Personalised pharmacometabolomic optimisation of treatment for hypertension

Información del proyecto

Hypermarker

Identificador del acuerdo de subvención: 101095480

DOI

10.3030/101095480

Fecha de la firma de la CE 8 Diciembre 2022

Fecha de inicio 1 Enero 2023

Fecha de finalización 31 Diciembre 2026

Financiado con arreglo a

• Health

Coste total

€ 8 046 250,00

Aportación de la UE

€ 8 046 250,00

Coordinado por

UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Data Management Plan (2)

Data management plan
Updated Data management plan

Update to D1.1 Data management plan

Documents, reports (7)

Validation report of extended metabolomics/exposomics platform
Report on the economic burden of chronic, uncontrolled hypertension in Europe
Completed study initiation package with PPIE input
Report on the best identified prediction method based on the accuracy
Development of the causal map between selected markers
Plan for dissemination and communication activities
Report on return of results policies for large-scale pharmacometabolomics research

Report on return of results policies for large-scale pharmacometabolomics research

Websites, patent fillings, videos etc. (1)

Project website

Publicaciones

Peer reviewed articles (20)

Data source and utilization of artificial intelligence technologies in vascular surgery—a scoping review

Autores: Katarzyna Powezka; Katarzyna Powezka; Katarzyna Powezka; Karin Slater; David Brind; Michael Wall; Michael Wall; Georgios Gkoutos; Maciej Juszczak; Maciej Juszczak
Publicado en: Frontiers in Cardiovascular Medicine, 2025, ISSN 2297-055X
Editor: Frontiers Media
DOI: 10.3389/FCVM.2025.1497822

Blood-based cardiometabolic phenotypes in atrial fibrillation and their associated risk: EAST-AFNET 4 biomolecule study

Autores: Larissa Fabritz; Winnie Chua; Victor R Cardoso; Christoph Al-Taie; Katrin Borof; Anna Suling; Linda Krause; Shinwan Kany; Christina Magnussen; Karl Wegscheider; Guenter Breithardt; Harry J G M Crijns; A John Camm; George Gkoutos; Patrick T Ellinor; Andreas Goette; Ulrich Schotten; Ursula-Henrike Wienhues-Thelen; Tanja Zeller; Renate B Schnabel; Antonia Zapf; Paulus Kirchhof
Publicado en: Cardiovascular Research, 2024, ISSN 1755-3245
Editor: Oxford University Press
DOI: 10.1093/CVR/CVAE067

Towards responsible surveillance in preventive health data-AI research

Autores: Sam H. A. Muller, Johannes J. M. van Delden, Ghislaine J. M. W. van Thiel, null null
Publicado en: PLOS Digital Health, Edición 4, 2025, ISSN 2767-3170
Editor: Public Library of Science (PLoS)
DOI: 10.1371/JOURNAL.PDIG.0001146

Explainable AI-prioritized plasma and fecal metabolites in inflammatory bowel disease and their dietary associations

Autores: Serena Onwuka; Laura Bravo-Merodio; Georgios V. Gkoutos; Animesh Acharjee
Publicado en: iScience, 2024, ISSN 2589-0042
Editor: Cell Press
DOI: 10.1016/J.ISCI.2024.110298

A computational framework for inferring species dynamics and interactions with applications in microbiota ecology

Autores: Xu, Yuanwei; Gkoutos, Georgios V.
Publicado en: npj Systems Biology and Applications, 2025, ISSN 2056-7189
Editor: Nature Portfolio
DOI: 10.1038/S41540-025-00568-0

High hypoxia status in pancreatic cancer is associated with multiple hallmarks of an immunosuppressive tumor microenvironment

Autores: Hassan Sadozai; Animesh Acharjee; Hateem Z. Kayani; Thomas Gruber; Reginald M. Gorczynski; Bernard Burke
Publicado en: Frontiers in Immunology, 2024, ISSN 2297-055X
Editor: Frontiers Media
DOI: 10.3389/FIMMU.2024.1360629

Genetic architecture of hypertrophic cardiomyopathy in individuals of Chinese and United Kingdom ancestry

Autores: Jie Wang; Dominic Russ; Yongsan Yang; Lutong Pu; Mengdi Yu; Jinquan Zhang; Jiajun Guo; Yuanwei Xu; Ke Wan; Heng Xu; Yuchi Han; Georgios V Gkoutos; Yucheng Chen
Publicado en: Precision Clinical Medicine, 2025, ISSN 2516-1571
Editor: Oxford University Press
DOI: 10.1093/PCMEDI/PBAF019

Journal of Translational Medicine

Autores: Animesh Acharjee; Susanne N. Wijesinghe; Dominic Russ; Georgios Gkoutos; Simon W. Jones
Publicado en: Journal of Translational Medicine, 2024, ISSN 1479-5876
Editor: BioMed Central
DOI: 10.1186/S12967-024-05414-1

Anticoagulation in device-detected atrial fibrillation with or without vascular disease: a combined analysis of the NOAH-AFNET 6 and ARTESiA trials

Autores: Schnabel, Renate; Mazuecos, Juan Benezet; Becher, Nina; F Mcintyre, William; Fierenz, Alexander; Lee, Shun Fu; Goette, Andreas; Atar, Dan; Bertaglia, Emanuele; P Benz, Alexander; Chlouverakis, Gregory; H Birnie, David; Dichtl, Wolfgang; Blomström-Lundqvist, Carina; Camm, A; W Erath, Julia; Simantirakis, Emmanuel; Kutyifa, Valentina; Lip, Gregory Y.H.; Mabo, Philippe; Marijon, Eloi; Rivard, Léna; Schotten, Ulrich; Alings, Marco; Sehner, Susanne; Toennis, Tobias; Linde, Cecilia; Vardas, Panos; Granger, Christopher; Zapf, Antonia; Lopes, Renato; Healey, Jeff S; Kirchhof, Paulus
Publicado en: European Heart Journal, 2024, ISSN 1522-9645
Editor: Oxford University Press
DOI: 10.1093/EURHEARTJ/EHAE596

