Towards GEMINI: A Generation of Multi-scale Digital Twins of Ischaemic and Haemorrhagic Stroke Patients

Informations projet

GEMINI

N° de convention de subvention: 101136438

DOI

10.3030/101136438

Date de signature de la CE 23 Novembre 2023

Date de début 1 Decembre 2023

Date de fin 30 Novembre 2029

Financé au titre de

• Health

Coût total

€ 9 991 877,50

Contribution de l’UE

€ 9 991 877,50

Coordonné par

STICHTING AMSTERDAM UMC
Netherlands

CORDIS fournit des liens vers les livrables publics et les publications des projets HORIZON.

Les liens vers les livrables et les publications des projets du 7e PC, ainsi que les liens vers certains types de résultats spécifiques tels que les jeux de données et les logiciels, sont récupérés dynamiquement sur OpenAIRE .

Livrables

Data Management Plan (1)

Updated Data management Plan

Documents, reports (7)

Testing at scale – procedure description
Project Handbook
standards, inputs/outputs, model repository, QoI, CoU, and infrastructure to set up the generic digital twin

standards, inputs/outputs, model repository, QoI, CoU, andinfrastructure to set up the generic digital twin

VVUQ roadmap for GEMINI models
StC meeting minutes
Aetiology of clot formation and clot characteristics
Software engineering guidelines

Demonstrators, pilots, prototypes (1)

Creation of project website

Publications

Peer reviewed articles (13)

Disentangling determinants of one-year modified Rankin scale in patients with incidentally detected solitary intracranial aneurysms

Auteurs: Lea Bührer, Lisa L. Richard, Alexandre Genoud, Abiram Sandralegar, Julien Haemmerli, Insa K. Janssen, Jeremy Hofmeister, Andrea Rosi, Gianmarco Bernava, Paolo Machi, Karl Schaller, Sandrine Morel, Philippe Bijlenga, Vincent L’Allinec, Sven Hirsch, Reinhard Furrer, Georg R. Spinner
Publié dans: Computers in Biology and Medicine, Numéro 210, 2026, ISSN 0010-4825
Éditeur: Elsevier BV
DOI: 10.1016/J.COMPBIOMED.2026.111731

Sex differences in clot, vessel and tissue characteristics in patients with a large vessel occlusion treated with endovascular thrombectomy

Auteurs: Anne van der Meij; Ghislaine Holswilder; Marie Louise E Bernsen; Hendrikus JA van Os; Jeannette Hofmeijer; Fianne HM Spaander; Jasper M Martens; Ido R van den Wijngaard; Hester F Lingsma; Praneeta R Konduri; Charles BLM Majoie; Wouter J Schonewille; Diederik WJ Dippel; Nyika D Kruyt; Paul J Nederkoorn; Marianne AA van Walderveen; Marieke JH Wermer
Publié dans: European Stroke Journal, 2024, ISSN 2396-9881
Éditeur: SAGE Publications
DOI: 10.1177/23969873241231125

Computers in Biology and Medicine

Auteurs: Yue Hao 0002; Claudia Tersteeg; Alfons G. Hoekstra; Gábor Závodszky
Publié dans: Computers in Biology and Medicine, 2024, ISSN 0010-4825
Éditeur: Elsevier
DOI: 10.1016/J.COMPBIOMED.2024.109010

Mixed-effects additive Bayesian networks for the assessment of ruptured intracranial aneurysms: Insights from multicenter data

Auteurs: Matteo Delucchi, Philippe Bijlenga, Sandrine Morel, Reinhard Furrer, Isabel C. Hostettler, Mark K. Bakker, Romain Bourcier, Antti Lindgren, Svenja Maschke, Oliver Bozinov, Henry Houlden, David Werring, Ynte M. Ruigrok, Maria Wostrack, Bernhard Meyer, Marian Christoph Neidert, Sven Hirsch, Georg R. Spinner
Publié dans: Computers in Biology and Medicine, Numéro 201, 2026, ISSN 0010-4825
Éditeur: Elsevier BV
DOI: 10.1016/J.COMPBIOMED.2025.111380

Impact of occluder device configurations in in-silico left atrial hemodynamics for the analysis of device-related thrombus

Auteurs: Carlos Albors; Jordi Mill; Andy L. Olivares; Xavier Iriart; Hubert Cochet; Oscar Camara
Publié dans: PLOS Computational Biology, 2024, ISSN 1553-7358
Éditeur: Public Library of Science
DOI: 10.1371/JOURNAL.PCBI.1011546

