Project description
Biomarkers for non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) is a complex disease associated with fat accumulation and inflammation in the liver. NAFLD is difficult to diagnose and treat because the underlying molecular mechanisms remain elusive. The EU-funded halt-RONIN project aims to investigate how healthy patients transition to NAFLD. The consortium will develop in vitro and in vivo models and, alongside patient clinical data, it will discover new biomarkers and specific molecular targets. Results are expected to assist in the diagnosis of NAFLD, in the development of disease-modifying intervention as well as in prevention guidelines.
Objective
Non-alcoholic fatty liver disease (NAFLD) is a multifactorial chronic inflammatory disease that is prevalent in 1 of 4 individuals with a significant personal, socioeconomic and healthcare burden, especially at the later, more severe inflammatory stage of disease - non-alcoholic steatohepatitis (NASH). Despite the severe negative impact of the disease on society, NAFLD remains difficult to diagnose and treat. Additionally, the molecular mechanisms underlying the transition from health to fatty liver to NASH remain poorly understood due to the lack of models that faithfully reflect the complexity of human disease. Hence, Halt-RONIN aims to uncover the early triggers of disease initiation and complex mechanistic drivers of disease progression by implementing a systems biology approach with integrative disease modelling resulting in opportunities for the improvement of the existing detection methods, providing a blueprint to inform personalized intervention strategies and drug discovery for NAFLD. To achieve this goal, Halt-RONIN will combine experimental data from advanced in vitro and in vivo models with multimodal data from extensive human NAFLD cohorts and biobanks and use in silico machine learning approaches, to discover new biomarkers and molecular targets specific to each stage of the health-to-disease transition. By validating preclinical experimental findings with real-world data, RONIN will allow for the discovery of novel biomarkers and molecular targets that are specific to the individual patient’s pathology. Consequently, healthcare professionals will gain the tools and knowledge required to diagnose and establish guidelines for the prevention and treatment of inflammation-driven health to disease. As such, in the long-term RONIN will decrease the number of NAFL patients who progress into NASH and provide disease-modifying strategies to improve patient outcomes.
Fields of science
- medical and health sciencesbasic medicinepharmacology and pharmacydrug discovery
- medical and health scienceshealth sciencesinflammatory diseases
- medical and health sciencesbasic medicinepathology
- medical and health sciencesclinical medicinehepatology
- natural sciencescomputer and information sciencesartificial intelligencemachine learning
Keywords
Programme(s)
Funding Scheme
HORIZON-RIA - HORIZON Research and Innovation ActionsCoordinator
28040 Madrid
Spain
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Participants (19)
35760 SAINT GREGOIRE
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
48160 DERIO VIZCAYA
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06800 Bilkent Ankara
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35340 İzmir
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
75654 Paris
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
35042 RENNES
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1099 085 Lisboa
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1649-003 Lisboa
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29016 Malaga
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08007 Barcelona
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
41071 Sevilla
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
29590 MALAGA
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28046 MADRID
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
28222 Majadahonda
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08036 Barcelona
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
08036 Barcelona
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39011 Santander
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
Santander
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28006 Madrid
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Partners (3)
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
02210 Boston
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
G12 8QQ Glasgow
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
EH8 9YL Edinburgh
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