According to the International Energy Agency (IEA), electric motors (e-motors) consume more than 40% of electricity produced globally. The EU has set bold targets (regulation 2019/1781, 2nd phase effective from 01.07.2023) for increasing their efficiency and aiming to save 110TWh by 2030; this corresponds to 40 Mt of CO2 emissions per year with today’s electricity mix, which is equivalent to the electricity consumption of the Netherlands. E-motors are also the driving force behind Electric Vehicles (EVs), currently leading the global efforts for decarbonisation of the transportation sector; e-motor efficiency is crucial in extending EV mileage. Unfortunately, electrification of commercial or heavy-duty vehicles, earth-moving machines and aircrafts have to overcome, among other significant limitations (such efficient energy storage and battery weight, safety, limited availability of carbon-free fuels, cost etc), the technological barrier of excess e-motor heat generated during power-demanding operations. The long-term vision of E-COOL is to address this challenge via the development of a breakthrough direct-contact, spray cooling system. The envisioned technology will provide unprecedented cooling rates at the local temperature hot spots and result to an average 20% increase in e-motor efficiency compared to today’s state-of-the-art. In an equally important manner, the developed technology will also allow utilisation of e-motors in power-demanding applications, currently prohibited by the excess temperatures generated. These applications expand over the whole range of transportation sectors and, thus, they will contribute to EU’s decarbonization strategy, via significant additional energy and CO2 savings relative to the ones currently envisioned from existing regulations. Moreover, E-COOL aspires to achieve this technological breakthrough at time-scales compatible to those required for industrial innovations to reach the market.