Towards GEMINI: A Generation of Multi-scale Digital Twins of Ischaemic and Haemorrhagic Stroke Patients

Información del proyecto

GEMINI

Identificador del acuerdo de subvención: 101136438

DOI

10.3030/101136438

Fecha de la firma de la CE 23 Noviembre 2023

Fecha de inicio 1 Diciembre 2023

Fecha de finalización 30 Noviembre 2029

Financiado con arreglo a

• Health

Coste total

€ 9 991 877,50

Aportación de la UE

€ 9 991 877,50

Coordinado por

STICHTING AMSTERDAM UMC
Netherlands

CORDIS proporciona enlaces a los documentos públicos y las publicaciones de los proyectos de los programas marco HORIZONTE.

Los enlaces a los documentos y las publicaciones de los proyectos del Séptimo Programa Marco, así como los enlaces a algunos tipos de resultados específicos, como conjuntos de datos y «software», se obtienen dinámicamente de OpenAIRE .

Resultado final

Data Management Plan (1)

Updated Data management Plan

Documents, reports (7)

Testing at scale – procedure description
Project Handbook
standards, inputs/outputs, model repository, QoI, CoU, and infrastructure to set up the generic digital twin

standards, inputs/outputs, model repository, QoI, CoU, andinfrastructure to set up the generic digital twin

VVUQ roadmap for GEMINI models
StC meeting minutes
Aetiology of clot formation and clot characteristics
Software engineering guidelines

Demonstrators, pilots, prototypes (1)

Creation of project website

Publicaciones

Peer reviewed articles (13)

Disentangling determinants of one-year modified Rankin scale in patients with incidentally detected solitary intracranial aneurysms

Autores: Lea Bührer, Lisa L. Richard, Alexandre Genoud, Abiram Sandralegar, Julien Haemmerli, Insa K. Janssen, Jeremy Hofmeister, Andrea Rosi, Gianmarco Bernava, Paolo Machi, Karl Schaller, Sandrine Morel, Philippe Bijlenga, Vincent L’Allinec, Sven Hirsch, Reinhard Furrer, Georg R. Spinner
Publicado en: Computers in Biology and Medicine, Edición 210, 2026, ISSN 0010-4825
Editor: Elsevier BV
DOI: 10.1016/J.COMPBIOMED.2026.111731

Sex differences in clot, vessel and tissue characteristics in patients with a large vessel occlusion treated with endovascular thrombectomy

Autores: Anne van der Meij; Ghislaine Holswilder; Marie Louise E Bernsen; Hendrikus JA van Os; Jeannette Hofmeijer; Fianne HM Spaander; Jasper M Martens; Ido R van den Wijngaard; Hester F Lingsma; Praneeta R Konduri; Charles BLM Majoie; Wouter J Schonewille; Diederik WJ Dippel; Nyika D Kruyt; Paul J Nederkoorn; Marianne AA van Walderveen; Marieke JH Wermer
Publicado en: European Stroke Journal, 2024, ISSN 2396-9881
Editor: SAGE Publications
DOI: 10.1177/23969873241231125

Computers in Biology and Medicine

Autores: Yue Hao 0002; Claudia Tersteeg; Alfons G. Hoekstra; Gábor Závodszky
Publicado en: Computers in Biology and Medicine, 2024, ISSN 0010-4825
Editor: Elsevier
DOI: 10.1016/J.COMPBIOMED.2024.109010

Mixed-effects additive Bayesian networks for the assessment of ruptured intracranial aneurysms: Insights from multicenter data

Autores: Matteo Delucchi, Philippe Bijlenga, Sandrine Morel, Reinhard Furrer, Isabel C. Hostettler, Mark K. Bakker, Romain Bourcier, Antti Lindgren, Svenja Maschke, Oliver Bozinov, Henry Houlden, David Werring, Ynte M. Ruigrok, Maria Wostrack, Bernhard Meyer, Marian Christoph Neidert, Sven Hirsch, Georg R. Spinner
Publicado en: Computers in Biology and Medicine, Edición 201, 2026, ISSN 0010-4825
Editor: Elsevier BV
DOI: 10.1016/J.COMPBIOMED.2025.111380

Impact of occluder device configurations in in-silico left atrial hemodynamics for the analysis of device-related thrombus

