NaV1.5 regulation fine-tuning as a therapy for cardiac Conduction and Arrhythmic diseases at Risk of suddEn Death

Project Information

NaV1.5-CARED

Grant agreement ID: 101115295

DOI

10.3030/101115295

EC signature date 21 June 2023

Start date 1 October 2023

End date 30 September 2028

Funded under

• The European Innovation Council (EIC)

Total cost

€ 4 892 256,25

EU contribution

€ 4 892 256,25

Coordinated by

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

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Deliverables

Other (1)

Website and project logo

Documents, reports (1)

Plan for Dissemination and Communication Activities

Plan for Dissemination and Communication ActivitiesVersion 1

Publications

Peer reviewed articles (8)

Top stories on genome-wide association studies

Author(s): Connie Bezzina, Alex Lipov, Roddy Walsh
Published in: Heart Rhythm, Issue 21, 2024, ISSN 1547-5271
Publisher: Elsevier BV
DOI: 10.1016/j.hrthm.2024.06.005

Automated patch clamp data improve variant classification and penetrance stratification for <i>SCN5A</i> –Brugada syndrome

Author(s): Matthew J O’Neill, Joanne G Ma, Jessa L Aldridge, Joseph F Solus, Genevieve R Harvey, Paige H Roberson, Julien Barc, Connie R Bezzina, Dan M Roden, Roddy Walsh, Jamie I Vandenberg, Andrew M Glazer, Chai-Ann Ng
Published in: European Heart Journal, 2025, ISSN 0195-668X
Publisher: Oxford University Press (OUP)
DOI: 10.1093/EURHEARTJ/EHAF874

Long-term prognosis of patients with an SCN5A loss-of-function variant and progressive cardiac conduction disorder or Brugada syndrome

Author(s): Fenna Tuijnenburg, Virginnio M. Proost, Aurélie Thollet, Julien Barc, Alexander J.A. Groffen, Christiaan C. Veerman, Saskia N. van der Crabben, Vincent R. van der Pas, Florence Kyndt, Sean J. Jurgens, Michael W.T. Tanck, Pieter G. Postema, J. Peter van Tintelen, Connie R. Bezzina, Vincent Probst, Arthur A.M. Wilde, Jean-Baptiste Gourraud, Ahmad S. Amin
Published in: Heart Rhythm, 2024, ISSN 1547-5271
Publisher: Elsevier BV
DOI: 10.1016/j.hrthm.2024.10.057

PITX2 dosage-dependent changes in pacemaker cell state underlie sinus node dysfunction and atrial arrhythmias

Author(s): Lieve E. van der Maarel, M. Ridwane Mungroo, Otto J. Mulleners, Mathilde R. Rivaud, Arie O. Verkerk, Karel van Duijvenboden, Freek H. T. Tiel Groenestege, Jeffrey D. Steimle, Lianne Fokkert, Corrie de Gier-de Vries, Mischa Klerk, Arie. R. Boender, James F. Martin, Bjarke Jensen, Gerard J. J. Boink, Harsha D. Devalla, Vincent M. Christoffels
Published in: Nature Communications, Issue 16, 2025, ISSN 2041-1723
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-66959-3

A Rare Noncoding Enhancer Variant in <i>SCN5A</i> Contributes to the High Prevalence of Brugada Syndrome in Thailand

Author(s): Roddy Walsh, John Mauleekoonphairoj, Isabella Mengarelli, Fernanda M. Bosada, Arie O. Verkerk, Karel van Duijvenboden, Yong Poovorawan, Wanwarang Wongcharoen, Boosamas Sutjaporn, Pharawee Wandee, Nitinan Chimparlee, Ronpichai Chokesuwattanaskul, Kornkiat Vongpaisarnsin, Piyawan Dangkao, Cheng-I Wu, Rafik Tadros, Ahmad S. Amin, Krystien V.V. Lieve, Pieter G. Postema, Maarten Kooyman, Leander Beekman, Dujdao Sahasatas, Montawatt Amnueypol, Rungroj Krittayaphong, Somchai Prechawat, Alisara Anannab, Pattarapong Makarawate, Tachapong Ngarmukos, Keerapa Phusanti, Gumpanart Veerakul, Zoya Kingsbury, Taksina Newington, Uma Maheswari, Mark T. Ross, Andrew Grace, Pier D. Lambiase, Elijah R. Behr, Jean-Jacques Schott, Richard Redon, Julien Barc, Vincent M. Christoffels, Arthur A.M. Wilde, Koonlawee Nademanee, Connie R. Bezzina, Apichai Khongphatthanayothin
Published in: Circulation, 2024, ISSN 0009-7322
Publisher: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1161/CIRCULATIONAHA.124.069041

Causal inference in the field of arrhythmia: An introduction to mendelian randomization

Author(s): Eva Lukas, Margot van de Weijer, Jacob Bergstedt, Connie R. Bezzina, Jorien L. Treur
Published in: Heart Rhythm, 2024, ISSN 1547-5271
Publisher: Elsevier BV
DOI: 10.1016/j.hrthm.2024.07.015

AAV6 vectors provide superior gene transfer compared to AAV9 vectors following intramyocardial administration

Author(s): Jianan Wang, Timo Jonker, Aina Cervera-Barea, Zhenyu Dong, Ruud N. Visser, Evelien E. Birza, Arie R. Boender, Mischa Klerk, Yuting Yang, Joyce Visser, Marlijn S. Jansen, Tom C. Grootswagers, Cindy I. Bart, Saskia C.A. de Jager, Silke Schrödel, Christian Thirion, Osne F. Kirzner, Hanno L. Tan, Antoine A.F. de Vries, Joost P.G. Sluijter, Klaus Neef, Joris R. de Groot, Vincent M. Christoffels, Gerard J.J. Boink
Published in: Molecular Therapy Methods &amp; Clinical Development, Issue 33, 2025, ISSN 2329-0501
Publisher: Elsevier BV
DOI: 10.1016/J.OMTM.2025.101532

<i>SCN10A-short</i> gene therapy to restore conduction and protect against malignant cardiac arrhythmias

Author(s): Jianan Wang, Arie O Verkerk, Ronald Wilders, Yingnan Zhang, Kelly Zhang, Adityo Prakosa, Mathilde R Rivaud, E Madelief J Marsman, Arie R Boender, Mischa Klerk, Lianne Fokkert, Berend de Jonge, Klaus Neef, Osne F Kirzner, Connie R Bezzina, Carol Ann Remme, Hanno L Tan, Bastiaan J Boukens, Harsha D Devalla, Natalia A Trayanova, Vincent M Christoffels, Phil Barnett, Gerard J J Boink
Published in: European Heart Journal, Issue 46, 2025, ISSN 0195-668X
Publisher: Oxford University Press (OUP)
DOI: 10.1093/EURHEARTJ/EHAF053