Towards GEMINI: A Generation of Multi-scale Digital Twins of Ischaemic and Haemorrhagic Stroke Patients

Deliverables

Testing at scale – procedure description
Project Handbook
standards, inputs/outputs, model repository, QoI, CoU, and infrastructure to set up the generic digital twin

standards, inputs/outputs, model repository, QoI, CoU, andinfrastructure to set up the generic digital twin

VVUQ roadmap for GEMINI models
StC meeting minutes
Aetiology of clot formation and clot characteristics
Software engineering guidelines

Creation of project website

Publications

Disentangling determinants of one-year modified Rankin scale in patients with incidentally detected solitary intracranial aneurysms

Author(s): Lea Bührer, Lisa L. Richard, Alexandre Genoud, Abiram Sandralegar, Julien Haemmerli, Insa K. Janssen, Jeremy Hofmeister, Andrea Rosi, Gianmarco Bernava, Paolo Machi, Karl Schaller, Sandrine Morel, Philippe Bijlenga, Vincent L’Allinec, Sven Hirsch, Reinhard Furrer, Georg R. Spinner
Published in: Computers in Biology and Medicine, Issue 210, 2026, ISSN 0010-4825
Publisher: Elsevier BV
DOI: 10.1016/J.COMPBIOMED.2026.111731

Sex differences in clot, vessel and tissue characteristics in patients with a large vessel occlusion treated with endovascular thrombectomy

Author(s): Anne van der Meij; Ghislaine Holswilder; Marie Louise E Bernsen; Hendrikus JA van Os; Jeannette Hofmeijer; Fianne HM Spaander; Jasper M Martens; Ido R van den Wijngaard; Hester F Lingsma; Praneeta R Konduri; Charles BLM Majoie; Wouter J Schonewille; Diederik WJ Dippel; Nyika D Kruyt; Paul J Nederkoorn; Marianne AA van Walderveen; Marieke JH Wermer
Published in: European Stroke Journal, 2024, ISSN 2396-9881
Publisher: SAGE Publications
DOI: 10.1177/23969873241231125

Computers in Biology and Medicine

Author(s): Yue Hao 0002; Claudia Tersteeg; Alfons G. Hoekstra; Gábor Závodszky
Published in: Computers in Biology and Medicine, 2024, ISSN 0010-4825
Publisher: Elsevier
DOI: 10.1016/J.COMPBIOMED.2024.109010

Mixed-effects additive Bayesian networks for the assessment of ruptured intracranial aneurysms: Insights from multicenter data

Author(s): Matteo Delucchi, Philippe Bijlenga, Sandrine Morel, Reinhard Furrer, Isabel C. Hostettler, Mark K. Bakker, Romain Bourcier, Antti Lindgren, Svenja Maschke, Oliver Bozinov, Henry Houlden, David Werring, Ynte M. Ruigrok, Maria Wostrack, Bernhard Meyer, Marian Christoph Neidert, Sven Hirsch, Georg R. Spinner
Published in: Computers in Biology and Medicine, Issue 201, 2026, ISSN 0010-4825
Publisher: Elsevier BV
DOI: 10.1016/J.COMPBIOMED.2025.111380

Impact of occluder device configurations in in-silico left atrial hemodynamics for the analysis of device-related thrombus

Author(s): Carlos Albors; Jordi Mill; Andy L. Olivares; Xavier Iriart; Hubert Cochet; Oscar Camara
Published in: PLOS Computational Biology, 2024, ISSN 1553-7358
Publisher: Public Library of Science
DOI: 10.1371/JOURNAL.PCBI.1011546

Unsupervised Clustering of Patients Undergoing Thoracoscopic Ablation Identifies Relevant Phenotypes for Advanced Atrial Fibrillation