Autores: Carlos Albors; Jordi Mill; Andy L. Olivares; Xavier Iriart; Hubert Cochet; Oscar Camara
Publicado en: PLOS Computational Biology, 2024, ISSN 1553-7358
Editor: Public Library of Science
DOI: 10.1371/JOURNAL.PCBI.1011546

Unsupervised Clustering of Patients Undergoing Thoracoscopic Ablation Identifies Relevant Phenotypes for Advanced Atrial Fibrillation

Autores: Ilse Meijer; Marc M. Terpstra; Oscar Camara; Henk A. Marquering; Nerea Arrarte Terreros; Joris R. de Groot
Publicado en: Diagnostics, 2025, ISSN 2075-4418
Editor: MDPI
DOI: 10.3390/DIAGNOSTICS15101269

Clinical image analysis to build patient-specific models of acute ischemic stroke patients

Autores: Virginia Fregona; Ilaria Bottini; Sara Barati; Amedeo Cervo; Antonio Macera; Ghil Schwarz; Guglielmo Pero; Mariangela Piano; Gabriele Dubini; Jose Felix Rodriguez Matas; Giulia Luraghi; Francesco Migliavacca
Publicado en: Physical and Engineering Sciences in Medicine, 2025, ISSN 2662-4729
Editor: Springer Nature
DOI: 10.1007/S13246-025-01646-7

The Role of Anticoagulants After Left Atrial Appendage Occlusion

Autores: Maria Segarra-Queralt, Marc Molla, Manal Barrouhou, Andy L. Olivares, Carlos Albors, Gabriel Bernardino, Ander Regueiro, Jordi Mill, Òscar Càmara, Xavier Freixa
Publicado en: JACC: Case Reports, Edición 30, 2026, ISSN 2666-0849
Editor: Elsevier BV
DOI: 10.1016/J.JACCAS.2025.105838

Impact of thrombus composition on virtual thrombectomy procedures using human clot analogues mechanical data

Autores: Virginia Fregona, Giulia Luraghi, Behrooz Fereidoonnezhad, Frank J.H. Gijsen, Charles B.L.M. Majoie, Jose Felix Rodríguez Matas, Francesco Migliavacca
Publicado en: Journal of the Mechanical Behavior of Biomedical Materials, Edición 163, 2025, ISSN 1751-6161
Editor: Elsevier BV
DOI: 10.1016/J.JMBBM.2025.106886

Frontiers in Neurology

Autores: Olszewski, Wiktor; Cavalcante, Fabiano; van Poppel, Laura; Beenen, Ludo; Emmer, Bart J.; van den Wijngaard, Ido; Lemmens, Robin; Roos, Yvo; Marquering, Henk; Konduri, Praneeta; Majoie, Charles
Publicado en: Frontiers in Neurology, 2025, ISSN 1664-2295
Editor: Frontiers SA
DOI: 10.3389/FNEUR.2025.1698480

Digital twin integrating clinical, morphological and hemodynamic data to identify stroke risk factors

Autores: Saiz-Vivó, Marta; Mill, Jordi; Iriart, Xavier; Cochet, Hubert; Piella, Gemma; Sermesant, Maxime; Camara, Oscar
Publicado en: npj Digital Medicine, 2025, ISSN 2398-6352
Editor: Nature portfolio
DOI: 10.21203/RS.3.RS-5206065/V1

Endovascular treatment of unruptured intracranial aneurysms at a single center: Outcomes, selection strategy, and transparent communication for patient decision-making

Autores: Gianmarco Bernava, Abiram Sandralegar, Jeremy Hofmeister, Andrea Rosi, Hasan Yilmaz, Sandrine Morel, Philippe Reymond, Olivier Brina, Michel Muster, Karl-Olof Lovblad, Karl Schaller, Philippe Bijlenga, Paolo Machi
Publicado en: Interventional Neuroradiology, 2026, ISSN 1591-0199
Editor: SAGE Publications
DOI: 10.1177/15910199251394476

Impact of friction force and retrieval speed on in silico mechanical thrombectomies: A sensitivity analysis

Autores: Mahesh S. Nagargoje, Virginia Fregona, Giulia Luraghi, Francesco Migliavacca, Demitria A Poulos, Bryan C Good, Jose Felix Rodriguez Matas
Publicado en: Computer Methods and Programs in Biomedicine, Edición 271, 2026, ISSN 0169-2607
Editor: Elsevier BV
DOI: 10.1016/J.CMPB.2025.109018