Project description
Haplotype genome assemblies and emergence of parthenogenesis
All species of roundworm genus Plectus reproduce exclusively asexually. How they lost their ability to reproduce sexually is unknown. Hybridisation between species, in which alleles from sexually reproducing species integrated into a closely related species, is one possibility, perhaps an adaptation to extreme environments. With the support of the Marie Skłodowska-Curie Actions programme, the CHOPPE project aims to investigate this. It will generate chromosome-level collapsed genome assemblies for several species of Plectus and its closest sexual relative Anaplectus from diverse habitats. New computational methods will generate fully phased haplotype assemblies (genes inherited from a single parent). The collapsed and haplotype assemblies could reveal the genomic basis of adaptation to extreme environments via parthenogenesis.
Objective
Sexual reproduction is a costly but seemingly necessary trait in animals. However, species in diverse branches of the animal kingdom have secondarily reverted to asexual reproduction. In the roundworms (phylum Nematoda), this reversal appears particularly frequent, as parthenogenetic species have emerged in numerous genera. Species in the genus Plectus are obligately parthenogenetic, and are distributed in non-extreme and extreme environments across the globe. Mechanisms leading to the loss of sex, for example hybridisation, have received some attention, but are still poorly understood, in particular on the genomic level. This is in part due to the lack of sequencing and analysis tools for complex genomes of minute organisms.
CHOPPE will generate chromosome-level collapsed and phased genome assemblies using latest assembly strategies for several species of Plectus and its closest sexual relative Anaplectus from diverse habitats. CHOPPE will develop new computational methods for generating fully phased assemblies of diverse non-model species. Collapsed assemblies, and haplotype assemblies of several Plectus and Anaplectus species generated in the project, will allow to decipher the genomic basis of their adaption in the context of parthenogenesis and extreme environments. The project will further investigate the reversal to sexuality of Plectus through crossing with heat induced males, and establish this genus as a new model for the study of parthenogenesis.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences computer and information sciences computational science
- natural sciences biological sciences genetics genomes
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Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-PF-01
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50931 Koln
Germany
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