MultiomIcs based Risk stratification of Atherosclerotic CardiovascuLar disEase

Información del proyecto

MIRACLE

Identificador del acuerdo de subvención: 101115381

DOI

10.3030/101115381

Fecha de la firma de la CE 14 Junio 2023

Fecha de inicio 1 Octubre 2023

Fecha de finalización 30 Septiembre 2027

Financiado con arreglo a

• The European Innovation Council (EIC)

Coste total

€ 4 599 866,25

Aportación de la UE

€ 4 599 866,25

Coordinado por

ITA-SUOMEN YLIOPISTO
Finland

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (3)

General Assembly Meeting-1

Online meeting with Partner PIs. Project planning and tracking report (minutes/PPTs) (Tasks 5.1-2)

Website and project logo

Website and project logo information with social media links (Task 5.3)

Sex-stratified clusters of plaques

Define and report sex specific plaque clusters (Task 2.1)

Data Management Plan (1)

Data Management plan

Describes the data management life cycle (Task 5.1)

Publicaciones

Peer reviewed articles (15)

Arteriosclerosis, Thrombosis, and Vascular Biology

Autores: Ilakya Selvarajan; Miika Kiema; Ru-Ting Huang; Jin Li; Jiayu Zhu; Petri Pölönen; Tiit Örd; Kadri Õunap; Mehvash Godiwala; Anna Kathryn Golebiewski; Aarthi Ravindran; Kiira Mäklin; Anu Toropainen; Lindsey K. Stolze; Maximiliano Arce; Peetra U. Magnusson; Stephen White; Casey E. Romanoski; Merja Heinäniemi; Johanna P. Laakkonen; Yun Fang; Minna U. Kaikkonen
Publicado en: Arteriosclerosis, Thrombosis, and Vascular Biology, Edición 44, 2024, ISSN 1079-5642
Editor: American Heart Association
DOI: 10.1161/ATVBAHA.123.318964

Predicting the genetic component of gene expression using gene regulatory networks

Autores: Gutama Ibrahim Mohammad; Tom Michoel
Publicado en: Bioinformatics Advances, 2024, ISSN 2635-0041
Editor: Oxford University Press
DOI: 10.48550/ARXIV.2408.08530

Clonal haematopoiesis of indeterminate potential and mortality in coronary artery disease

Autores: Moritz von Scheidt, Shaunak S Adkar, Johannes Krefting, Gregor Hoermann, Manja Meggendorfer, Sabine Bauer, Shaneice Mitchell, Irina Pugach, Christian Friess, Angela Ma, Ke Hao, Sophia Steigerwald, Maria Wahle, Thorsten Kessler, Marius Schwab, Felix Voll, Michal Mokry, Charalampos Sofokleous, Kaylin C A Palm, Dario Bongiovanni, Julia Fleig, Lilith Oldenbuettel, Zhifen Chen, Judith S Hecker, Florian Bassermann, Lars Maegdefessel, Matthias Graw, Arno Ruusalepp, Ingo Hilgendorf, Florian Leuschner, Hendrik B Sager, J Brett Heimlich, Wolfgang Koenig, Sebastian Cremer, David M Leistner, Wesley T Abplanalp, Stefanie Dimmeler, Andreas M Zeiher, Sander W van der Laan, Gerard Pasterkamp, Christian Braun, Siddhartha Jaiswal, Jason C Kovacic, Wolfgang Kern, Claudia Haferlach, Matthias Mann, Salvatore Cassese, Adnan Kastrati, Torsten Haferlach, Nicholas J Leeper, Johan L M Björkegren, Heribert Schunkert
Publicado en: European Heart Journal, Edición 47, 2026, ISSN 0195-668X
Editor: Oxford University Press (OUP)
DOI: 10.1093/EURHEARTJ/EHAF602

Evidence of survival bias in the association between APOE-Є4 and age at ischemic stroke onset

