Investigation of endocrine-disrupting chemicals as contributors to progression of metabolic dysfunction-associated steatotic liver disease

Livrables

D7.4 Cluster common Data Management Plan

DMP

D3.1 Survey of available data from clinical cohorts

Report on data already available from European NAFLD Registry and collaborative cohorts

D4.2 Initial assessment of chemical exposures European NAFLD Registry

Assessment of chemical exposures in samples with existing omics data from the European NAFLD Registry

D7.6 Scientific strategy of the cluster

Scientific strategy of the cluster

D7.2 Cluster web portal and visual identity

Cluster web portal and visual identity

D7.1 Common cluster dissemination and communication strategy

Strategy document for the communication and dissemination messages and activities of the cluster

D8.2 Project website and corporate design

Website, EDC-MASLD brand, and templates established

D7.9 Thematic workshop/training on issue of common interest of the cluster projects

Thematic workshop/training on issue of common interest of the cluster projects

D7.5 Policy strategy of the cluster

Policy strategy of the cluster

D7.7 Cluster newsletter

Cluster newsletter

D7.3 Cluster brochure

Cluster brochure

D8.1 Dissemination and exploitation plan

Strategy document for the dissemination and exploitation, including communication activities.

Publications

Accelerating AOP Development in the AOP-Wiki with AI: A Practical Road Map for the Community

Auteurs: You Song, Vikas Kumar, Shihori Tanabe, Daniel L. Villeneuve, Clemens Wittwehr
Publié dans: Environmental Science & Technology, 2026, ISSN 0013-936X
Éditeur: American Chemical Society (ACS)
DOI: 10.1021/ACS.EST.6C05148

Metabolic and phenotypic changes induced by PFAS exposure in two human hepatocyte cell models

Auteurs: Andi Alijagic, Lisanna Sinisalu, Daniel Duberg, Oleksandr Kotlyar, Nikolai Scherbak, Magnus Engwall, Matej Orešič, Tuulia Hyötyläinen
Publié dans: Environment International, Numéro 190, 2024, ISSN 0160-4120
Éditeur: Elsevier BV
DOI: 10.1016/J.ENVINT.2024.108820

Impact of Sexual Dimorphism on Therapy Response in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease: From Conventional and Nutritional Approaches to Emerging Therapies

Auteurs: Eleonora Dileo, Francesca Saba, Mirko Parasiliti-Caprino, Chiara Rosso, Elisabetta Bugianesi
Publié dans: Nutrients, Numéro 17, 2025, ISSN 2072-6643
Éditeur: MDPI AG
DOI: 10.3390/NU17030477

Metabolic and phenotypic changes induced by PFAS exposure in two human hepatocyte cell models

Auteurs: Andi Alijagic, Lisanna Sinisalu, Daniel Duberg, Oleksandr Kotlyar, Nikolai Scherbak, Magnus Engwall, Matej Orešič, Tuulia Hyötyläinen
Publié dans: Environment International, Numéro 190, 2024, ISSN 0160-4120
Éditeur: Elsevier BV
DOI: 10.1016/J.ENVINT.2024.108820

Next Generation Risk Assessment of Emerging PFOA Alternatives Using Integrated New Approach Methodologies

Auteurs: You Song, Xueqi Fan, Maria T. Hultman, Maria Christou, Jan Thomas Rundberget, Camden K. Klefbom, Yan Lin, Yangzhao Sun, Jun Huang, Li Xie
Publié dans: Environmental Science & Technology, 2025, ISSN 0013-936X
Éditeur: American Chemical Society (ACS)
DOI: 10.1021/ACS.EST.5C11122

Metabolic effects and biotransformation of perfluorohexyloctane in human hepatocytes

Auteurs: Andi Alijagic, Jade Chaker, João Marcos G. Barbosa, Daniel Duberg, Victor Castro-Alves, Alex M. Dickens, Matej Orešič, Tuulia Hyötyläinen
Publié dans: Environment International, Numéro 208, 2026, ISSN 0160-4120
Éditeur: Elsevier BV
DOI: 10.1016/J.ENVINT.2026.110112

The SIMPLIFY Protocol: A Monophasic Extraction System Suitable for Exposomics, Metabolomics, Lipidomics, and Proteomics Research

Auteurs: Anh Hoang Nguyen, Victor Castro-Alves, Emilia Holmström Flores, João Marcos G. Barbosa, Matilda Kråkström, Päivikki Reinivuori, Otto Kauko, Alex Dickens, Matej Orešič, Tuulia Hyötyläinen
Publié dans: Analytical Chemistry, Numéro 97, 2025, ISSN 0003-2700
Éditeur: American Chemical Society (ACS)
DOI: 10.1021/ACS.ANALCHEM.5C05322

