Next Generation Molecular Data Storage

Información del proyecto

NEO

Identificador del acuerdo de subvención: 101115317

DOI

10.3030/101115317

Fecha de la firma de la CE 2 Junio 2023

Fecha de inicio 1 Octubre 2023

Fecha de finalización 30 Septiembre 2026

Financiado con arreglo a

• The European Innovation Council (EIC)

Coste total

€ 2 418 514,98

Aportación de la UE

€ 2 418 514,98

Coordinado por

UNIVERSITAET PADERBORN
Germany

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (5)

Plan for Dissemination and Communication Activities

Define the Dissemination and Communication Plan

Website and project logo

Website and project logo information with also social media links

Demonstration of 6-way DNA strand displacement reactions

6-way DNA strand displacement reactions are demonstrated on DNA origami substrates. The speeds of 30 individual reactions are determined in solution and on surfaces in order to identify specific effects of surface immobilization.

Cost efficient folding of DNA nanostructures

An optimized protocol for low-cost folding of DNA origami nanostructures is developed that employs a minimum amount of staple strands in DNA origami assembly and enables the recycling of unincorporated staple strands after purification.

Basic characterisation of nanostructure using AFM

Reproducible imaging of molecular bumps embedded within the DNA origami nanostructures is demonstrated. Relatively non-invasive (soft) AFM imaging modes are employed in order maximize the resilience of the molecular bits to the repetitive reading process.

Data Management Plan (1)

Data Management plan

Define the Data Management Plan

Publicaciones

Peer reviewed articles (9)

Stability of Information‐Carrying DNA Origami Nanostructures During Repeated Freeze–Thaw Cycles

Autores: Xinyang Li, Lukas Rabbe, Jacqueline Linneweber, Guido Grundmeier, Adrian Keller
Publicado en: Chemistry–Methods, Edición 6, 2026, ISSN 2628-9725
Editor: Wiley
DOI: 10.1002/CMTD.202500161

Global Quantitative Analysis of Ligation Reactions in Self‐Assembled DNA Nanostructures at the Single‐Nick Level

Autores: Konrad Hacker, Emilia Juricke, Carolin Münch, Antonio Suma, Adrian Keller, Yixin Zhang
Publicado en: Small, Edición 22, 2026, ISSN 1613-6810
Editor: Wiley
DOI: 10.1101/2025.06.18.660358

Cost-efficient folding of functionalized DNA origami nanostructures <i>via</i> staple recycling

Autores: Emilia Tomm, Guido Grundmeier, Adrian Keller
Publicado en: Nanoscale, Edición 17, 2025, ISSN 2040-3364
Editor: Royal Society of Chemistry (RSC)
DOI: 10.1039/D5NR01435B

Evaluation of Structural Vulnerabilities in DNA Origami Nanoplatforms Using Ionizing Radiation

Autores: Leo Sala, Václav Olšanský, David Chvátil, François Chevalier, Violaine Vizcaino, Alain Méry, Jaroslav Kočišek
Publicado en: ChemNanoMat, Edición 12, 2026, ISSN 2199-692X
Editor: Wiley
DOI: 10.1002/CNMA.202500796

An End-to-End Coding Scheme for DNA-Based Data Storage With Nanopore-Sequenced Reads

Autores: Lorenz Welter, Roman Sokolovskii, Thomas Heinis, Antonia Wachter-Zeh, Eirik Rosnes, Alexandre Graell i Amat
Publicado en: IEEE Journal on Selected Areas in Information Theory, Edición 7, 2026, ISSN 2641-8770
Editor: Institute of Electrical and Electronics Engineers (IEEE)
DOI: 10.1109/JSAIT.2026.3655592

CpG Methylation Protects DNA against Ionizing Radiation

Autores: Leo Sala, Tereza Zápotocká, Jana Šáchová, Václav Olšanský, David Chvátil, François Chevalier, Violaine Vizcaino, Alain Méry, Jaroslav Kočišek
Publicado en: The Journal of Physical Chemistry B, Edición 129, 2025, ISSN 1520-6106
Editor: American Chemical Society (ACS)
DOI: 10.1021/ACS.JPCB.5C04043

Motif caller for sequence reconstruction in motif-based DNA storage

Autores: Parv Agarwal, Nimesh Pinnamaneni, Thomas Heinis
Publicado en: Scientific Reports, Edición 15, 2025, ISSN 2045-2322
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S41598-025-22798-2

Toward high-density streptavidin arrays on DNA origami nanostructures

Autores: Lukas Rabbe, Emilia Tomm, Guido Grundmeier, Adrian Keller
Publicado en: RSC Advances, Edición 15, 2025, ISSN 2046-2069
Editor: Royal Society of Chemistry (RSC)
DOI: 10.1039/D5RA03393D

Breaking of the Up‐Down Symmetry of DNA Origami on a Solid Substrate

Autores: Gangamallaiah Velpula, Emilia Tomm, Boxuan Shen, Kunal S. Mali, Adrian Keller, Steven De Feyter
Publicado en: Angewandte Chemie, Edición 137, 2025, ISSN 0044-8249
Editor: Wiley
DOI: 10.1002/ANGE.202507613

Thesis and dissertations (2)

Human-in-the-Loop Few-Shot Annotation of DNA Origami in AFM Images

Autores: Paul Alexander Plantosar
Publicado en: 2025
Editor: Graz University of Technology (TU Graz)

Unsupervised Shape Detection and Mask-Conditioned Image Synthesis for DNA Origami

Autores: Noah Ruhmer
Publicado en: 2024
Editor: Graz University of Technology (TU Graz)

Conference proceedings (4)

Beyond Logarithmic Bounds: Querying in Constant Expected Time with Learned Indexes

Autores: Luis Alberto Croquevielle; Guang Yang; Liang Liang; Ali Hadian; Thomas Heinis
Publicado en: 28th International Conference on Database Theory (ICDT 2025), Edición 328, 2025, ISSN 1868-8969
Editor: Schloss Dagstuhl – Leibniz-Zentrum für Informatik
DOI: 10.4230/LIPICS.ICDT.2025.19

Effective Diffusion-free Score Matching for Exact Conditional Sampling – TPM/UAI Workshop 2025

Autores: Thomas Wedenig, Robert Peharz
Publicado en: 8th Workshop on Tractable Probabilistic Modeling (TPM 2025), UAI 2025
Editor: OpenReview.net

Exact Soft Analytical Side-Channel Attacks using Tractable Circuits – ICML 2024

Autores: Thomas Wedenig, Rishub Nagpal, Gaëtan Cassiers, Stefan Mangard, Robert Peharz
Publicado en: Proceedings of the 41st International Conference on Machine Learning
Editor: PMLR (Proceedings of Machine Learning Research)
DOI: 10.48550/ARXIV.2501.13748

Lower Bounds for the Algorithmic Complexity of Learned Indexes

Autores: Luis Alberto Croquevielle; Roman Sokolovskii; Thomas Heinis
Publicado en: 29th International Conference on Database Theory (ICDT 2026), Edición 365, 2026, ISSN 1868-8969
Editor: Schloss Dagstuhl – Leibniz-Zentrum für Informatik
DOI: 10.4230/LIPICS.ICDT.2026.14