Author(s): Ilse Meijer; Marc M. Terpstra; Oscar Camara; Henk A. Marquering; Nerea Arrarte Terreros; Joris R. de Groot
Published in: Diagnostics, 2025, ISSN 2075-4418
Publisher: MDPI
DOI: 10.3390/DIAGNOSTICS15101269

Clinical image analysis to build patient-specific models of acute ischemic stroke patients

Author(s): Virginia Fregona; Ilaria Bottini; Sara Barati; Amedeo Cervo; Antonio Macera; Ghil Schwarz; Guglielmo Pero; Mariangela Piano; Gabriele Dubini; Jose Felix Rodriguez Matas; Giulia Luraghi; Francesco Migliavacca
Published in: Physical and Engineering Sciences in Medicine, 2025, ISSN 2662-4729
Publisher: Springer Nature
DOI: 10.1007/S13246-025-01646-7

The Role of Anticoagulants After Left Atrial Appendage Occlusion

Author(s): Maria Segarra-Queralt, Marc Molla, Manal Barrouhou, Andy L. Olivares, Carlos Albors, Gabriel Bernardino, Ander Regueiro, Jordi Mill, Òscar Càmara, Xavier Freixa
Published in: JACC: Case Reports, Issue 30, 2026, ISSN 2666-0849
Publisher: Elsevier BV
DOI: 10.1016/J.JACCAS.2025.105838

Impact of thrombus composition on virtual thrombectomy procedures using human clot analogues mechanical data

Author(s): Virginia Fregona, Giulia Luraghi, Behrooz Fereidoonnezhad, Frank J.H. Gijsen, Charles B.L.M. Majoie, Jose Felix Rodríguez Matas, Francesco Migliavacca
Published in: Journal of the Mechanical Behavior of Biomedical Materials, Issue 163, 2025, ISSN 1751-6161
Publisher: Elsevier BV
DOI: 10.1016/J.JMBBM.2025.106886

Frontiers in Neurology

Author(s): Olszewski, Wiktor; Cavalcante, Fabiano; van Poppel, Laura; Beenen, Ludo; Emmer, Bart J.; van den Wijngaard, Ido; Lemmens, Robin; Roos, Yvo; Marquering, Henk; Konduri, Praneeta; Majoie, Charles
Published in: Frontiers in Neurology, 2025, ISSN 1664-2295
Publisher: Frontiers SA
DOI: 10.3389/FNEUR.2025.1698480

Digital twin integrating clinical, morphological and hemodynamic data to identify stroke risk factors

Author(s): Saiz-Vivó, Marta; Mill, Jordi; Iriart, Xavier; Cochet, Hubert; Piella, Gemma; Sermesant, Maxime; Camara, Oscar
Published in: npj Digital Medicine, 2025, ISSN 2398-6352
Publisher: Nature portfolio
DOI: 10.21203/RS.3.RS-5206065/V1

Endovascular treatment of unruptured intracranial aneurysms at a single center: Outcomes, selection strategy, and transparent communication for patient decision-making

Author(s): Gianmarco Bernava, Abiram Sandralegar, Jeremy Hofmeister, Andrea Rosi, Hasan Yilmaz, Sandrine Morel, Philippe Reymond, Olivier Brina, Michel Muster, Karl-Olof Lovblad, Karl Schaller, Philippe Bijlenga, Paolo Machi
Published in: Interventional Neuroradiology, 2026, ISSN 1591-0199
Publisher: SAGE Publications
DOI: 10.1177/15910199251394476

Impact of friction force and retrieval speed on in silico mechanical thrombectomies: A sensitivity analysis

Author(s): Mahesh S. Nagargoje, Virginia Fregona, Giulia Luraghi, Francesco Migliavacca, Demitria A Poulos, Bryan C Good, Jose Felix Rodriguez Matas
Published in: Computer Methods and Programs in Biomedicine, Issue 271, 2026, ISSN 0169-2607
Publisher: Elsevier BV
DOI: 10.1016/J.CMPB.2025.109018

Deliverables

Publications

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