Cel Anemia, defined as a decreased quantity of circulating red blood cells, is a major source of morbidity and mortality affecting a-third of the worldwide population. As a functional component of erythrocytes hemoglobin, iron is essential for oxygen storage and transport. The liver-derived peptide hepcidin is the master regulator of iron homeostasis. During anemia, the erythroid hormone erythroferrone regulates hepcidin synthesis to ensure the proper supply of iron to the bone marrow for red blood cells synthesis. However, we provided evidence that another factor may exert a similar function. We identified a previously undescribed suppressor of hepcidin that is highly induced in the liver in response to hypoxia during the recovery from anemia and in thalassemic mice. We demonstrated that this hepatokine is a potent suppressor of hepcidin in vitro and in vivo. Our aims is to investigate the therapeutic potential of its manipulation in murine models of anemia. Successful completion of this project will lead to the development of new therapeutic strategies for the treatment of various forms of anemias for which current treatments remain largely ineffective. Dziedzina nauki nauki społecznesocjologiademografiaśmiertelnośćnauki przyrodniczenauki biologicznebiochemiabiocząsteczkimedycyna i nauki o zdrowiumedycyna klinicznahematologiamedycyna i nauki o zdrowiumedycyna klinicznafizjologiahomeostaza Słowa kluczowe NITA Program(-y) HORIZON.1.1 - European Research Council (ERC) Main Programme Temat(-y) ERC-2022-POC2 - ERC PROOF OF CONCEPT GRANTS2 Zaproszenie do składania wniosków ERC-2022-POC2 Zobacz inne projekty w ramach tego zaproszenia System finansowania HORIZON-ERC-POC - HORIZON ERC Proof of Concept Grants Koordynator INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Wkład UE netto € 150 000,00 Adres Rue de tolbiac 101 75654 Paris Francja Zobacz na mapie Region Ile-de-France Ile-de-France Paris Rodzaj działalności Research Organisations Linki Kontakt z organizacją Opens in new window Strona internetowa Opens in new window Uczestnictwo w unijnych programach w zakresie badań i innowacji Opens in new window sieć współpracy HORIZON Opens in new window Wkład UE Brak danych
