MultiomIcs based Risk stratification of Atherosclerotic CardiovascuLar disEase

Informations projet

MIRACLE

N° de convention de subvention: 101115381

DOI

10.3030/101115381

Date de signature de la CE 14 Juin 2023

Date de début 1 Octobre 2023

Date de fin 30 Septembre 2027

Financé au titre de

• The European Innovation Council (EIC)

Coût total

€ 4 599 866,25

Contribution de l’UE

€ 4 599 866,25

Coordonné par

ITA-SUOMEN YLIOPISTO
Finland

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Documents, reports (3)

General Assembly Meeting-1

Online meeting with Partner PIs. Project planning and tracking report (minutes/PPTs) (Tasks 5.1-2)

Website and project logo

Website and project logo information with social media links (Task 5.3)

Sex-stratified clusters of plaques

Define and report sex specific plaque clusters (Task 2.1)

Data Management Plan (1)

Data Management plan

Describes the data management life cycle (Task 5.1)

Publications

Peer reviewed articles (15)

Arteriosclerosis, Thrombosis, and Vascular Biology

Auteurs: Ilakya Selvarajan; Miika Kiema; Ru-Ting Huang; Jin Li; Jiayu Zhu; Petri Pölönen; Tiit Örd; Kadri Õunap; Mehvash Godiwala; Anna Kathryn Golebiewski; Aarthi Ravindran; Kiira Mäklin; Anu Toropainen; Lindsey K. Stolze; Maximiliano Arce; Peetra U. Magnusson; Stephen White; Casey E. Romanoski; Merja Heinäniemi; Johanna P. Laakkonen; Yun Fang; Minna U. Kaikkonen
Publié dans: Arteriosclerosis, Thrombosis, and Vascular Biology, Numéro 44, 2024, ISSN 1079-5642
Éditeur: American Heart Association
DOI: 10.1161/ATVBAHA.123.318964

Predicting the genetic component of gene expression using gene regulatory networks

Auteurs: Gutama Ibrahim Mohammad; Tom Michoel
Publié dans: Bioinformatics Advances, 2024, ISSN 2635-0041
Éditeur: Oxford University Press
DOI: 10.48550/ARXIV.2408.08530

Clonal haematopoiesis of indeterminate potential and mortality in coronary artery disease

Auteurs: Moritz von Scheidt, Shaunak S Adkar, Johannes Krefting, Gregor Hoermann, Manja Meggendorfer, Sabine Bauer, Shaneice Mitchell, Irina Pugach, Christian Friess, Angela Ma, Ke Hao, Sophia Steigerwald, Maria Wahle, Thorsten Kessler, Marius Schwab, Felix Voll, Michal Mokry, Charalampos Sofokleous, Kaylin C A Palm, Dario Bongiovanni, Julia Fleig, Lilith Oldenbuettel, Zhifen Chen, Judith S Hecker, Florian Bassermann, Lars Maegdefessel, Matthias Graw, Arno Ruusalepp, Ingo Hilgendorf, Florian Leuschner, Hendrik B Sager, J Brett Heimlich, Wolfgang Koenig, Sebastian Cremer, David M Leistner, Wesley T Abplanalp, Stefanie Dimmeler, Andreas M Zeiher, Sander W van der Laan, Gerard Pasterkamp, Christian Braun, Siddhartha Jaiswal, Jason C Kovacic, Wolfgang Kern, Claudia Haferlach, Matthias Mann, Salvatore Cassese, Adnan Kastrati, Torsten Haferlach, Nicholas J Leeper, Johan L M Björkegren, Heribert Schunkert
Publié dans: European Heart Journal, Numéro 47, 2026, ISSN 0195-668X
Éditeur: Oxford University Press (OUP)
DOI: 10.1093/EURHEARTJ/EHAF602

Evidence of survival bias in the association between APOE-Є4 and age at ischemic stroke onset

