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CORDIS - Forschungsergebnisse der EU
CORDIS

Focusing on deep sleep-wake brain regions in the context of Alzheimer's disease pathogenesis: a multi-modal, high-resolution neuroimaging approach

CORDIS bietet Links zu öffentlichen Ergebnissen und Veröffentlichungen von HORIZONT-Projekten.

Links zu Ergebnissen und Veröffentlichungen von RP7-Projekten sowie Links zu einigen Typen spezifischer Ergebnisse wie Datensätzen und Software werden dynamisch von OpenAIRE abgerufen.

Leistungen

Data Management Plan (öffnet in neuem Fenster)

All research data and outputs derived from this project will be managed following the FAIR principles. They will be findable and accessible, as the HABS data and informatics team is currently building a novel IT infrastructure to improve the current procedure of open access and to facilitate/automatise data queries using an exhaustive set of descriptors and metadata information. Likewise, the WALLe group is in the process of being integrated to the Global Alzheimer’s Association Interactive Network (GAAIN) cohort inventory, which fosters data discovery, collaboration, and sharing through facilitated access to study variables in a transparent way across worldwide cohorts in AD research. In addition, as it represents a core aspect of this project, all neuroimaging data format and nomenclature will be standardized following the methods and recommendations from the Brain Imaging Data Structure (BIDS) initiative, ensuring that the project’s outputs are interoperable and reusable by third parties. Prior to the publication process, pre-prints describing the outputs from the different research objectives will be made available to the community on the most relevant pre-print servers (e.g. medRxiv, bioRxiv). All manuscripts generated will be published in open-access peer-reviewed journals only, and the accompanying anonymized data will be deposited on open data repositories, such as the Open Science Framework, OpenNeuro, or NeuroVault platforms. In addition, scripts and processing pipelines will be systematically described, commented, and shared with the community (e.g. via GitHub) to encourage replicability of the project’s methodologies and findings. Part of the HABS longitudinal dataset has already been made accessible to the public upon request, which yielded so far more than 40 additional research projects, and the HABS team is now working on releasing the next 5 years of the follow-up data. As per National Institutes of Health (NIH) open access regulations, both WALLe and HABS studies are committed to publicly releasing their full datasets within maximum 6 months after funding completion or after publication of their main research objectives, whichever comes first.

Veröffentlichungen

Sex differences in the relationships between 24-h rest-activity patterns and plasma markers of Alzheimer’s disease pathology (öffnet in neuem Fenster)

Autoren: Maxime Van Egroo, Elise Beckers, Nicholas J. Ashton, Kaj Blennow, Henrik Zetterberg, Heidi I. L. Jacobs
Veröffentlicht in: Alzheimer's Research & Therapy, Ausgabe 16, 2024, ISSN 1758-9193
Herausgeber: Springer Science and Business Media LLC
DOI: 10.1186/S13195-024-01653-Y

Locus coeruleus‐entorhinal cortex tract integrity is linked to plasma tau and glial fibrillary acidic protein (öffnet in neuem Fenster)

Autoren: Yuliya Patsyuk, Maxime Van Egroo, Elise Beckers, Elouise A. Koops, Nicholas J. Ashton, Shorena Janelidze, Kaj Blennow, Oskar Hansson, Henrik Zetterberg, Benedikt A. Poser, Heidi I. L. Jacobs
Veröffentlicht in: Alzheimer's & Dementia, Ausgabe 21, 2025, ISSN 1552-5260
Herausgeber: Wiley
DOI: 10.1002/ALZ.70915

Microstructural associations between locus coeruleus, cortical, and subcortical regions are modulated by astrocyte reactivity: a 7T MRI adult lifespan study (öffnet in neuem Fenster)

Autoren: Elise Beckers, Maxime Van Egroo, Nicholas J Ashton, Kaj Blennow, Gilles Vandewalle, Henrik Zetterberg, Benedikt A Poser, Heidi I L Jacobs
Veröffentlicht in: Cerebral Cortex, Ausgabe 34, 2024, ISSN 1047-3211
Herausgeber: Oxford University Press (OUP)
DOI: 10.1093/CERCOR/BHAE261

Associations of 24‐Hour Rest‐Activity Rhythm Fragmentation, Cognitive Decline, and Postmortem Locus Coeruleus Hypopigmentation in Alzheimer's Disease (öffnet in neuem Fenster)

Autoren: Maxime Van Egroo, Eus J.W. van Someren, Lea T. Grinberg, David A. Bennett, Heidi I.L. Jacobs
Veröffentlicht in: Annals of Neurology, Ausgabe 95, 2024, ISSN 0364-5134
Herausgeber: Wiley
DOI: 10.1002/ANA.26880

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