PFAS exposure modulates mitochondrial susceptibility in steatotic hepatocytes

Auteurs: João Marcos G. Barbosa, Andi Alijagic, Anh Hoang Nguyen, Victor Castro-Alves, Lorane Valgueblasse, Matej Orešič, Tuulia Hyötyläinen
Publié dans: Environment International, 2026, ISSN 0160-4120
Éditeur: Elsevier BV
DOI: 10.1016/J.ENVINT.2026.110337

Next Generation Risk Assessment of Emerging PFOA Alternatives Using Integrated New Approach Methodologies

Auteurs: You Song, Xueqi Fan, Maria T. Hultman, Maria Christou, Jan Thomas Rundberget, Camden K. Klefbom, Yan Lin, Yangzhao Sun, Jun Huang, Li Xie
Publié dans: Environmental Science & Technology, Numéro 59, 2025, ISSN 0013-936X
Éditeur: American Chemical Society (ACS)
DOI: 10.1021/ACS.EST.5C11122

Impact of Sexual Dimorphism on Therapy Response in Patients with Metabolic Dysfunction-Associated Steatotic Liver Disease: From Conventional and Nutritional Approaches to Emerging Therapies

Auteurs: Eleonora Dileo, Francesca Saba, Mirko Parasiliti-Caprino, Chiara Rosso, Elisabetta Bugianesi
Publié dans: Nutrients, Numéro 17, 2025, ISSN 2072-6643
Éditeur: MDPI AG
DOI: 10.3390/nu17030477

The Hepato-Exposome Axis: How Endocrine Disruptors Hijack Liver Receptors to Drive MASLD

Auteurs: M. Martín-Grau, J.H. Kamstra, T. Hyötyläinen, M. Orešič, Y. Song, N. Veličković, A. Djordjevic, D. Vojnović Milutinović, R.F. Jackson, R. van Vorstenbosch, J. Massart, A. Vidal-Puig, S. Carobbio
Publié dans: Journal of Hepatology, 2026, ISSN 0168-8278
Éditeur: Elsevier BV
DOI: 10.1016/J.JHEP.2026.06.021

Perfluorohexyloctane: More than Meets the Eye?

Auteurs: Andi Alijagic, Matej Orešič, Tuulia Hyötyläinen
Publié dans: Chemical Research in Toxicology, Numéro 39, 2026, ISSN 0893-228X
Éditeur: American Chemical Society (ACS)
DOI: 10.1021/ACS.CHEMRESTOX.5C00507

Prospective validation of imaging and serum diagnostic biomarkers of steatohepatitis and fibrosis in MASLD: the LITMUS Imaging Study

