Investigation of endocrine-disrupting chemicals as contributors to progression of metabolic dysfunction-associated steatotic liver disease

Deliverables

D7.4 Cluster common Data Management Plan

DMP

D3.1 Survey of available data from clinical cohorts

Report on data already available from European NAFLD Registry and collaborative cohorts

D4.2 Initial assessment of chemical exposures European NAFLD Registry

Assessment of chemical exposures in samples with existing omics data from the European NAFLD Registry

D7.6 Scientific strategy of the cluster

Scientific strategy of the cluster

D7.2 Cluster web portal and visual identity

Cluster web portal and visual identity

D7.1 Common cluster dissemination and communication strategy

Strategy document for the communication and dissemination messages and activities of the cluster

D8.2 Project website and corporate design

Website, EDC-MASLD brand, and templates established

D7.9 Thematic workshop/training on issue of common interest of the cluster projects

Thematic workshop/training on issue of common interest of the cluster projects

D7.5 Policy strategy of the cluster

Policy strategy of the cluster

D7.7 Cluster newsletter

Cluster newsletter

D7.3 Cluster brochure

Cluster brochure

D8.1 Dissemination and exploitation plan

Strategy document for the dissemination and exploitation, including communication activities.

Publications

Accelerating AOP Development in the AOP-Wiki with AI: A Practical Road Map for the Community

Author(s): You Song, Vikas Kumar, Shihori Tanabe, Daniel L. Villeneuve, Clemens Wittwehr
Published in: Environmental Science & Technology, 2026, ISSN 0013-936X
Publisher: American Chemical Society (ACS)
DOI: 10.1021/ACS.EST.6C05148

Metabolic and phenotypic changes induced by PFAS exposure in two human hepatocyte cell models

Author(s): Andi Alijagic, Lisanna Sinisalu, Daniel Duberg, Oleksandr Kotlyar, Nikolai Scherbak, Magnus Engwall, Matej Orešič, Tuulia Hyötyläinen
Published in: Environment International, Issue 190, 2024, ISSN 0160-4120
Publisher: Elsevier BV
DOI: 10.1016/J.ENVINT.2024.108820

Impact of Sexual Dimorphism on Therapy Response in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease: From Conventional and Nutritional Approaches to Emerging Therapies

Author(s): Eleonora Dileo, Francesca Saba, Mirko Parasiliti-Caprino, Chiara Rosso, Elisabetta Bugianesi
Published in: Nutrients, Issue 17, 2025, ISSN 2072-6643
Publisher: MDPI AG
DOI: 10.3390/NU17030477

Metabolic and phenotypic changes induced by PFAS exposure in two human hepatocyte cell models

Author(s): Andi Alijagic, Lisanna Sinisalu, Daniel Duberg, Oleksandr Kotlyar, Nikolai Scherbak, Magnus Engwall, Matej Orešič, Tuulia Hyötyläinen
Published in: Environment International, Issue 190, 2024, ISSN 0160-4120
Publisher: Elsevier BV
DOI: 10.1016/J.ENVINT.2024.108820

Next Generation Risk Assessment of Emerging PFOA Alternatives Using Integrated New Approach Methodologies

Author(s): You Song, Xueqi Fan, Maria T. Hultman, Maria Christou, Jan Thomas Rundberget, Camden K. Klefbom, Yan Lin, Yangzhao Sun, Jun Huang, Li Xie
Published in: Environmental Science & Technology, 2025, ISSN 0013-936X
Publisher: American Chemical Society (ACS)
DOI: 10.1021/ACS.EST.5C11122

Metabolic effects and biotransformation of perfluorohexyloctane in human hepatocytes

Author(s): Andi Alijagic, Jade Chaker, João Marcos G. Barbosa, Daniel Duberg, Victor Castro-Alves, Alex M. Dickens, Matej Orešič, Tuulia Hyötyläinen
Published in: Environment International, Issue 208, 2026, ISSN 0160-4120
Publisher: Elsevier BV
DOI: 10.1016/J.ENVINT.2026.110112

The SIMPLIFY Protocol: A Monophasic Extraction System Suitable for Exposomics, Metabolomics, Lipidomics, and Proteomics Research

Author(s): Nguyen, Anh Hoang and Castro-Alves, Victor and Holmström Flores, Emilia and Barbosa, João Marcos G. and Kråkström, Matilda and Reinivuori, Päivikki and Kauko, Otto and Dickens, Alex and Orešič, Matej and Hyötyläinen, Tuulia
Published in: Analytical Chemistry, ISSN 1520-6882
Publisher: ACS Publications
DOI: 10.1021/ACS.ANALCHEM.5C05322

PFAS exposure modulates mitochondrial susceptibility in steatotic hepatocytes

Author(s): João Marcos G. Barbosa, Andi Alijagic, Anh Hoang Nguyen, Victor Castro-Alves, Lorane Valgueblasse, Matej Orešič, Tuulia Hyötyläinen
Published in: Environment International, 2026, ISSN 0160-4120
Publisher: Elsevier BV
DOI: 10.1016/J.ENVINT.2026.110337

Next Generation Risk Assessment of Emerging PFOA Alternatives Using Integrated New Approach Methodologies

Author(s): You Song, Xueqi Fan, Maria T. Hultman, Maria Christou, Jan Thomas Rundberget, Camden K. Klefbom, Yan Lin, Yangzhao Sun, Jun Huang, Li Xie
Published in: Environmental Science & Technology, Issue 59, 2025, ISSN 0013-936X
Publisher: American Chemical Society (ACS)
DOI: 10.1021/ACS.EST.5C11122

Impact of Sexual Dimorphism on Therapy Response in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease: From Conventional and Nutritional Approaches to Emerging Therapies

Author(s): Eleonora Dileo, Francesca Saba, Mirko Parasiliti-Caprino, Chiara Rosso, Elisabetta Bugianesi
Published in: Nutrients, Issue 17, 2025, ISSN 2072-6643
Publisher: MDPI AG
DOI: 10.3390/nu17030477

Perfluorohexyloctane: More than Meets the Eye?

Author(s): Andi Alijagic, Matej Orešič, Tuulia Hyötyläinen
Published in: Chemical Research in Toxicology, Issue 39, 2026, ISSN 0893-228X
Publisher: American Chemical Society (ACS)
DOI: 10.1021/ACS.CHEMRESTOX.5C00507

Cytochrome P4501A1-Catalyzed Regioselective Activation Mechanism of PAHs and Their Nitrogen-Containing Derivatives

Author(s): Zexi Hou, Chenyang Tong, Mingna Zheng, Weixin Zhang, Qingzhu Zhang, Wenxing Wang, Yanwei Li
Published in: Chemical Research in Toxicology, Issue 39, 2026, ISSN 0893-228X
Publisher: American Chemical Society (ACS)
DOI: 10.1021/ACS.CHEMRESTOX.5C00508

Deliverables

Publications

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