wiley & Sons Ltd
DOI: 10.1002/CAM4.6945

Talking about diseases; developing a model of patient and public-prioritised disease phenotypes

Auteurs: Karin Slater; Paul N. Schofield; James Wright; Paul Clift; Anushka Irani; William Bradlow; Furqan Aziz; Georgios V. Gkoutos
Publié dans: npj Digital Medicine, Numéro 7, 263, 2024, ISSN 2398-6352
Éditeur: Nature Portfolio
DOI: 10.1038/S41746-024-01257-8

Biomarker-based prediction of sinus rhythm in atrial fibrillation patients: the EAST-AFNET 4 biomolecule study

Auteurs: Larissa Fabritz; Christoph Al-Taie; Katrin Borof; Günter Breithardt; A John Camm; Harry J G M Crijns; Victor Roth Cardoso; Winnie Chua; Silke van Elferen; Lars Eckardt; Georgios Gkoutos; Andreas Goette; Eduard Guasch; Stéphane Hatem; Andreas Metzner; Lluís Mont; Vaishnavi Ameya Murukutla; Julius Obergassel; Andreas Rillig; Moritz F Sinner; Renate B Schnabel; Ulrich Schotten; Laura C Sommerfeld; Ursula-Henrike Wienhues-Thelen; Antonia Zapf; Tanja Zeller; Paulus Kirchhof
Publié dans: European Heart Journal, 2024, ISSN 1522-9645
Éditeur: Oxford University Press
DOI: 10.1093/EURHEARTJ/EHAE611

Diffused responsibilities in technology-driven health research: The case of artificial intelligence systems in decentralized clinical trials

Auteurs: Sam H.A. Muller, Tessa I. van Rijssel, Ghislaine J.M.W. van Thiel
Publié dans: Drug Discovery Today, Numéro 30, 2025, ISSN 1359-6446
Éditeur: Elsevier BV
DOI: 10.1016/j.drudis.2025.104309

The budget impact of implementing atrial fibrillation-screening in European countries

Auteurs: Michaela Eklund; Lars Bernfort; Kajsa Appelberg; Daniel Engler; Renate B Schnabel; Carlos Martinez; Christopher Wallenhorst; Giuseppe Boriani; Claire M Buckley; Søren Zöga Diederichsen; Jesper Hastrup Svendsen; Joan Montaner; Tatjana Potpara; Lars-Åke Levin; Johan Lyth
Publié dans: European Heart Journal Supplements, 2024, ISSN 1554-2815
Éditeur: Oxford University Press
DOI: 10.1093/EURHEARTJSUPP/SUAE076

Other (1)

Modulation of antihypertensive drug effectiveness by dietary consumption: a scoping review

Auteurs: Miah, Bristi; Knikman, Jonathan; van der Schouw, Yvonne; Geleijnse, Marianne
Publié dans: 2024
Éditeur: Not applicable
DOI: 10.5281/ZENODO.10664848