Phototherapy treatment for long-term COVID-19 patients

Informazioni relative al progetto

longCOVID-UVBtherapy

ID dell’accordo di sovvenzione: 101101051

DOI

10.3030/101101051

Progetto chiuso

Data della firma CE 2 Febbraio 2023

Data di avvio 1 Settembre 2023

Data di completamento 28 Febbraio 2026

Finanziato da

• European Research Council (ERC)

Costo totale

Nessun dato

Contributo UE

€ 150 000,00

Coordinato da

TEL AVIV UNIVERSITY
Israel

Periodic Reporting for period 1 - longCOVID-UVBtherapy (Phototherapy treatment for long-term COVID-19 patients)

Periodo di rendicontazione: 2023-09-01 al 2026-02-28

Sintesi del contesto e degli obiettivi generali del progetto

Long-COVID has emerged as a major global healthcare challenge affecting millions of patients worldwide, with no effective treatment currently available. Persistent symptoms, including fatigue, cognitive impairment, mood disorders, and cardiopulmonary dysfunction, impose a substantial medical, social, and economic burden.
Based on our previous ERC-funded discoveries demonstrating that UVB exposure induces a systemic anti-inflammatory immune shift opposite to the long-COVID inflammatory profile, this project aims to validate phototherapy as a novel, non-invasive treatment for long-COVID patients.
The overall objective of the project is to establish and optimize a clinically applicable phototherapy protocol for long-COVID treatment through a controlled clinical trial, immune profiling, and patient-response analyses. In parallel, the project aims to prepare the foundation for rapid global dissemination and implementation of this therapy through existing phototherapy infrastructures.
If successful, this project may provide the first accessible and scalable treatment strategy for long-COVID, improving patient quality of life while reducing the burden on healthcare systems worldwide.

Lavoro eseguito dall’inizio del progetto fino alla fine del periodo coperto dalla relazione e principali risultati finora ottenuti

The major achievement of this ERC PoC project was the successful completion of a clinical phototherapy trial in long-COVID patients and the generation of highly encouraging clinical outcomes. Despite the transfer of clinical activities from Maccabi Healthcare Services to Tel-Aviv Sourasky Medical Center following the closure of the Maccabi phototherapy clinic, all planned milestones and objectives were successfully completed as originally proposed.
Most importantly, phototherapy-treated long-COVID patients demonstrated significant improvement across all reported symptoms compared to matched control patients, including prolonged symptom relief and reduced symptom recurrence over time. These findings provide the first clinical evidence supporting phototherapy as a potential non-invasive treatment strategy for long-COVID-associated manifestations.
In parallel, the project established the clinical, regulatory, and collaborative framework required for future expansion into larger clinical cohorts and eventual dissemination of the treatment protocol. The promising clinical results have already generated substantial interest within the medical community and initiated discussions regarding future integration of phototherapy into standard long-COVID treatment approaches.

Progressi oltre lo stato dell’arte e potenziale impatto previsto (incluso l’impatto socioeconomico e le implicazioni sociali più ampie del progetto fino ad ora)

This project provides the first clinical evidence supporting phototherapy as a potential non-invasive treatment for long-COVID patients. While current long-COVID management relies mainly on symptomatic and supportive care, our findings demonstrate that UVB phototherapy can induce significant improvement across multiple long-COVID symptom categories, including fatigue, cognitive/mood symptoms, and cardiopulmonary manifestations.
Beyond the clinical outcomes, the project establishes a translational framework linking UVB-mediated immune modulation with long-COVID-associated inflammatory dysregulation. The results therefore introduce a novel therapeutic concept that may be broadly applicable to post-viral inflammatory syndromes.
The strong clinical responses observed in the treated cohort generated substantial interest within the medical community and initiated discussions regarding future incorporation of phototherapy into standard long-COVID treatment protocols. However, larger validation cohorts and extended clinical studies are required before broad dissemination and implementation. Future steps will include expansion of the clinical cohort, further immune profiling, optimization of treatment protocols, publication of the results in a high-impact journal, and establishment of broader clinical and regulatory collaborations.
Overall, the project successfully advanced phototherapy for long-COVID from a conceptual hypothesis toward clinical proof-of-concept and demonstrated its strong translational and therapeutic potential.