Auteurs: Joanna von Berg, Patrick F. McArdle, Paavo Häppölä, Jeffrey Haessler, Charles Kooperberg, Robin Lemmens, Alessandro Pezzini, Vincent Thijs, Sara L. Pulit, Steven J. Kittner, Braxton D. Mitchell, Jeroen de Ridder, Sander W. van der Laan
Publié dans: Frontiers in Genetics, Numéro 15, 2024, ISSN 1664-8021
Éditeur: Frontiers Media SA
DOI: 10.3389/fgene.2024.1392061

Prediction of causal genes at GWAS loci with pleiotropic gene regulatory effects using sets of correlated instrumental variables

Auteurs: Mariyam Khan; Adriaan-Alexander Ludl; Sean Bankier; Johan L. M. Björkegren; Tom Michoel
Publié dans: PLOS Genetics, 2024, ISSN 1553-7404
Éditeur: Public Library of Science (PLOS)
DOI: 10.48550/ARXIV.2401.06261

Single-Cell Gene-Regulatory Networks of Advanced Symptomatic Atherosclerosis

Auteurs: Giuseppe Mocci, Katyayani Sukhavasi, Tiit Örd, Sean Bankier, Prosanta Singha, Uma Thanigai Arasu, Olayinka Oluwasegun Agbabiaje, Petri Mäkinen, Lijiang Ma, Chani J. Hodonsky, Redouane Aherrahrou, Lars Muhl, Jianping Liu, Sonja Gustafsson, Byambajav Byandelger, Ying Wang, Simon Koplev, Urban Lendahl, Gary K. Owens, Nicholas J. Leeper, Gerard Pasterkamp, Michael Vanlandewijck, Tom Michoel, Arno Ruusalepp, Ke Hao, Seppo Ylä-Herttuala, Marika Väli, Heli Järve, Michal Mokry, Mete Civelek, Clint J. Miller, Jason C. Kovacic, Minna U. Kaikkonen, Christer Betsholtz, Johan L.M. Björkegren
Publié dans: Circulation Research, Numéro 134, 2024, ISSN 0009-7330
Éditeur: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1161/CIRCRESAHA.123.323184

Integration of a polygenic score into guideline-recommended prediction of cardiovascular disease

Auteurs: Ling Li, Shichao Pang, Fabian Starnecker, Bertram Mueller-Myhsok, Heribert Schunkert
Publié dans: European Heart Journal, Numéro 45, 2024, ISSN 0195-668X
Éditeur: Oxford University Press (OUP)
DOI: 10.1093/eurheartj/ehae048

Circulating causal protein networks linked to future risk of myocardial infarction

Auteurs: Sean Bankier, Valborg Gudmundsdottir, Thorarinn Jonmundsson, Heida Bjarnadottir, Joseph Loureiro, Lingfei Wang, Elísabet A. Frick, Nancy Finkel, Anthony P. Orth, Thor Aspelund, Lenore J. Launer, Johan L. M. Björkegren, Lori L. Jennings, John R. Lamb, Vilmundur Gudnason, Tom Michoel, Valur Emilsson
Publié dans: Nature Communications, Numéro 17, 2026, ISSN 2041-1723
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-67135-3

Clinical utility and implementation of polygenic risk scores for predicting cardiovascular disease

Auteurs: Heribert Schunkert, Emanuele Di Angelantonio, Michael Inouye, Riyaz S Patel, Samuli Ripatti, Elisabeth Widen, Saskia C Sanderson, Juan Pablo Kaski, John W McEvoy, Panos Vardas, Angela Wood, Victor Aboyans, Vassilios S Vassiliou, Frank L J Visseren, Luis R Lopes, Perry Elliott, Maryam Kavousi
Publié dans: European Heart Journal, Numéro 46, 2025, ISSN 0195-668X
Éditeur: Oxford University Press (OUP)
DOI: 10.1093/EURHEARTJ/EHAE649

