Descripción del proyecto
Regeneración ósea eficaz tras la resección de un cáncer óseo
Los procedimientos de referencia actuales para tratar tumores óseos que afectan sobre todo a personas jóvenes, como el osteosarcoma y el sarcoma de Ewing, suponen el empleo de implantes de titanio. Sin embargo, estos conllevan a menudo una reconstrucción ósea incompleta, lo que provoca complicaciones y la necesidad de efectuar reintervenciones. En el proyecto BioBone, financiado por el Consejo Europeo de Investigación, se desarrollará un método de vanguardia que integra implantes de titanio poroso impresos en tres dimensiones con matrices bioactivas. La solución generada ofrece un microentorno mejorado para una regeneración ósea eficaz tras la resección tumoral. Tras la optimización, los investigadores probarán la biocompatibilidad y el potencial de osteointegración de esta solución «in vivo». Se prevé que esta novedosa tecnología, concebida como una mejora notable de los cuidados posteriores a la resección, mejore la calidad de vida de los enfermos de cáncer óseo.
Objetivo
Osteosarcoma and Ewing sarcoma are the most common types of cancer in patients younger than 30 years. The gold standard treatment is bone tumor resection followed by reconstruction of the tissue, thereby allowing the salvage of the limb. Titanium and its alloys are mostly used in such orthopedic surgeries due to their biocompatibility and excellent mechanical properties. A novel, cutting-edge technology of patient-specific implants, 3-dimensional (3D) printed porous titanium implants, was recently introduced to clinical use. Yet, even several years after surgery, the resected section is not fully reconstructed, leading to further medical complications often requiring re-operations. A promising solution is the combination of titanium porous implants with bioactive scaffolds to support bone regeneration following tumor resection. Here, we aim to fabricate a 3D-printed porous titanium implant incorporated with patent-protected bioactive materials we have developed in the scope of the PersonalBone ERC-StG project to provide an optimal microenvironment for stimulating bone regeneration following bone tumor resection. For this purpose, we will optimize the formulation as well as the method of incorporation into 3D-printed titanium implants. The incorporated implants will be tested for biocompatibility and osteointegration in critical-size bone defect models in vivo. As we recently demonstrated for the novel materials, we will examine several success criteria, which will be refined according to input from orthopedic oncology surgeons who routinely perform tumor resections. This novel technology is envisioned to significantly advance the current treatments offered following bone resection, thereby considerably reducing the risk of further complications and offering a major improvement in the quality of life of patients recovering from bone cancer.
Ámbito científico
Palabras clave
Programa(s)
- HORIZON.1.1 - European Research Council (ERC) Main Programme
Régimen de financiación
HORIZON-ERC-POC - HORIZON ERC Proof of Concept GrantsInstitución de acogida
69978 Tel Aviv
Israel