Unsupervised Clustering of Patients Undergoing Thoracoscopic Ablation Identifies Relevant Phenotypes for Advanced Atrial Fibrillation

Auteurs: Ilse Meijer; Marc M. Terpstra; Oscar Camara; Henk A. Marquering; Nerea Arrarte Terreros; Joris R. de Groot
Publié dans: Diagnostics, 2025, ISSN 2075-4418
Éditeur: MDPI
DOI: 10.3390/DIAGNOSTICS15101269

Clinical image analysis to build patient-specific models of acute ischemic stroke patients

Auteurs: Virginia Fregona; Ilaria Bottini; Sara Barati; Amedeo Cervo; Antonio Macera; Ghil Schwarz; Guglielmo Pero; Mariangela Piano; Gabriele Dubini; Jose Felix Rodriguez Matas; Giulia Luraghi; Francesco Migliavacca
Publié dans: Physical and Engineering Sciences in Medicine, 2025, ISSN 2662-4729
Éditeur: Springer Nature
DOI: 10.1007/S13246-025-01646-7

The Role of Anticoagulants After Left Atrial Appendage Occlusion

Auteurs: Maria Segarra-Queralt, Marc Molla, Manal Barrouhou, Andy L. Olivares, Carlos Albors, Gabriel Bernardino, Ander Regueiro, Jordi Mill, Òscar Càmara, Xavier Freixa
Publié dans: JACC: Case Reports, Numéro 30, 2026, ISSN 2666-0849
Éditeur: Elsevier BV
DOI: 10.1016/J.JACCAS.2025.105838

Impact of thrombus composition on virtual thrombectomy procedures using human clot analogues mechanical data

Auteurs: Virginia Fregona, Giulia Luraghi, Behrooz Fereidoonnezhad, Frank J.H. Gijsen, Charles B.L.M. Majoie, Jose Felix Rodríguez Matas, Francesco Migliavacca
Publié dans: Journal of the Mechanical Behavior of Biomedical Materials, Numéro 163, 2025, ISSN 1751-6161
Éditeur: Elsevier BV
DOI: 10.1016/J.JMBBM.2025.106886

Frontiers in Neurology

Auteurs: Olszewski, Wiktor; Cavalcante, Fabiano; van Poppel, Laura; Beenen, Ludo; Emmer, Bart J.; van den Wijngaard, Ido; Lemmens, Robin; Roos, Yvo; Marquering, Henk; Konduri, Praneeta; Majoie, Charles
Publié dans: Frontiers in Neurology, 2025, ISSN 1664-2295
Éditeur: Frontiers SA
DOI: 10.3389/FNEUR.2025.1698480

Digital twin integrating clinical, morphological and hemodynamic data to identify stroke risk factors

Auteurs: Saiz-Vivó, Marta; Mill, Jordi; Iriart, Xavier; Cochet, Hubert; Piella, Gemma; Sermesant, Maxime; Camara, Oscar
Publié dans: npj Digital Medicine, 2025, ISSN 2398-6352
Éditeur: Nature portfolio
DOI: 10.21203/RS.3.RS-5206065/V1

Endovascular treatment of unruptured intracranial aneurysms at a single center: Outcomes, selection strategy, and transparent communication for patient decision-making

Auteurs: Gianmarco Bernava, Abiram Sandralegar, Jeremy Hofmeister, Andrea Rosi, Hasan Yilmaz, Sandrine Morel, Philippe Reymond, Olivier Brina, Michel Muster, Karl-Olof Lovblad, Karl Schaller, Philippe Bijlenga, Paolo Machi
Publié dans: Interventional Neuroradiology, 2026, ISSN 1591-0199
Éditeur: SAGE Publications
DOI: 10.1177/15910199251394476

Impact of friction force and retrieval speed on in silico mechanical thrombectomies: A sensitivity analysis

Auteurs: Mahesh S. Nagargoje, Virginia Fregona, Giulia Luraghi, Francesco Migliavacca, Demitria A Poulos, Bryan C Good, Jose Felix Rodriguez Matas
Publié dans: Computer Methods and Programs in Biomedicine, Numéro 271, 2026, ISSN 0169-2607
Éditeur: Elsevier BV
DOI: 10.1016/J.CMPB.2025.109018