Single-cell RNA sequencing reveals sex differences in the subcellular composition and associated gene-regulatory network activity of human carotid plaques

Auteurs: Katyayani Sukhavasi; Giuseppe Mocci; Lijiang Ma; Chani J. Hodonsky; Ernest Diez Benevante; Lars Muhl; Jianping Liu; Sonja Gustafsson; Byambajav Buyandelger; Simon Koplev; Urban Lendahl; Michael Vanlandewijck; Prosanta Singha; Tiit Örd; Mustafa Beter; Ilakya Selvarajan; Johanna P. Laakkonen; Marika Väli; Hester M. den Ruijter; Mete Civelek; Ke Hao; Arno Ruusalepp; Christer Betsholtz; Heli Järve; Jason C. Kovacic; Clint L. Miller; Casey Romanoski; Minna U. Kaikkonen; Johan L. M. Björkegren
Publié dans: Nature Cardiovascular Research, 2025, ISSN 2731-0590
Éditeur: Springer Nature
DOI: 10.1038/S44161-025-00628-Y

Proteomics of mouse brain endothelium uncovers dysregulation of vesicular transport pathways during aging

Auteurs: Katalin Todorov-Völgyi; Judit González-Gallego; Stephan A. Müller; Nathalie Beaufort; Rainer Malik; Martina Schifferer; Mihail Ivilinov Todorov; Dennis Crusius; Sophie Robinson; Andree Schmidt; Jakob Körbelin; Florence Bareyre; Ali Ertürk; Christian Haass; Mikael Simons; Dominik Paquet; Stefan F. Lichtenthaler; Martin Dichgans
Publié dans: Nature Aging, 2024, ISSN 2662-8465
Éditeur: Nature
DOI: 10.1038/S43587-024-00598-Z

The Effects of FABP4 on Cardiovascular Disease in the Aging Population

Auteurs: Ellen M. van der Ark-Vonk, Mike V. Puijk, Gerard Pasterkamp, Sander W. van der Laan
Publié dans: Current Atherosclerosis Reports, Numéro 26, 2024, ISSN 1523-3804
Éditeur: Springer Science and Business Media LLC
DOI: 10.1007/s11883-024-01196-5

Genetic variation drives differences in obesity-related gene regulation

Auteurs: Minna U. Kaikkonen
Publié dans: Trends in Genetics, Numéro 40, 2024, ISSN 0168-9525
Éditeur: Elsevier BV
DOI: 10.1016/j.tig.2024.02.009

Proteogenomic Data Integration Reveals CXCL10 as a Potentially Downstream Causal Mediator for IL-6 Signaling on Atherosclerosis

Auteurs: Savvina Prapiadou, Luka Živković, Barbara Thorand, Marc J. George, Sander W. van der Laan, Rainer Malik, Christian Herder, Wolfgang Koenig, Thor Ueland, Ola Kleveland, Pål Aukrust, Lars Gullestad, Jürgen Bernhagen, Gerard Pasterkamp, Annette Peters, Aroon D. Hingorani, Jonathan Rosand, Martin Dichgans, Christopher D. Anderson, Marios K. Georgakis
Publié dans: Circulation, Numéro 149, 2025, ISSN 0009-7322
Éditeur: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1161/CIRCULATIONAHA.123.064974

Tobacco smoking is associated with sex- and plaque-type specific upregulation of CRLF1 in atherosclerotic lesions

Auteurs: Tian Lan, Kaylin C.A. Palm, Luka Hoeben, Ernest Diez Benavente, R. Noah Perry, Mete Civelek, Dominique P.V. de Kleijn, Hester M. den Ruijter, Gerard Pasterkamp, Michal Mokry
Publié dans: Atherosclerosis, Numéro 397, 2024, ISSN 0021-9150
Éditeur: Elsevier BV
DOI: 10.1016/j.atherosclerosis.2024.118554