BMC Medical Informatics and Decision Making

Autores: Samuel Cusworth; Georgios V. Gkoutos; Animesh Acharjee
Publicado en: BMC Medical Informatics and Decision Making, 2024, ISSN 1472-6947
Editor: BioMed Central Ltd.
DOI: 10.1186/S12911-024-02487-2

Taurine as a biomarker for aging: A new avenue for translational research

Autores: Animesh Acharjee
Publicado en: Advances in Biomarker Sciences and Technology, 2023, ISSN 2543-1064
Editor: Elsevier B.V.
DOI: 10.1016/J.ABST.2023.10.002

Translational research and key aspects to make it successful

Autores: Animesh Acharjee
Publicado en: Translational Medicine Communications, 2023, ISSN 2396-832X
Editor: BioMed Central
DOI: 10.1186/S41231-023-00153-9

Editorial: Integrative multi-modal, multi-omics analytics for the better understanding of metabolic diseases

Autores: Animesh Acharjee; Animesh Acharjee; Animesh Acharjee; Animesh Acharjee; Prasoon Agarwal; Georgios V. Gkoutos; Georgios V. Gkoutos; Georgios V. Gkoutos; Georgios V. Gkoutos; Georgios V. Gkoutos
Publicado en: Frontiers in Endocrinology, 2023, ISSN 2297-055X
Editor: Frontiers Media
DOI: 10.3389/FENDO.2023.1266557

Scientific Reports

Autores: Aziz, Furqan; Slater, Luke T.; Bravo-Merodio, Laura; Acharjee, Animesh; Gkoutos, Georgios V.
Publicado en: Scientific Reports, 2023, ISSN 2045-2322
Editor: Nature Portfolio
DOI: 10.1038/S41598-023-41476-9

Analysis of translesion polymerases in colorectal cancer cells following cetuximab treatment: A network perspective

Autores: Anubrata Das; Georgios V. Gkoutos; Animesh Acharjee
Publicado en: Cancer Medicine, 2024, ISSN 2045-7634
Editor: John Wiley & Sons Ltd
DOI: 10.1002/CAM4.6945

Transforming clinical decisions with artificial intelligence: the HYPERMARKER project

Autores: Dipak Kotecha, Thomas Hankemeier, Diederick E Grobbee
Publicado en: European Heart Journal, 2026, ISSN 0195-668X
Editor: Oxford University Press (OUP)
DOI: 10.1093/EURHEARTJ/EHAG165

Talking about diseases; developing a model of patient and public-prioritised disease phenotypes

Autores: Karin Slater; Paul N. Schofield; James Wright; Paul Clift; Anushka Irani; William Bradlow; Furqan Aziz; Georgios V. Gkoutos
Publicado en: npj Digital Medicine, Edición 7, 263, 2024, ISSN 2398-6352
Editor: Nature Portfolio
DOI: 10.1038/S41746-024-01257-8

Biomarker-based prediction of sinus rhythm in atrial fibrillation patients: the EAST-AFNET 4 biomolecule study

Autores: Larissa Fabritz; Christoph Al-Taie; Katrin Borof; Günter Breithardt; A John Camm; Harry J G M Crijns; Victor Roth Cardoso; Winnie Chua; Silke van Elferen; Lars Eckardt; Georgios Gkoutos; Andreas Goette; Eduard Guasch; Stéphane Hatem; Andreas Metzner; Lluís Mont; Vaishnavi Ameya Murukutla; Julius Obergassel; Andreas Rillig; Moritz F Sinner; Renate B Schnabel; Ulrich Schotten; Laura C Sommerfeld; Ursula-Henrike Wienhues-Thelen; Antonia Zapf; Tanja Zeller; Paulus Kirchhof
Publicado en: European Heart Journal, 2024, ISSN 1522-9645
Editor: Oxford University Press
DOI: 10.1093/EURHEARTJ/EHAE611

Diffused responsibilities in technology-driven health research: The case of artificial intelligence systems in decentralized clinical trials

Autores: Sam H.A. Muller, Tessa I. van Rijssel, Ghislaine J.M.W. van Thiel
Publicado en: Drug Discovery Today, Edición 30, 2025, ISSN 1359-6446
Editor: Elsevier BV
DOI: 10.1016/j.drudis.2025.104309

The budget impact of implementing atrial fibrillation-screening in European countries

Autores: Michaela Eklund; Lars Bernfort; Kajsa Appelberg; Daniel Engler; Renate B Schnabel; Carlos Martinez; Christopher Wallenhorst; Giuseppe Boriani; Claire M Buckley; Søren Zöga Diederichsen; Jesper Hastrup Svendsen; Joan Montaner; Tatjana Potpara; Lars-Åke Levin; Johan Lyth
Publicado en: European Heart Journal Supplements, 2024, ISSN 1554-2815
Editor: Oxford University Press
DOI: 10.1093/EURHEARTJSUPP/SUAE076

Other (1)

Modulation of antihypertensive drug effectiveness by dietary consumption: a scoping review

Autores: Miah, Bristi; Knikman, Jonathan; van der Schouw, Yvonne; Geleijnse, Marianne
Publicado en: 2024
Editor: Not applicable
DOI: 10.5281/ZENODO.10664848