Innovative Applications of Extracorporeal Photopheresis in Solid Organ Transplantation

Informazioni relative al progetto

exTra

ID dell’accordo di sovvenzione: 101119855

DOI

10.3030/101119855

Data della firma CE 13 Luglio 2023

Data di avvio 1 Settembre 2023

Data di completamento 31 Agosto 2027

Finanziato da

• Marie Skłodowska-Curie Actions (MSCA)

Costo totale

Nessun dato

Contributo UE

€ 2 613 103,20

Coordinato da

KLINIKUM DER UNIVERSITAET REGENSBURG
Germany

Periodic Reporting for period 1 - exTra (Innovative Applications of Extracorporeal Photopheresis in Solid Organ Transplantation)

Periodo di rendicontazione: 2023-09-01 al 2025-08-31

Sintesi del contesto e degli obiettivi generali del progetto

Organ transplantation saves and transforms lives, but long-term success remains limited by immune rejection and the side effects of lifelong immunosuppressive drugs. While short-term outcomes have improved greatly, many patients still experience gradual loss of organ function, chronic inflammation, or serious complications caused by standard therapies. Therefore, there is an urgent need for innovative, patient-tailored approaches that can better control the immune system while reducing treatment burden.
The EU-funded doctoral network exTra (Innovative Applications of Extracorporeal Photopheresis in Solid Organ Transplantation) addresses this challenge by exploring the potential of extracorporeal photopheresis (ECP), a personalised immune-modulating therapy already used in selected transplant settings. exTra aims to deepen understanding of how ECP works, identify where it could be most beneficial, and lay the foundations for its wider and more effective use across different types of organ transplantation.
Beyond its scientific goals, the exTra network is a highly integrated European training network. It brings together universities, hospitals, research institutes, industry partners, and clinicians to train a new generation of doctoral researchers with the interdisciplinary skills needed to translate complex biomedical research into real-world clinical impact.

Lavoro eseguito dall’inizio del progetto fino alla fine del periodo coperto dalla relazione e principali risultati finora ottenuti

exTra combines basic research, translational studies, and clinical insight across several complementary research themes. Researchers within the network investigate how ECP influences immune regulation, antibody-mediated responses, tissue repair, and treatment optimisation in different transplant contexts, including kidney, liver, lung, and heart transplantation.
A major achievement of the project is the coordinated investigation of ECP from multiple perspectives. Experimental models, patient samples, advanced molecular analyses, and computational approaches are used in parallel, allowing discoveries in one area to inform progress in others. This collaborative structure ensures that knowledge is shared efficiently across institutions and disciplines.
At the same time, exTra places strong emphasis on doctoral training. Doctoral candidates receive joint supervision, participate in secondments across Europe, and engage in network-wide courses on topics such as data management, reproducible science, regulatory pathways, ethics, and science communication. Many have already contributed to peer-reviewed publications and international conferences, demonstrating both scientific progress and professional development.

Progressi oltre lo stato dell’arte e potenziale impatto previsto (incluso l’impatto socioeconomico e le implicazioni sociali più ampie del progetto fino ad ora)

Rather than focusing on a single mechanism or disease, exTra advances the field by taking a broad view of immune modulation in transplantation. The project moves beyond “one-size-fits-all” immunosuppression by exploring how therapies like ECP may promote immune balance, support tissue healing, and reduce harmful immune responses without generally suppressing immunity.
exTra also contributes methodological advances, including improved experimental models, harmonised laboratory protocols, and innovative approaches to immune monitoring. These developments help create a more robust and reproducible framework for studying complex immune therapies.
Importantly, the project strengthens the bridge between discovery science and clinical application. By integrating academic research with industrial expertise and clinical practice, exTra helps ensure that new insights are compatible with real-world healthcare needs, regulatory requirements, and future innovation pathways.

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