Description du projet
Régénération osseuse de qualité après résection d’un cancer des os
Les procédures de référence actuelles pour le traitement des cancers des os qui affectent principalement les jeunes, tels que l’ostéosarcome et le sarcome d’Ewing, impliquent des implants en titane. Toutefois, elles ne permettent souvent qu’une reconstruction incomplète, entraînant des complications et impliquant de nouvelles opérations. Financé par le Conseil européen de la recherche, le projet BioBone propose une approche de pointe qui intègre des implants en titane poreux imprimés en 3D et des échafaudages bioactifs. Cette solution apporte un meilleur microenvironnement pour une régénération osseuse efficace après la résection de la tumeur. Après optimisation, les chercheurs testeront la biocompatibilité et le potentiel d’ostéointégration de cette solution in vivo. Envisagée comme une amélioration majeure des soins post-résection, cette nouvelle technologie devrait améliorer la qualité de vie des patients atteints de cancer des os.
Objectif
Osteosarcoma and Ewing sarcoma are the most common types of cancer in patients younger than 30 years. The gold standard treatment is bone tumor resection followed by reconstruction of the tissue, thereby allowing the salvage of the limb. Titanium and its alloys are mostly used in such orthopedic surgeries due to their biocompatibility and excellent mechanical properties. A novel, cutting-edge technology of patient-specific implants, 3-dimensional (3D) printed porous titanium implants, was recently introduced to clinical use. Yet, even several years after surgery, the resected section is not fully reconstructed, leading to further medical complications often requiring re-operations. A promising solution is the combination of titanium porous implants with bioactive scaffolds to support bone regeneration following tumor resection. Here, we aim to fabricate a 3D-printed porous titanium implant incorporated with patent-protected bioactive materials we have developed in the scope of the PersonalBone ERC-StG project to provide an optimal microenvironment for stimulating bone regeneration following bone tumor resection. For this purpose, we will optimize the formulation as well as the method of incorporation into 3D-printed titanium implants. The incorporated implants will be tested for biocompatibility and osteointegration in critical-size bone defect models in vivo. As we recently demonstrated for the novel materials, we will examine several success criteria, which will be refined according to input from orthopedic oncology surgeons who routinely perform tumor resections. This novel technology is envisioned to significantly advance the current treatments offered following bone resection, thereby considerably reducing the risk of further complications and offering a major improvement in the quality of life of patients recovering from bone cancer.
Champ scientifique
Mots‑clés
Programme(s)
- HORIZON.1.1 - European Research Council (ERC) Main Programme
Régime de financement
HORIZON-ERC-POC - HORIZON ERC Proof of Concept GrantsInstitution d’accueil
69978 Tel Aviv
Israël