Next Generation Molecular Data Storage

Informazioni relative al progetto

NEO

ID dell’accordo di sovvenzione: 101115317

DOI

10.3030/101115317

Data della firma CE 2 Giugno 2023

Data di avvio 1 Ottobre 2023

Data di completamento 30 Settembre 2026

Finanziato da

• The European Innovation Council (EIC)

Costo totale

€ 2 418 514,98

Contributo UE

€ 2 418 514,98

Coordinato da

UNIVERSITAET PADERBORN
Germany

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (5)

Plan for Dissemination and Communication Activities

Define the Dissemination and Communication Plan

Website and project logo

Website and project logo information with also social media links

Demonstration of 6-way DNA strand displacement reactions

6-way DNA strand displacement reactions are demonstrated on DNA origami substrates. The speeds of 30 individual reactions are determined in solution and on surfaces in order to identify specific effects of surface immobilization.

Cost efficient folding of DNA nanostructures

An optimized protocol for low-cost folding of DNA origami nanostructures is developed that employs a minimum amount of staple strands in DNA origami assembly and enables the recycling of unincorporated staple strands after purification.

Basic characterisation of nanostructure using AFM

Reproducible imaging of molecular bumps embedded within the DNA origami nanostructures is demonstrated. Relatively non-invasive (soft) AFM imaging modes are employed in order maximize the resilience of the molecular bits to the repetitive reading process.

Data Management Plan (1)

Data Management plan

Define the Data Management Plan

Pubblicazioni

Peer reviewed articles (9)

Stability of Information‐Carrying DNA Origami Nanostructures During Repeated Freeze–Thaw Cycles

Autori: Xinyang Li, Lukas Rabbe, Jacqueline Linneweber, Guido Grundmeier, Adrian Keller
Pubblicato in: Chemistry–Methods, Numero 6, 2026, ISSN 2628-9725
Editore: Wiley
DOI: 10.1002/CMTD.202500161

Global Quantitative Analysis of Ligation Reactions in Self‐Assembled DNA Nanostructures at the Single‐Nick Level

Autori: Konrad Hacker, Emilia Juricke, Carolin Münch, Antonio Suma, Adrian Keller, Yixin Zhang
Pubblicato in: Small, Numero 22, 2026, ISSN 1613-6810
Editore: Wiley
DOI: 10.1101/2025.06.18.660358

Cost-efficient folding of functionalized DNA origami nanostructures <i>via</i> staple recycling

Autori: Emilia Tomm, Guido Grundmeier, Adrian Keller
Pubblicato in: Nanoscale, Numero 17, 2025, ISSN 2040-3364
Editore: Royal Society of Chemistry (RSC)
DOI: 10.1039/D5NR01435B

Evaluation of Structural Vulnerabilities in DNA Origami Nanoplatforms Using Ionizing Radiation

Autori: Leo Sala, Václav Olšanský, David Chvátil, François Chevalier, Violaine Vizcaino, Alain Méry, Jaroslav Kočišek
Pubblicato in: ChemNanoMat, Numero 12, 2026, ISSN 2199-692X
Editore: Wiley
DOI: 10.1002/CNMA.202500796

An End-to-End Coding Scheme for DNA-Based Data Storage With Nanopore-Sequenced Reads

Autori: Lorenz Welter, Roman Sokolovskii, Thomas Heinis, Antonia Wachter-Zeh, Eirik Rosnes, Alexandre Graell i Amat
Pubblicato in: IEEE Journal on Selected Areas in Information Theory, Numero 7, 2026, ISSN 2641-8770
Editore: Institute of Electrical and Electronics Engineers (IEEE)
DOI: 10.1109/JSAIT.2026.3655592

CpG Methylation Protects DNA against Ionizing Radiation

Autori: Leo Sala, Tereza Zápotocká, Jana Šáchová, Václav Olšanský, David Chvátil, François Chevalier, Violaine Vizcaino, Alain Méry, Jaroslav Kočišek
Pubblicato in: The Journal of Physical Chemistry B, Numero 129, 2025, ISSN 1520-6106
Editore: American Chemical Society (ACS)
DOI: 10.1021/ACS.JPCB.5C04043

Motif caller for sequence reconstruction in motif-based DNA storage

Autori: Parv Agarwal, Nimesh Pinnamaneni, Thomas Heinis
Pubblicato in: Scientific Reports, Numero 15, 2025, ISSN 2045-2322
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41598-025-22798-2

Toward high-density streptavidin arrays on DNA origami nanostructures

Autori: Lukas Rabbe, Emilia Tomm, Guido Grundmeier, Adrian Keller
Pubblicato in: RSC Advances, Numero 15, 2025, ISSN 2046-2069
Editore: Royal Society of Chemistry (RSC)
DOI: 10.1039/D5RA03393D

Breaking of the Up‐Down Symmetry of DNA Origami on a Solid Substrate

Autori: Gangamallaiah Velpula, Emilia Tomm, Boxuan Shen, Kunal S. Mali, Adrian Keller, Steven De Feyter
Pubblicato in: Angewandte Chemie, Numero 137, 2025, ISSN 0044-8249
Editore: Wiley
DOI: 10.1002/ANGE.202507613

Thesis and dissertations (2)

Human-in-the-Loop Few-Shot Annotation of DNA Origami in AFM Images

Autori: Paul Alexander Plantosar
Pubblicato in: 2025
Editore: Graz University of Technology (TU Graz)

Unsupervised Shape Detection and Mask-Conditioned Image Synthesis for DNA Origami

Autori: Noah Ruhmer
Pubblicato in: 2024
Editore: Graz University of Technology (TU Graz)

Conference proceedings (4)

Beyond Logarithmic Bounds: Querying in Constant Expected Time with Learned Indexes

Autori: Luis Alberto Croquevielle; Guang Yang; Liang Liang; Ali Hadian; Thomas Heinis
Pubblicato in: 28th International Conference on Database Theory (ICDT 2025), Numero 328, 2025, ISSN 1868-8969
Editore: Schloss Dagstuhl – Leibniz-Zentrum für Informatik
DOI: 10.4230/LIPICS.ICDT.2025.19

Effective Diffusion-free Score Matching for Exact Conditional Sampling – TPM/UAI Workshop 2025

Autori: Thomas Wedenig, Robert Peharz
Pubblicato in: 8th Workshop on Tractable Probabilistic Modeling (TPM 2025), UAI 2025
Editore: OpenReview.net

Exact Soft Analytical Side-Channel Attacks using Tractable Circuits – ICML 2024

Autori: Thomas Wedenig, Rishub Nagpal, Gaëtan Cassiers, Stefan Mangard, Robert Peharz
Pubblicato in: Proceedings of the 41st International Conference on Machine Learning
Editore: PMLR (Proceedings of Machine Learning Research)
DOI: 10.48550/ARXIV.2501.13748

Lower Bounds for the Algorithmic Complexity of Learned Indexes

Autori: Luis Alberto Croquevielle; Roman Sokolovskii; Thomas Heinis
Pubblicato in: 29th International Conference on Database Theory (ICDT 2026), Numero 365, 2026, ISSN 1868-8969
Editore: Schloss Dagstuhl – Leibniz-Zentrum für Informatik
DOI: 10.4230/LIPICS.ICDT.2026.14