Investigation of endocrine-disrupting chemicals as contributors to progression of metabolic dysfunction-associated steatotic liver disease

Informazioni relative al progetto

EDC-MASLD

ID dell’accordo di sovvenzione: 101136259

DOI

10.3030/101136259

Data della firma CE 10 Novembre 2023

Data di avvio 1 Gennaio 2024

Data di completamento 31 Dicembre 2028

Finanziato da

• Health

Costo totale

€ 7 053 942,75

Contributo UE

€ 7 053 942,75

Coordinato da

OREBRO UNIVERSITY
Sweden

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Documents, reports (12)

D7.4 Cluster common Data Management Plan

DMP

D3.1 Survey of available data from clinical cohorts

Report on data already available from European NAFLD Registry and collaborative cohorts

D4.2 Initial assessment of chemical exposures European NAFLD Registry

Assessment of chemical exposures in samples with existing omics data from the European NAFLD Registry

D7.6 Scientific strategy of the cluster

Scientific strategy of the cluster

D7.2 Cluster web portal and visual identity

Cluster web portal and visual identity

D7.1 Common cluster dissemination and communication strategy

Strategy document for the communication and dissemination messages and activities of the cluster

D8.2 Project website and corporate design

Website, EDC-MASLD brand, and templates established

D7.9 Thematic workshop/training on issue of common interest of the cluster projects

Thematic workshop/training on issue of common interest of the cluster projects

D7.5 Policy strategy of the cluster

Policy strategy of the cluster

D7.7 Cluster newsletter

Cluster newsletter

D7.3 Cluster brochure

Cluster brochure

D8.1 Dissemination and exploitation plan

Strategy document for the dissemination and exploitation, including communication activities.

Pubblicazioni

Peer reviewed articles (12)

Accelerating AOP Development in the AOP-Wiki with AI: A Practical Road Map for the Community

Autori: You Song, Vikas Kumar, Shihori Tanabe, Daniel L. Villeneuve, Clemens Wittwehr
Pubblicato in: Environmental Science & Technology, 2026, ISSN 0013-936X
Editore: American Chemical Society (ACS)
DOI: 10.1021/ACS.EST.6C05148

Metabolic and phenotypic changes induced by PFAS exposure in two human hepatocyte cell models

Autori: Andi Alijagic, Lisanna Sinisalu, Daniel Duberg, Oleksandr Kotlyar, Nikolai Scherbak, Magnus Engwall, Matej Orešič, Tuulia Hyötyläinen
Pubblicato in: Environment International, Numero 190, 2024, ISSN 0160-4120
Editore: Elsevier BV
DOI: 10.1016/J.ENVINT.2024.108820

Impact of Sexual Dimorphism on Therapy Response in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease: From Conventional and Nutritional Approaches to Emerging Therapies

Autori: Eleonora Dileo, Francesca Saba, Mirko Parasiliti-Caprino, Chiara Rosso, Elisabetta Bugianesi
Pubblicato in: Nutrients, Numero 17, 2025, ISSN 2072-6643
Editore: MDPI AG
DOI: 10.3390/NU17030477

Metabolic and phenotypic changes induced by PFAS exposure in two human hepatocyte cell models

Autori: Andi Alijagic, Lisanna Sinisalu, Daniel Duberg, Oleksandr Kotlyar, Nikolai Scherbak, Magnus Engwall, Matej Orešič, Tuulia Hyötyläinen
Pubblicato in: Environment International, Numero 190, 2024, ISSN 0160-4120
Editore: Elsevier BV
DOI: 10.1016/J.ENVINT.2024.108820

Next Generation Risk Assessment of Emerging PFOA Alternatives Using Integrated New Approach Methodologies

Autori: You Song, Xueqi Fan, Maria T. Hultman, Maria Christou, Jan Thomas Rundberget, Camden K. Klefbom, Yan Lin, Yangzhao Sun, Jun Huang, Li Xie
Pubblicato in: Environmental Science & Technology, 2025, ISSN 0013-936X
Editore: American Chemical Society (ACS)
DOI: 10.1021/ACS.EST.5C11122

Metabolic effects and biotransformation of perfluorohexyloctane in human hepatocytes

Autori: Andi Alijagic, Jade Chaker, João Marcos G. Barbosa, Daniel Duberg, Victor Castro-Alves, Alex M. Dickens, Matej Orešič, Tuulia Hyötyläinen
Pubblicato in: Environment International, Numero 208, 2026, ISSN 0160-4120
Editore: Elsevier BV
DOI: 10.1016/J.ENVINT.2026.110112

The SIMPLIFY Protocol: A Monophasic Extraction System Suitable for Exposomics, Metabolomics, Lipidomics, and Proteomics Research

Autori: Nguyen, Anh Hoang and Castro-Alves, Victor and Holmström Flores, Emilia and Barbosa, João Marcos G. and Kråkström, Matilda and Reinivuori, Päivikki and Kauko, Otto and Dickens, Alex and Orešič, Matej and Hyötyläinen, Tuulia
Pubblicato in: Analytical Chemistry, ISSN 1520-6882
Editore: ACS Publications
DOI: 10.1021/ACS.ANALCHEM.5C05322

PFAS exposure modulates mitochondrial susceptibility in steatotic hepatocytes

Autori: João Marcos G. Barbosa, Andi Alijagic, Anh Hoang Nguyen, Victor Castro-Alves, Lorane Valgueblasse, Matej Orešič, Tuulia Hyötyläinen
Pubblicato in: Environment International, 2026, ISSN 0160-4120
Editore: Elsevier BV
DOI: 10.1016/J.ENVINT.2026.110337

Next Generation Risk Assessment of Emerging PFOA Alternatives Using Integrated New Approach Methodologies

Autori: You Song, Xueqi Fan, Maria T. Hultman, Maria Christou, Jan Thomas Rundberget, Camden K. Klefbom, Yan Lin, Yangzhao Sun, Jun Huang, Li Xie
Pubblicato in: Environmental Science & Technology, Numero 59, 2025, ISSN 0013-936X
Editore: American Chemical Society (ACS)
DOI: 10.1021/ACS.EST.5C11122

Impact of Sexual Dimorphism on Therapy Response in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease: From Conventional and Nutritional Approaches to Emerging Therapies

Autori: Eleonora Dileo, Francesca Saba, Mirko Parasiliti-Caprino, Chiara Rosso, Elisabetta Bugianesi
Pubblicato in: Nutrients, Numero 17, 2025, ISSN 2072-6643
Editore: MDPI AG
DOI: 10.3390/nu17030477

Perfluorohexyloctane: More than Meets the Eye?

Autori: Andi Alijagic, Matej Orešič, Tuulia Hyötyläinen
Pubblicato in: Chemical Research in Toxicology, Numero 39, 2026, ISSN 0893-228X
Editore: American Chemical Society (ACS)
DOI: 10.1021/ACS.CHEMRESTOX.5C00507

Cytochrome P4501A1-Catalyzed Regioselective Activation Mechanism of PAHs and Their Nitrogen-Containing Derivatives

Autori: Zexi Hou, Chenyang Tong, Mingna Zheng, Weixin Zhang, Qingzhu Zhang, Wenxing Wang, Yanwei Li
Pubblicato in: Chemical Research in Toxicology, Numero 39, 2026, ISSN 0893-228X
Editore: American Chemical Society (ACS)
DOI: 10.1021/ACS.CHEMRESTOX.5C00508