Project description
Understanding the endothelial cell’s role in ageing at the nanoscale
Our understanding of endothelial cells (ECs) and their crucial role in the transfer and clearance of metabolites and pharmaceuticals to vital organs, especially how ECs change with ageing, is limited at the nanoscale. Current optical nanoscopes are slow and can only be used on isolated, typically fixed (i.e. dead) cells. Additionally, newcomers to the field must acquaint themselves with potential issues such as image reconstruction-related artefacts. The EU-funded ImAge-D project aims to remove these limitations by training 10 doctoral candidates in high-speed, high-resolution biomedical imaging tools. The project will study living ECs and their changes with ageing, focusing on physics and biomedicine concepts/skills in super-resolution imaging, analytical image reconstruction and optical micro-manipulation.
Objective
ImAge-D will train a new generation of Doctoral Candidates (DCs) in the development and application of newly developed high speed and high-resolution imaging tools in biomedical research. The ten DCs will be cross-pollinated with concepts and skills in physics and biomedicine, in particular in super-resolution imaging, analytical image reconstruction, and optical micro-manipulation methods. These skills will be applied to reveal for the first time the functionality and morphology (below the diffraction limit of light) of living endothelial cells (EC) that present the main barrier between the blood/lymph and all organs and tissues, and how these vital cells change with ageing. Very little is known at the nanoscale about extremely important physiological functions of EC and their role in the transfer and/or clearance of metabolites and pharmaceuticals to vital organs, and how EC change with ageing. The current generation of optical nanoscopes, however, is rather slow and can only be applied to isolated, typically fixed (i.e. dead) cells rather than biomedically relevant tissues. Also, newcomers to the field need to familiarize themselves with a whole new set of potential problems that might arise in the use of optical nanoscopy, such as image reconstruction- related artifacts to name just one example.This is an area of research where European enterprises are very active. Excellent training in new scientific and complementary skills, combined with international and intersectoral work experience, will instill an innovative, creative and entrepreneurial mind-set in ImAge-D's DCs, maximising economic benefits based on scientific discoveries. These specialised, highly trained, and mobile DCs will have greatly enhanced career prospects. The training in novel physical methods with highly relevant experience in the biomedical sciences will allow them to confidently navigate at the interface of academic, clinical and private sector research.
Fields of science
Keywords
Programme(s)
- HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA) Main Programme
Funding Scheme
HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral NetworksCoordinator
9019 Tromso
Norway