Projektbeschreibung
Tragbares medizinisches Gerät zur Kontrolle von Diabetes und Adipositas
Typ-2-Diabetes und Adipositas sind multifaktorielle Erkrankungen. Somit müssen mehrere Biomarker überwacht werden, was durchaus schwierig ist. Aktuelle Geräte weisen erhebliche Mängel auf durch zu geringe Präzision, Größe und Komplexität. Finanziert über die Marie-Skłodowska-Curie-Maßnahmen wird im Projekt DVD-E vorgeschlagen, ein revolutionäres medizinisches Multiplexgerät zu entwickeln, um chronische Erkrankungen zu überwachen. In dem Gerät werden verschiedene Technologien kombiniert, darunter Optik, Elektrochemie, Mikrofluidik und Optoelektronik, um verschiedene Energiebiomarker zu erfassen, darunter ein neues Stoffwechselsuccinat. Mit diesem tragbaren und kostengünstigen Ansatz kann die Überwachung von chronischen Erkrankungen dezentralisiert und die Versorgung von Personen mit Typ-2-Diabetes und Adipositas verbessert werden.
Ziel
Obesity is one of the most common and costly chronic disorder worldwide, and is a causal or a strong risk factor for several comorbidities, as type 2 diabetes (T2D), which is now reaching epidemic proportions. To monitor multifactorial disorders such as obesity and T2D, clinical evidences from more than one energetic biomarker are crucial. Current multiplexed systems present limited multiplicity capacities because they combine individual tests spatially separated from the others requiring complex and bulky instruments (e.g. HPLC), so they are difficult to operate out of the laboratory. Other described tests also cannot be adapted to monitor chronic disorders because they present at least one of the following critical limitations: (1) they are semi-quantitative (e.g. lateral flow test) so cannot perform the analyte monitoring to the required level of precision, (2) restricted to a single analyte which does not address the accepted criteria that an obesity management requires clinical evidence from multiple biomarkers and/or (3) cannot integrate the microfluidic processing required for blood analysis.
To overcome current limitations, a novel multiplexed medical device is proposed here to enable for the very first time the fully control and management of chronic disorders as obesity and T2D. This will combine optics, electrochemistry, microfluidics and optoelectronics to monitor the most appropriate energy biomarkers (succinate as novel metabolite, in addition to lactate, ketones, pyruvate and glycaemia) in a friendly and decentralised way. No one has previously proposed a useful multiplexed approach as this, allowing the opportunity of the control of a particular energy biomarker such as succinate, which will facilitate current chronic disorders management. Thus, this novel cost-effective and portable multiplexed medical device, with unique and unprecedented attributes, will play a role key in the accurate management of chronic disorders.
Wissenschaftliches Gebiet
- natural sciencesphysical sciencesclassical mechanicsfluid mechanicsmicrofluidics
- natural scienceschemical sciencesorganic chemistryketones
- medical and health sciencesclinical medicineendocrinologydiabetes
- engineering and technologymedical engineeringmedical laboratory technologylaboratory samples analysis
- medical and health scienceshealth sciencesnutritionobesity
Schlüsselbegriffe
Programm/Programme
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Aufforderung zur Vorschlagseinreichung
Andere Projekte für diesen Aufruf anzeigenFinanzierungsplan
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European FellowshipsKoordinator
10691 Stockholm
Schweden