Autores: Joanna von Berg, Patrick F. McArdle, Paavo Häppölä, Jeffrey Haessler, Charles Kooperberg, Robin Lemmens, Alessandro Pezzini, Vincent Thijs, Sara L. Pulit, Steven J. Kittner, Braxton D. Mitchell, Jeroen de Ridder, Sander W. van der Laan
Publicado en: Frontiers in Genetics, Edición 15, 2024, ISSN 1664-8021
Editor: Frontiers Media SA
DOI: 10.3389/fgene.2024.1392061

Prediction of causal genes at GWAS loci with pleiotropic gene regulatory effects using sets of correlated instrumental variables

Autores: Mariyam Khan; Adriaan-Alexander Ludl; Sean Bankier; Johan L. M. Björkegren; Tom Michoel
Publicado en: PLOS Genetics, 2024, ISSN 1553-7404
Editor: Public Library of Science (PLOS)
DOI: 10.48550/ARXIV.2401.06261

Single-Cell Gene-Regulatory Networks of Advanced Symptomatic Atherosclerosis

Autores: Giuseppe Mocci, Katyayani Sukhavasi, Tiit Örd, Sean Bankier, Prosanta Singha, Uma Thanigai Arasu, Olayinka Oluwasegun Agbabiaje, Petri Mäkinen, Lijiang Ma, Chani J. Hodonsky, Redouane Aherrahrou, Lars Muhl, Jianping Liu, Sonja Gustafsson, Byambajav Byandelger, Ying Wang, Simon Koplev, Urban Lendahl, Gary K. Owens, Nicholas J. Leeper, Gerard Pasterkamp, Michael Vanlandewijck, Tom Michoel, Arno Ruusalepp, Ke Hao, Seppo Ylä-Herttuala, Marika Väli, Heli Järve, Michal Mokry, Mete Civelek, Clint J. Miller, Jason C. Kovacic, Minna U. Kaikkonen, Christer Betsholtz, Johan L.M. Björkegren
Publicado en: Circulation Research, Edición 134, 2024, ISSN 0009-7330
Editor: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1161/CIRCRESAHA.123.323184

Integration of a polygenic score into guideline-recommended prediction of cardiovascular disease

Autores: Ling Li, Shichao Pang, Fabian Starnecker, Bertram Mueller-Myhsok, Heribert Schunkert
Publicado en: European Heart Journal, Edición 45, 2024, ISSN 0195-668X
Editor: Oxford University Press (OUP)
DOI: 10.1093/eurheartj/ehae048

Circulating causal protein networks linked to future risk of myocardial infarction

Autores: Sean Bankier, Valborg Gudmundsdottir, Thorarinn Jonmundsson, Heida Bjarnadottir, Joseph Loureiro, Lingfei Wang, Elísabet A. Frick, Nancy Finkel, Anthony P. Orth, Thor Aspelund, Lenore J. Launer, Johan L. M. Björkegren, Lori L. Jennings, John R. Lamb, Vilmundur Gudnason, Tom Michoel, Valur Emilsson
Publicado en: Nature Communications, Edición 17, 2026, ISSN 2041-1723
Editor: Springer Science and Business Media LLC
DOI: 10.1038/S41467-025-67135-3

Clinical utility and implementation of polygenic risk scores for predicting cardiovascular disease

Autores: Heribert Schunkert, Emanuele Di Angelantonio, Michael Inouye, Riyaz S Patel, Samuli Ripatti, Elisabeth Widen, Saskia C Sanderson, Juan Pablo Kaski, John W McEvoy, Panos Vardas, Angela Wood, Victor Aboyans, Vassilios S Vassiliou, Frank L J Visseren, Luis R Lopes, Perry Elliott, Maryam Kavousi
Publicado en: European Heart Journal, Edición 46, 2025, ISSN 0195-668X
Editor: Oxford University Press (OUP)
DOI: 10.1093/EURHEARTJ/EHAE649

