Novel targeted Intervention to Treat Anemia

Ziel

Anemia, defined as a decreased quantity of circulating red blood cells, is a major source of morbidity and mortality affecting a-third of the worldwide population. As a functional component of erythrocytes hemoglobin, iron is essential for oxygen storage and transport. The liver-derived peptide hepcidin is the master regulator of iron homeostasis. During anemia, the erythroid hormone erythroferrone regulates hepcidin synthesis to ensure the proper supply of iron to the bone marrow for red blood cells synthesis. However, we provided evidence that another factor may exert a similar function. We identified a previously undescribed suppressor of hepcidin that is highly induced in the liver in response to hypoxia during the recovery from anemia and in thalassemic mice. We demonstrated that this hepatokine is a potent suppressor of hepcidin in vitro and in vivo. Our aims is to investigate the therapeutic potential of its manipulation in murine models of anemia. Successful completion of this project will lead to the development of new therapeutic strategies for the treatment of various forms of anemias for which current treatments remain largely ineffective.

Wissenschaftliches Gebiet

Koordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE

Netto-EU-Beitrag

€ 150 000,00

Adresse

Rue de tolbiac 101
75654 Paris
Frankreich

Region

Ile-de-France Ile-de-France Paris

Aktivitätstyp

Research Organisations

Links

Die Organisation kontaktieren Website

Teilnahme an EU-FuI-Programmen

HORIZON-Kooperationsnetzwerk

EU-Beitrag

Keine Daten

Ziel

Wissenschaftliches Gebiet

Schlüsselbegriffe

Programm/Programme

Thema/Themen

Aufforderung zur Vorschlagseinreichung

Finanzierungsplan

Koordinator

Diese Seite teilen

Herunterladen