MultiomIcs based Risk stratification of Atherosclerotic CardiovascuLar disEase

Informazioni relative al progetto

MIRACLE

ID dell’accordo di sovvenzione: 101115381

DOI

10.3030/101115381

Data della firma CE 14 Giugno 2023

Data di avvio 1 Ottobre 2023

Data di completamento 30 Settembre 2027

Finanziato da

• The European Innovation Council (EIC)

Costo totale

€ 4 599 866,25

Contributo UE

€ 4 599 866,25

Coordinato da

ITA-SUOMEN YLIOPISTO
Finland

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (3)

General Assembly Meeting-1

Online meeting with Partner PIs. Project planning and tracking report (minutes/PPTs) (Tasks 5.1-2)

Website and project logo

Website and project logo information with social media links (Task 5.3)

Sex-stratified clusters of plaques

Define and report sex specific plaque clusters (Task 2.1)

Data Management Plan (1)

Data Management plan

Describes the data management life cycle (Task 5.1)

Pubblicazioni

Peer reviewed articles (15)

Arteriosclerosis, Thrombosis, and Vascular Biology

Autori: Ilakya Selvarajan; Miika Kiema; Ru-Ting Huang; Jin Li; Jiayu Zhu; Petri Pölönen; Tiit Örd; Kadri Õunap; Mehvash Godiwala; Anna Kathryn Golebiewski; Aarthi Ravindran; Kiira Mäklin; Anu Toropainen; Lindsey K. Stolze; Maximiliano Arce; Peetra U. Magnusson; Stephen White; Casey E. Romanoski; Merja Heinäniemi; Johanna P. Laakkonen; Yun Fang; Minna U. Kaikkonen
Pubblicato in: Arteriosclerosis, Thrombosis, and Vascular Biology, Numero 44, 2024, ISSN 1079-5642
Editore: American Heart Association
DOI: 10.1161/ATVBAHA.123.318964

Predicting the genetic component of gene expression using gene regulatory networks

Autori: Gutama Ibrahim Mohammad; Tom Michoel
Pubblicato in: Bioinformatics Advances, 2024, ISSN 2635-0041
Editore: Oxford University Press
DOI: 10.48550/ARXIV.2408.08530

Clonal haematopoiesis of indeterminate potential and mortality in coronary artery disease

Autori: Moritz von Scheidt, Shaunak S Adkar, Johannes Krefting, Gregor Hoermann, Manja Meggendorfer, Sabine Bauer, Shaneice Mitchell, Irina Pugach, Christian Friess, Angela Ma, Ke Hao, Sophia Steigerwald, Maria Wahle, Thorsten Kessler, Marius Schwab, Felix Voll, Michal Mokry, Charalampos Sofokleous, Kaylin C A Palm, Dario Bongiovanni, Julia Fleig, Lilith Oldenbuettel, Zhifen Chen, Judith S Hecker, Florian Bassermann, Lars Maegdefessel, Matthias Graw, Arno Ruusalepp, Ingo Hilgendorf, Florian Leuschner, Hendrik B Sager, J Brett Heimlich, Wolfgang Koenig, Sebastian Cremer, David M Leistner, Wesley T Abplanalp, Stefanie Dimmeler, Andreas M Zeiher, Sander W van der Laan, Gerard Pasterkamp, Christian Braun, Siddhartha Jaiswal, Jason C Kovacic, Wolfgang Kern, Claudia Haferlach, Matthias Mann, Salvatore Cassese, Adnan Kastrati, Torsten Haferlach, Nicholas J Leeper, Johan L M Björkegren, Heribert Schunkert
Pubblicato in: European Heart Journal, Numero 47, 2026, ISSN 0195-668X
Editore: Oxford University Press (OUP)
DOI: 10.1093/EURHEARTJ/EHAF602

Evidence of survival bias in the association between APOE-Є4 and age at ischemic stroke onset

Autori: Joanna von Berg, Patrick F. McArdle, Paavo Häppölä, Jeffrey Haessler, Charles Kooperberg, Robin Lemmens, Alessandro Pezzini, Vincent Thijs, Sara L. Pulit, Steven J. Kittner, Braxton D. Mitchell, Jeroen de Ridder, Sander W. van der Laan
Pubblicato in: Frontiers in Genetics, Numero 15, 2024, ISSN 1664-8021
Editore: Frontiers Media SA
DOI: 10.3389/fgene.2024.1392061

Prediction of causal genes at GWAS loci with pleiotropic gene regulatory effects using sets of correlated instrumental variables

Autori: Mariyam Khan; Adriaan-Alexander Ludl; Sean Bankier; Johan L. M. Björkegren; Tom Michoel
Pubblicato in: PLOS Genetics, 2024, ISSN 1553-7404
Editore: Public Library of Science (PLOS)
DOI: 10.48550/ARXIV.2401.06261

Single-Cell Gene-Regulatory Networks of Advanced Symptomatic Atherosclerosis

Autori: Giuseppe Mocci, Katyayani Sukhavasi, Tiit Örd, Sean Bankier, Prosanta Singha, Uma Thanigai Arasu, Olayinka Oluwasegun Agbabiaje, Petri Mäkinen, Lijiang Ma, Chani J. Hodonsky, Redouane Aherrahrou, Lars Muhl, Jianping Liu, Sonja Gustafsson, Byambajav Byandelger, Ying Wang, Simon Koplev, Urban Lendahl, Gary K. Owens, Nicholas J. Leeper, Gerard Pasterkamp, Michael Vanlandewijck, Tom Michoel, Arno Ruusalepp, Ke Hao, Seppo Ylä-Herttuala, Marika Väli, Heli Järve, Michal Mokry, Mete Civelek, Clint J. Miller, Jason C. Kovacic, Minna U. Kaikkonen, Christer Betsholtz, Johan L.M. Björkegren
Pubblicato in: Circulation Research, Numero 134, 2024, ISSN 0009-7330
Editore: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1161/CIRCRESAHA.123.323184

