Supple Graphene Bio-Platform for point-of-care early detection and monitoring of Alzheimer’s Disease

Project Information

2D-BioPAD

Grant agreement ID: 101120706

DOI

10.3030/101120706

EC signature date 29 June 2023

Start date 1 October 2023

End date 30 September 2027

Funded under

• Digital, Industry and Space

Total cost

€ 5 957 997,50

EU contribution

€ 5 957 949,50

Coordinated by

UNIVERZITA PALACKEHO V OLOMOUCI
Czechia

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (5)

Clinical Pilot Studies Initiation Package and Ethics check

Studies registration Information, including approved protocol and other regulatory and ethics documentation. Ethics check will be carried out by the experts nominated by EC.

Conjugated MNPs/Aptamers Binding to AD Biomarkers evaluation, Version 1

Evaluation results of the binding affinity and specificity to AD biomarkers after optimised functionalisation.

MCI to AD Biomarker Deep Dive Analysis for Early Diagnosis

Detailed mapping of End-users’ Needs, Disease Challenges, and Requirements

System Architecture, Version 1

High-level system architecture and evaluation use cases design

Data Management Plan, Version 1

Procedures set for data collection, processing, monitoring, dissemination, and ethics compliance.

Publications

Conference proceedings (9)

Development of aptamer-biofunctionalized magnetic nanoparticles for the detection of Alzheimer's disease biomarkers

Author(s): Katsipis, Georgios; Tzekaki, Eleni; Makridis, Antonios; Kazeli, Konstantina; Angelakeris, Makis; Pantazaki, Anastasia
Published in: 14th PICAD-6th MeCoND Proceedings, 2025
Publisher: GAADRD
DOI: 10.5281/ZENODO.14975545

Socio-economic and clinical needs and challenges for early detection and progression monitoring of Alzheimer's disease in primary healthcare

Author(s): Juel Holst, Gitte; Koukoura, Angeliki; Antonopoulou, Kyriaki; Tsolakis, Apostolos C.; Roma-Athanasiadou, Elli; Solomon, Alina; Tsolaki, Magda; Froelich, Lutz; Tsolaki, Anthoula; Issakainen, Mervi; Mäki-Petäjä-Leinonen, Anna; Vassiliadis, Efstathios
Published in: 34th Alzheimer Europe Conference, 2024
Publisher: EVNIA
DOI: 10.5281/ZENODO.14936477

Functional coatings of magnetic nanoparticles for Alzheimer's disease applications

Author(s): Kazeli, Konstantina; Malkaki, Foteini; Makridis, Antonios; Anastasiou, Anna; Tsamesidis, Ioannis; Malletzidou, Lamprini; Kontonasaki, Eleana; Lymperaki, Evgenia;
Published in: 2025
Publisher: GAADRD
DOI: 10.5281/ZENODO.14975567

Clinical validation of a novel point-of-care diagnostic aid for early detection and monitoring of Alzheimer's Disease The Clinical protocol of 2D-BioPAD, a Horizon Europe Framework Programme

Author(s): Tsolaki, Anthoula; Solomon, Alina; Froelich, Lutz; Juel Holst, Gitte; Tsolaki, Magda
Published in: 14th PICAD-6th MeCoND Proceedings, 2025
Publisher: GAADRD
DOI: 10.5281/ZENODO.14975403

Silver Covalently Bound to Cyanographene Overcomes Bacterial Resistance to Silver Nanoparticles and Antibiotics

Author(s): Panáček, David; Hochvaldova, Lucie; Bakandritsos, Aristides; Malina, Tomáš; Langer, Michal; Bělka, Jan; Martincová, Jana; Večeřová, Renata; Lazar, Petr; Poláková, Kateřina; Kolařík, Jan; Válková, Lucie; Kolář, Milan; Otyepka, Michal; Panacek, Ales; Zboril
Published in: Graphene Week 2024, 2024
Publisher: UP-CATRIN
DOI: 10.5281/ZENODO.14971534

Synthetic controls in nanoparticles for focusing and enhancing neurodegenerative signals

