Supple Graphene Bio-Platform for point-of-care early detection and monitoring of Alzheimer’s Disease

Información del proyecto

2D-BioPAD

Identificador del acuerdo de subvención: 101120706

DOI

10.3030/101120706

Fecha de la firma de la CE 29 Junio 2023

Fecha de inicio 1 Octubre 2023

Fecha de finalización 30 Septiembre 2027

Financiado con arreglo a

• Digital, Industry and Space

Coste total

€ 5 957 997,50

Aportación de la UE

€ 5 957 949,50

Coordinado por

UNIVERZITA PALACKEHO V OLOMOUCI
Czechia

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Documents, reports (5)

Clinical Pilot Studies Initiation Package and Ethics check

Studies registration Information, including approved protocol and other regulatory and ethics documentation. Ethics check will be carried out by the experts nominated by EC.

Conjugated MNPs/Aptamers Binding to AD Biomarkers evaluation, Version 1

Evaluation results of the binding affinity and specificity to AD biomarkers after optimised functionalisation.

MCI to AD Biomarker Deep Dive Analysis for Early Diagnosis

Detailed mapping of End-users’ Needs, Disease Challenges, and Requirements

System Architecture, Version 1

High-level system architecture and evaluation use cases design

Data Management Plan, Version 1

Procedures set for data collection, processing, monitoring, dissemination, and ethics compliance.

Publicaciones

Conference proceedings (9)

Development of aptamer-biofunctionalized magnetic nanoparticles for the detection of Alzheimer's disease biomarkers

Autores: Katsipis, Georgios; Tzekaki, Eleni; Makridis, Antonios; Kazeli, Konstantina; Angelakeris, Makis; Pantazaki, Anastasia
Publicado en: 14th PICAD-6th MeCoND Proceedings, 2025
Editor: GAADRD
DOI: 10.5281/ZENODO.14975545

Socio-economic and clinical needs and challenges for early detection and progression monitoring of Alzheimer's disease in primary healthcare

Autores: Juel Holst, Gitte; Koukoura, Angeliki; Antonopoulou, Kyriaki; Tsolakis, Apostolos C.; Roma-Athanasiadou, Elli; Solomon, Alina; Tsolaki, Magda; Froelich, Lutz; Tsolaki, Anthoula; Issakainen, Mervi; Mäki-Petäjä-Leinonen, Anna; Vassiliadis, Efstathios
Publicado en: 34th Alzheimer Europe Conference, 2024
Editor: EVNIA
DOI: 10.5281/ZENODO.14936477

Functional coatings of magnetic nanoparticles for Alzheimer's disease applications

Autores: Kazeli, Konstantina; Malkaki, Foteini; Makridis, Antonios; Anastasiou, Anna; Tsamesidis, Ioannis; Malletzidou, Lamprini; Kontonasaki, Eleana; Lymperaki, Evgenia;
Publicado en: 2025
Editor: GAADRD
DOI: 10.5281/ZENODO.14975567

Clinical validation of a novel point-of-care diagnostic aid for early detection and monitoring of Alzheimer's Disease The Clinical protocol of 2D-BioPAD, a Horizon Europe Framework Programme

Autores: Tsolaki, Anthoula; Solomon, Alina; Froelich, Lutz; Juel Holst, Gitte; Tsolaki, Magda
Publicado en: 14th PICAD-6th MeCoND Proceedings, 2025
Editor: GAADRD
DOI: 10.5281/ZENODO.14975403

Silver Covalently Bound to Cyanographene Overcomes Bacterial Resistance to Silver Nanoparticles and Antibiotics

Autores: Panáček, David; Hochvaldova, Lucie; Bakandritsos, Aristides; Malina, Tomáš; Langer, Michal; Bělka, Jan; Martincová, Jana; Večeřová, Renata; Lazar, Petr; Poláková, Kateřina; Kolařík, Jan; Válková, Lucie; Kolář, Milan; Otyepka, Michal; Panacek, Ales; Zboril
Publicado en: Graphene Week 2024, 2024
Editor: UP-CATRIN
DOI: 10.5281/ZENODO.14971534