Auteurs: Michael Pavlides, Yasaman Vali, Ferenc E. Mózes, Kristy Wonders, Salma Akhtar, Paul D. Hockings, Elizabeth Shumbayawonda, Kay Pepin, Isabel Fernandez-Lizaranzu, Diana Julie Leeming, Jeremy F. Cobbold, Michael E. D. Allison, Guruprasad P. Aithal, Manuel Romero-Gomez, Rocio Aller, Juan M. Pericàs, Jérôme Boursier, Salvatore Petta, Jörn M. Schattenberg, Mattias Ekstedt, Annalisa Berzigotti, Hannele Yki-Järvinen, Miljen Martic, Theresa Tuthill, Clifford A. Brass, Michael Kalutkiewicz, Rajarshi Banerjee, Richard L. Ehman, Moritz J. Schneider, Dina Tiniakos, Morten Karsdal, Jeremy Magnanensi, Céline Fournier-Poizat, Vlad Ratziu, Carla Yunis, Elisabetta Bugianesi, Stephen A. Harrison, null null, Quentin M. Anstee, Ann Daly, Fiona Oakley, Simon J. Cockell, Dina Tiniakos, Pierre Bedossa, Heather J. Cordell, Christopher P. Day, Kristy Wonders, Olivier Govaere, Paolo Missier, Matthew McTeer, Luke Vale, Yemi Oliboyede, Matt Breckons, Patrick M. Bossuyt, Yasaman Vali, Jenny Lee, Max Nieuwdorp, Yair Acherman, Arnold van de Laar, Athanasios Angelakis, Adriaan G. Holleboom, Vlad Ratziu, Karine Clément, Rafael Patino-Navarrete, Raluca Pais, Valerie Paradis, Mathilde Wagner, Jörn M. Schattenberg, Maurice Michel, Detlef Schuppan, Sudha Myneni, Rambabu Surabattula, Beate K. Straub, Emrich Tilman, Toni Vidal-Puig, Sergio Rodrigues-Cuenca, Ioannis Kamzolas, Evangelia Petsalaki, Mark Campbell, Chris J. Lelliott, Michael E. D. Allison, Susan Davies, Edmund Godfrey, Michele Vacca, Matej Orešič, Aidan McGlinchey, Tuulia Hyötyläinen, Jose M. Mato, Óscar Millet, Annalisa Berzigotti, Jean-François Dufour, Naomi F. Lange, Adrian T. Huber, Michael Pavlides, Jeremy F. Cobbold, Stefan Neubauer, Ferenc E. Mozes, Salma Akhtar, Stephen A. Harrison, Seliat Olodo-Atitebi, Rajarshi Banerjee, Elizabeth Shumbayawonda, Andrea Dennis, Anneli Andersson, Manuel Romero-Gómez, Rocío Gallego-Durán, Rocío Montero-Vallejo, Isabel Fernandez-Lizarazu, Sheila Gato, Javier Castell, Morten Karsdal, Diana Julie Leeming, Kishwar Musa, Maria Manuela Tonini, Elisabetta Bugianesi, Chiara Rosso, Angelo Armandi, Ricardo Faletti, Fabio Marra, Amalia Gastaldelli, Fabrizia Carli, Gianluca Svegliati-Baroni, Jérôme Boursier, Marc de Saint Loup, Pierre Celea, Christophe Aube, Sven M. A. Francque, Wilhelmus J. Kwanten, Luisa Vonghia, An Verrijken, Eveline Dirinck, Ann Driessen, Mattias Ekstedt, Stergios Kechagias, Peter Lundberg, Hannele Yki-Järvinen, Kimmo Porthan, Johanna Arola, Saskia van Mil, George Papatheodoridis, Helena Cortez-Pinto, Mariana Verdelho Machado, Sofia Carvalhana, Cecilia M. P. Rodrigues, Luca V. C. Valenti, Serena Pelusi, Salvatore Petta, Grazia Penisi, Rosaria Maria Pipitone, Adele Tulone, Stefania Grimaudo, Michela Antonucci, Luca Miele, Antonio Liguori, Francesca D’Ambrosio, Andreas Geier, P. D. Monika Rau, Hans Benno Leicht, Florian Reiter, Guruprasad P. Aithal, Susan Francis, Naaventhan Palaniyappan, Christopher Bradley, Paul D. Hockings, Moritz J. Schneider, Philip N. Newsome, David Wenn, Jeremy Magnanensi, Aldo Trylesinski, Rebeca Mayo, Cristina Alonso, Kevin L. Duffin, James W. Perfield, Mark L. Hartman, Yu Chen, Carla Yunis, Theresa Tuthill, Trenton Ross, Barbara Bernardo, Magdalena Alicja Harrington, Euan McLeod, Judith Ertle, Ramy Younes, Harvey Coxson, Joseph Gogain, Hannah R. Biegel, Leigh Alexander, Rachel Ostroff, Mette Skalshøi Kjær, Lea Mørch Harder, Sanne S. Veidal, Naba Al-Sari, Daniel Guldager Kring Rasmussen, Maria-Magdalena Balp, Clifford A. Brass, Lori Jennings, Miljen Martic, Jurgen Loffler, Douglas Applegate, Richard Torstenson, Daniel Lindén, Céline Fournier-Poizat, Anne Llorca, Michael Kalutkiewicz, Richard L. Ehman, Kay Pepin, Gerald Horan, Gideon Ho, Dean Tai, Elaine Chng, Yayun Ren, Scott D. Patterson, Andrew N. Billin, Lynda C. Doward, James Twiss, Paresh Thakker, Zoltan Derdak, Henrik Landgren, Carolin Lackner, Annette S. H. Gouw, Prodromos Hytiroglou, Rocio Aller, Rebeca Sigüenza González, Juan M. Pericàs, Sal
Publié dans: Nature Medicine, 2026, ISSN 1078-8956
Éditeur: Springer Science and Business Media LLC
DOI: 10.1038/S41591-026-04496-2

Cytochrome P4501A1-Catalyzed Regioselective Activation Mechanism of PAHs and Their Nitrogen-Containing Derivatives

Auteurs: Zexi Hou, Chenyang Tong, Mingna Zheng, Weixin Zhang, Qingzhu Zhang, Wenxing Wang, Yanwei Li
Publié dans: Chemical Research in Toxicology, Numéro 39, 2026, ISSN 0893-228X
Éditeur: American Chemical Society (ACS)
DOI: 10.1021/ACS.CHEMRESTOX.5C00508

Resultats de projets

Livrables

Publications

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