Author(s): Makridis, Antonios; Kazeli, Konstantina; Katsipis, Georgios; Tzekaki, Eleni; PANTAZAKI, Anastasia; ANGELAKERIS, MAKIS
Published in: 14th PICAD-6th MeCoND Proceedings, 2025
Publisher: GAADRD
DOI: 10.5281/ZENODO.14975466

A Gold-aptamer nanoconjugate for the detection of thrombin, a potential biomarker of AD

Author(s): Tzekaki, Eleni; Katsipis, Georgios; Kazeli, Konstantina; Makridis, Antonios; Angelakeris, Makis; Pantazaki, Anastasia
Published in: 14th PICAD-6th MeCoND Proceedings, 2025
Publisher: GAADRD
DOI: 10.5281/ZENODO.14975515

Advancing Clinical and Environmental Monitoring: Graphene-Enhanced Bioreceptor Integration

Author(s): Rossetti, Marianna; Alvarez Diduk, Ruslan; Bruno Darder; Maroli, Gabriel; Marques, Davi; de Amorim, Renê Santos; Liang, Yi-Fan; Ameda, Ana; Cenolli, Sadik; Kulla, Lueda; Broli, Nevila; Vasjari, Majlinda; Merkoçi, Arben
Published in: Graphene Week 2024, 2024
Publisher: ICN2
DOI: 10.5281/ZENODO.14974753

Socio-economic and clinical needs and challenges in early detection and progression monitoring of Alzheimer's Disease in primary healthcare in Greece

Author(s): PIkouli, Foteini Aikaterini; Juel Holst, Gitte; Koukoura, Angeliki; Antonopoulou, Kyriaki; Tsolaki, Magda
Published in: 14th PICAD-6th MeCoND Proceedings, 2025
Publisher: GAADRD
DOI: 10.5281/ZENODO.14975286

Peer reviewed articles (4)

Harnessing Bioluminescent Bacteria to Develop an Enzymatic-free Enzyme-linked immunosorbent assay for the Detection of Clinically Relevant Biomarkers

Author(s): Hu, Liming; Rossetti, Marianna; Bergua, José Francisco; Parolo, Claudio; Álvarez-Diduk, Ruslan; Rivas, Lourdes; Idili, Andrea; Merkoçi, Arben
Published in: ACS Applied Materials & Interfaces, 2024, ISSN 1944-8252
Publisher: ACS
DOI: 10.1021/ACSAMI.4C01744

Single Atom Engineered Antibiotics Overcome Bacterial Resistance

Author(s): David Panáček; Jan Belza; Lucie Hochvaldová; Zdeněk Baďura; Giorgio Zoppellaro; Martin Šrejber; Tomáš Malina; Veronika Šedajová; Markéta Paloncýová; Rostislav Langer; Lukáš Zdražil; Jianrong Zeng; Lina Li; En Zhao; Zupeng Chen; Zhiqiang Xiong; Ruibin Li; Aleš Panáček; Renata Večeřová; Pavla Kučová; Milan Kolář; Michal Otyepka; Aristides Bakandritsos; Radek Zbořil
Published in: Advanced Materials, 2024, ISSN 1521-4095
Publisher: Wiley
DOI: 10.1002/ADMA.202410652

Biosensors and Bioelectronics

Author(s): Calucho, Enric; Álvarez-Diduk, Ruslan; Piper, Andrew; Rossetti, Marianna; Nevanen, Tarja K.; Merkoçi, Arben
Published in: Biosensors and Bioelectronics, 2024, ISSN 0956-5663
Publisher: Elsevier
DOI: 10.1016/J.BIOS.2024.116315

MXenes in healthcare: synthesis, fundamentals and applications

Author(s): Zaheer Ud Din Babar; Vincenzo Iannotti; Giulio Rosati; Ayesha Zaheer; Raffaele Velotta; Bartolomeo Della Ventura; Ruslan Álvarez-Diduk; Arben Merkoçi
Published in: Chemical Society Reviews, 2025, ISSN 1460-4744
Publisher: The Royal Society of Chemistry
DOI: 10.1039/D3CS01024D