Integration of a polygenic score into guideline-recommended prediction of cardiovascular disease

Autori: Ling Li, Shichao Pang, Fabian Starnecker, Bertram Mueller-Myhsok, Heribert Schunkert
Pubblicato in: European Heart Journal, Numero 45, 2024, ISSN 0195-668X
Editore: Oxford University Press (OUP)
DOI: 10.1093/eurheartj/ehae048

Circulating causal protein networks linked to future risk of myocardial infarction

Autori: Sean Bankier, Valborg Gudmundsdottir, Thorarinn Jonmundsson, Heida Bjarnadottir, Joseph Loureiro, Lingfei Wang, Elísabet A. Frick, Nancy Finkel, Anthony P. Orth, Thor Aspelund, Lenore J. Launer, Johan L. M. Björkegren, Lori L. Jennings, John R. Lamb, Vilmundur Gudnason, Tom Michoel, Valur Emilsson
Pubblicato in: Nature Communications, Numero 17, 2026, ISSN 2041-1723
Editore: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-67135-3

Clinical utility and implementation of polygenic risk scores for predicting cardiovascular disease

Autori: Heribert Schunkert, Emanuele Di Angelantonio, Michael Inouye, Riyaz S Patel, Samuli Ripatti, Elisabeth Widen, Saskia C Sanderson, Juan Pablo Kaski, John W McEvoy, Panos Vardas, Angela Wood, Victor Aboyans, Vassilios S Vassiliou, Frank L J Visseren, Luis R Lopes, Perry Elliott, Maryam Kavousi
Pubblicato in: European Heart Journal, Numero 46, 2025, ISSN 0195-668X
Editore: Oxford University Press (OUP)
DOI: 10.1093/EURHEARTJ/EHAE649

Single-cell RNA sequencing reveals sex differences in the subcellular composition and associated gene-regulatory network activity of human carotid plaques

Autori: Katyayani Sukhavasi; Giuseppe Mocci; Lijiang Ma; Chani J. Hodonsky; Ernest Diez Benevante; Lars Muhl; Jianping Liu; Sonja Gustafsson; Byambajav Buyandelger; Simon Koplev; Urban Lendahl; Michael Vanlandewijck; Prosanta Singha; Tiit Örd; Mustafa Beter; Ilakya Selvarajan; Johanna P. Laakkonen; Marika Väli; Hester M. den Ruijter; Mete Civelek; Ke Hao; Arno Ruusalepp; Christer Betsholtz; Heli Järve; Jason C. Kovacic; Clint L. Miller; Casey Romanoski; Minna U. Kaikkonen; Johan L. M. Björkegren
Pubblicato in: Nature Cardiovascular Research, 2025, ISSN 2731-0590
Editore: Springer Nature
DOI: 10.1038/S44161-025-00628-Y

Proteomics of mouse brain endothelium uncovers dysregulation of vesicular transport pathways during aging

Autori: Katalin Todorov-Völgyi; Judit González-Gallego; Stephan A. Müller; Nathalie Beaufort; Rainer Malik; Martina Schifferer; Mihail Ivilinov Todorov; Dennis Crusius; Sophie Robinson; Andree Schmidt; Jakob Körbelin; Florence Bareyre; Ali Ertürk; Christian Haass; Mikael Simons; Dominik Paquet; Stefan F. Lichtenthaler; Martin Dichgans
Pubblicato in: Nature Aging, 2024, ISSN 2662-8465
Editore: Nature
DOI: 10.1038/S43587-024-00598-Z

The Effects of FABP4 on Cardiovascular Disease in the Aging Population

Autori: Ellen M. van der Ark-Vonk, Mike V. Puijk, Gerard Pasterkamp, Sander W. van der Laan
Pubblicato in: Current Atherosclerosis Reports, Numero 26, 2024, ISSN 1523-3804
Editore: Springer Science and Business Media LLC
DOI: 10.1007/s11883-024-01196-5

Genetic variation drives differences in obesity-related gene regulation

Autori: Minna U. Kaikkonen
Pubblicato in: Trends in Genetics, Numero 40, 2024, ISSN 0168-9525
Editore: Elsevier BV
DOI: 10.1016/j.tig.2024.02.009

Proteogenomic Data Integration Reveals CXCL10 as a Potentially Downstream Causal Mediator for IL-6 Signaling on Atherosclerosis

Autori: Savvina Prapiadou, Luka Živković, Barbara Thorand, Marc J. George, Sander W. van der Laan, Rainer Malik, Christian Herder, Wolfgang Koenig, Thor Ueland, Ola Kleveland, Pål Aukrust, Lars Gullestad, Jürgen Bernhagen, Gerard Pasterkamp, Annette Peters, Aroon D. Hingorani, Jonathan Rosand, Martin Dichgans, Christopher D. Anderson, Marios K. Georgakis
Pubblicato in: Circulation, Numero 149, 2025, ISSN 0009-7322
Editore: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1161/CIRCULATIONAHA.123.064974

Tobacco smoking is associated with sex- and plaque-type specific upregulation of CRLF1 in atherosclerotic lesions

Autori: Tian Lan, Kaylin C.A. Palm, Luka Hoeben, Ernest Diez Benavente, R. Noah Perry, Mete Civelek, Dominique P.V. de Kleijn, Hester M. den Ruijter, Gerard Pasterkamp, Michal Mokry
Pubblicato in: Atherosclerosis, Numero 397, 2024, ISSN 0021-9150
Editore: Elsevier BV
DOI: 10.1016/j.atherosclerosis.2024.118554