Synthetic controls in nanoparticles for focusing and enhancing neurodegenerative signals

Autores: Makridis, Antonios; Kazeli, Konstantina; Katsipis, Georgios; Tzekaki, Eleni; PANTAZAKI, Anastasia; ANGELAKERIS, MAKIS
Publicado en: 14th PICAD-6th MeCoND Proceedings, 2025
Editor: GAADRD
DOI: 10.5281/ZENODO.14975466

A Gold-aptamer nanoconjugate for the detection of thrombin, a potential biomarker of AD

Autores: Tzekaki, Eleni; Katsipis, Georgios; Kazeli, Konstantina; Makridis, Antonios; Angelakeris, Makis; Pantazaki, Anastasia
Publicado en: 14th PICAD-6th MeCoND Proceedings, 2025
Editor: GAADRD
DOI: 10.5281/ZENODO.14975515

Advancing Clinical and Environmental Monitoring: Graphene-Enhanced Bioreceptor Integration

Autores: Rossetti, Marianna; Alvarez Diduk, Ruslan; Bruno Darder; Maroli, Gabriel; Marques, Davi; de Amorim, Renê Santos; Liang, Yi-Fan; Ameda, Ana; Cenolli, Sadik; Kulla, Lueda; Broli, Nevila; Vasjari, Majlinda; Merkoçi, Arben
Publicado en: Graphene Week 2024, 2024
Editor: ICN2
DOI: 10.5281/ZENODO.14974753

Socio-economic and clinical needs and challenges in early detection and progression monitoring of Alzheimer's Disease in primary healthcare in Greece

Autores: PIkouli, Foteini Aikaterini; Juel Holst, Gitte; Koukoura, Angeliki; Antonopoulou, Kyriaki; Tsolaki, Magda
Publicado en: 14th PICAD-6th MeCoND Proceedings, 2025
Editor: GAADRD
DOI: 10.5281/ZENODO.14975286

Peer reviewed articles (4)

Harnessing Bioluminescent Bacteria to Develop an Enzymatic-free Enzyme-linked immunosorbent assay for the Detection of Clinically Relevant Biomarkers

Autores: Hu, Liming; Rossetti, Marianna; Bergua, José Francisco; Parolo, Claudio; Álvarez-Diduk, Ruslan; Rivas, Lourdes; Idili, Andrea; Merkoçi, Arben
Publicado en: ACS Applied Materials & Interfaces, 2024, ISSN 1944-8252
Editor: ACS
DOI: 10.1021/ACSAMI.4C01744

Single Atom Engineered Antibiotics Overcome Bacterial Resistance

Autores: David Panáček; Jan Belza; Lucie Hochvaldová; Zdeněk Baďura; Giorgio Zoppellaro; Martin Šrejber; Tomáš Malina; Veronika Šedajová; Markéta Paloncýová; Rostislav Langer; Lukáš Zdražil; Jianrong Zeng; Lina Li; En Zhao; Zupeng Chen; Zhiqiang Xiong; Ruibin Li; Aleš Panáček; Renata Večeřová; Pavla Kučová; Milan Kolář; Michal Otyepka; Aristides Bakandritsos; Radek Zbořil
Publicado en: Advanced Materials, 2024, ISSN 1521-4095
Editor: Wiley
DOI: 10.1002/ADMA.202410652

Biosensors and Bioelectronics

Autores: Calucho, Enric; Álvarez-Diduk, Ruslan; Piper, Andrew; Rossetti, Marianna; Nevanen, Tarja K.; Merkoçi, Arben
Publicado en: Biosensors and Bioelectronics, 2024, ISSN 0956-5663
Editor: Elsevier
DOI: 10.1016/J.BIOS.2024.116315

MXenes in healthcare: synthesis, fundamentals and applications

Autores: Zaheer Ud Din Babar; Vincenzo Iannotti; Giulio Rosati; Ayesha Zaheer; Raffaele Velotta; Bartolomeo Della Ventura; Ruslan Álvarez-Diduk; Arben Merkoçi
Publicado en: Chemical Society Reviews, 2025, ISSN 1460-4744
Editor: The Royal Society of Chemistry
DOI: 10.1039/D3CS01024D