Objective
Despite advances in clinical care, heart failure consequent to myocardial infarction remains a leading cause of mortality worldwide. Absence of cardiac regeneration post-infarction is mostly explained by the reduced mitotic potential of adult cardiomyocytes, that, in comparison with their embryonic counterparts, have an accumulation of morphological, metabolic and biochemical adaptations that render them recalcitrant to proliferation. Devising tools to precisely control the maturational status of cardiomyocytes would enable novel therapies for cardiac regeneration, either by stimulating cell cycle reentry of pre-existing cardiomyocytes, or enhancing the maturational status of cardiomyocytes derived from induced pluripotent stem cells for cell therapy. Novel.CaRe will explore the therapeutic potential of micropeptides, a novel class of proteins that, despite their small size, can play major cellular roles. Based on extensive preliminary work, I propose an ambitious interdisciplinary research program bridging advanced omics, animal models, human samples, bioinformatics, cellular phenotyping and innovative strategies for gene therapy. We will apply new translatomics and proteomics approaches to identify micropeptides conserved across species and modulated during cardiomyocyte maturation, define their cellular functions and test their potential to induce proliferation of cell cycle withdrawn cardiomyocytes or enhance maturation of stem cell-derived cardiomyocytes. In a high-risk, high-gain part of the project, we will develop a novel approach for gene therapy enabling time-controlled, cardiomyocyte-specific expression of a combination of micropeptides normally expressed by embryonic cardiomyocytes and assess if this strategy successfully promotes regeneration of the adult heart post-injury. In conclusion, Novel.CaRe will generate new resources, technology and knowledge, pushing beyond the state-of-the-art in the fields of molecular cardiology and cardiac regeneration.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- social sciences sociology demography mortality
- medical and health sciences clinical medicine cardiology
You need to log in or register to use this function
We are sorry... an unexpected error occurred during execution.
You need to be authenticated. Your session might have expired.
Thank you for your feedback. You will soon receive an email to confirm the submission. If you have selected to be notified about the reporting status, you will also be contacted when the reporting status will change.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
HORIZON.1.1 - European Research Council (ERC)
MAIN PROGRAMME
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-ERC - HORIZON ERC Grants
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2023-STG
See all projects funded under this callHost institution
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
20122 Milano
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.