Single-cell RNA sequencing reveals sex differences in the subcellular composition and associated gene-regulatory network activity of human carotid plaques

Autores: Katyayani Sukhavasi; Giuseppe Mocci; Lijiang Ma; Chani J. Hodonsky; Ernest Diez Benevante; Lars Muhl; Jianping Liu; Sonja Gustafsson; Byambajav Buyandelger; Simon Koplev; Urban Lendahl; Michael Vanlandewijck; Prosanta Singha; Tiit Örd; Mustafa Beter; Ilakya Selvarajan; Johanna P. Laakkonen; Marika Väli; Hester M. den Ruijter; Mete Civelek; Ke Hao; Arno Ruusalepp; Christer Betsholtz; Heli Järve; Jason C. Kovacic; Clint L. Miller; Casey Romanoski; Minna U. Kaikkonen; Johan L. M. Björkegren
Publicado en: Nature Cardiovascular Research, 2025, ISSN 2731-0590
Editor: Springer Nature
DOI: 10.1038/S44161-025-00628-Y

Proteomics of mouse brain endothelium uncovers dysregulation of vesicular transport pathways during aging

Autores: Katalin Todorov-Völgyi; Judit González-Gallego; Stephan A. Müller; Nathalie Beaufort; Rainer Malik; Martina Schifferer; Mihail Ivilinov Todorov; Dennis Crusius; Sophie Robinson; Andree Schmidt; Jakob Körbelin; Florence Bareyre; Ali Ertürk; Christian Haass; Mikael Simons; Dominik Paquet; Stefan F. Lichtenthaler; Martin Dichgans
Publicado en: Nature Aging, 2024, ISSN 2662-8465
Editor: Nature
DOI: 10.1038/S43587-024-00598-Z

The Effects of FABP4 on Cardiovascular Disease in the Aging Population

Autores: Ellen M. van der Ark-Vonk, Mike V. Puijk, Gerard Pasterkamp, Sander W. van der Laan
Publicado en: Current Atherosclerosis Reports, Edición 26, 2024, ISSN 1523-3804
Editor: Springer Science and Business Media LLC
DOI: 10.1007/s11883-024-01196-5

Genetic variation drives differences in obesity-related gene regulation

Autores: Minna U. Kaikkonen
Publicado en: Trends in Genetics, Edición 40, 2024, ISSN 0168-9525
Editor: Elsevier BV
DOI: 10.1016/j.tig.2024.02.009

Proteogenomic Data Integration Reveals CXCL10 as a Potentially Downstream Causal Mediator for IL-6 Signaling on Atherosclerosis

Autores: Savvina Prapiadou, Luka Živković, Barbara Thorand, Marc J. George, Sander W. van der Laan, Rainer Malik, Christian Herder, Wolfgang Koenig, Thor Ueland, Ola Kleveland, Pål Aukrust, Lars Gullestad, Jürgen Bernhagen, Gerard Pasterkamp, Annette Peters, Aroon D. Hingorani, Jonathan Rosand, Martin Dichgans, Christopher D. Anderson, Marios K. Georgakis
Publicado en: Circulation, Edición 149, 2025, ISSN 0009-7322
Editor: Ovid Technologies (Wolters Kluwer Health)
DOI: 10.1161/CIRCULATIONAHA.123.064974

Tobacco smoking is associated with sex- and plaque-type specific upregulation of CRLF1 in atherosclerotic lesions

Autores: Tian Lan, Kaylin C.A. Palm, Luka Hoeben, Ernest Diez Benavente, R. Noah Perry, Mete Civelek, Dominique P.V. de Kleijn, Hester M. den Ruijter, Gerard Pasterkamp, Michal Mokry
Publicado en: Atherosclerosis, Edición 397, 2024, ISSN 0021-9150
Editor: Elsevier BV
DOI: 10.1016/j.atherosclerosis.2024.118554