Towards GEMINI: A Generation of Multi-scale Digital Twins of Ischaemic and Haemorrhagic Stroke Patients

Informazioni relative al progetto

GEMINI

ID dell’accordo di sovvenzione: 101136438

DOI

10.3030/101136438

Data della firma CE 23 Novembre 2023

Data di avvio 1 Dicembre 2023

Data di completamento 30 Novembre 2029

Finanziato da

• Health

Costo totale

€ 9 991 877,50

Contributo UE

€ 9 991 877,50

Coordinato da

STICHTING AMSTERDAM UMC
Netherlands

CORDIS fornisce collegamenti ai risultati finali pubblici e alle pubblicazioni dei progetti ORIZZONTE.

I link ai risultati e alle pubblicazioni dei progetti del 7° PQ, così come i link ad alcuni tipi di risultati specifici come dataset e software, sono recuperati dinamicamente da .OpenAIRE .

Risultati finali

Data Management Plan (1)

Updated Data management Plan

Documents, reports (7)

Testing at scale – procedure description
Project Handbook
standards, inputs/outputs, model repository, QoI, CoU, and infrastructure to set up the generic digital twin

standards, inputs/outputs, model repository, QoI, CoU, andinfrastructure to set up the generic digital twin

VVUQ roadmap for GEMINI models
StC meeting minutes
Aetiology of clot formation and clot characteristics
Software engineering guidelines

Demonstrators, pilots, prototypes (1)

Creation of project website

Pubblicazioni

Peer reviewed articles (13)

Disentangling determinants of one-year modified Rankin scale in patients with incidentally detected solitary intracranial aneurysms

Autori: Lea Bührer, Lisa L. Richard, Alexandre Genoud, Abiram Sandralegar, Julien Haemmerli, Insa K. Janssen, Jeremy Hofmeister, Andrea Rosi, Gianmarco Bernava, Paolo Machi, Karl Schaller, Sandrine Morel, Philippe Bijlenga, Vincent L’Allinec, Sven Hirsch, Reinhard Furrer, Georg R. Spinner
Pubblicato in: Computers in Biology and Medicine, Numero 210, 2026, ISSN 0010-4825
Editore: Elsevier BV
DOI: 10.1016/J.COMPBIOMED.2026.111731

Sex differences in clot, vessel and tissue characteristics in patients with a large vessel occlusion treated with endovascular thrombectomy

Autori: Anne van der Meij; Ghislaine Holswilder; Marie Louise E Bernsen; Hendrikus JA van Os; Jeannette Hofmeijer; Fianne HM Spaander; Jasper M Martens; Ido R van den Wijngaard; Hester F Lingsma; Praneeta R Konduri; Charles BLM Majoie; Wouter J Schonewille; Diederik WJ Dippel; Nyika D Kruyt; Paul J Nederkoorn; Marianne AA van Walderveen; Marieke JH Wermer
Pubblicato in: European Stroke Journal, 2024, ISSN 2396-9881
Editore: SAGE Publications
DOI: 10.1177/23969873241231125

Computers in Biology and Medicine

Autori: Yue Hao 0002; Claudia Tersteeg; Alfons G. Hoekstra; Gábor Závodszky
Pubblicato in: Computers in Biology and Medicine, 2024, ISSN 0010-4825
Editore: Elsevier
DOI: 10.1016/J.COMPBIOMED.2024.109010

Mixed-effects additive Bayesian networks for the assessment of ruptured intracranial aneurysms: Insights from multicenter data

Autori: Matteo Delucchi, Philippe Bijlenga, Sandrine Morel, Reinhard Furrer, Isabel C. Hostettler, Mark K. Bakker, Romain Bourcier, Antti Lindgren, Svenja Maschke, Oliver Bozinov, Henry Houlden, David Werring, Ynte M. Ruigrok, Maria Wostrack, Bernhard Meyer, Marian Christoph Neidert, Sven Hirsch, Georg R. Spinner
Pubblicato in: Computers in Biology and Medicine, Numero 201, 2026, ISSN 0010-4825
Editore: Elsevier BV
DOI: 10.1016/J.COMPBIOMED.2025.111380

Impact of occluder device configurations in in-silico left atrial hemodynamics for the analysis of device-related thrombus

Autori: Carlos Albors; Jordi Mill; Andy L. Olivares; Xavier Iriart; Hubert Cochet; Oscar Camara
Pubblicato in: PLOS Computational Biology, 2024, ISSN 1553-7358
Editore: Public Library of Science
DOI: 10.1371/JOURNAL.PCBI.1011546

Unsupervised Clustering of Patients Undergoing Thoracoscopic Ablation Identifies Relevant Phenotypes for Advanced Atrial Fibrillation

Autori: Ilse Meijer; Marc M. Terpstra; Oscar Camara; Henk A. Marquering; Nerea Arrarte Terreros; Joris R. de Groot
Pubblicato in: Diagnostics, 2025, ISSN 2075-4418
Editore: MDPI
DOI: 10.3390/DIAGNOSTICS15101269

Clinical image analysis to build patient-specific models of acute ischemic stroke patients

Autori: Virginia Fregona; Ilaria Bottini; Sara Barati; Amedeo Cervo; Antonio Macera; Ghil Schwarz; Guglielmo Pero; Mariangela Piano; Gabriele Dubini; Jose Felix Rodriguez Matas; Giulia Luraghi; Francesco Migliavacca
Pubblicato in: Physical and Engineering Sciences in Medicine, 2025, ISSN 2662-4729
Editore: Springer Nature
DOI: 10.1007/S13246-025-01646-7

The Role of Anticoagulants After Left Atrial Appendage Occlusion

Autori: Maria Segarra-Queralt, Marc Molla, Manal Barrouhou, Andy L. Olivares, Carlos Albors, Gabriel Bernardino, Ander Regueiro, Jordi Mill, Òscar Càmara, Xavier Freixa
Pubblicato in: JACC: Case Reports, Numero 30, 2026, ISSN 2666-0849
Editore: Elsevier BV
DOI: 10.1016/J.JACCAS.2025.105838

Impact of thrombus composition on virtual thrombectomy procedures using human clot analogues mechanical data

Autori: Virginia Fregona, Giulia Luraghi, Behrooz Fereidoonnezhad, Frank J.H. Gijsen, Charles B.L.M. Majoie, Jose Felix Rodríguez Matas, Francesco Migliavacca
Pubblicato in: Journal of the Mechanical Behavior of Biomedical Materials, Numero 163, 2025, ISSN 1751-6161
Editore: Elsevier BV
DOI: 10.1016/J.JMBBM.2025.106886

Frontiers in Neurology

Autori: Olszewski, Wiktor; Cavalcante, Fabiano; van Poppel, Laura; Beenen, Ludo; Emmer, Bart J.; van den Wijngaard, Ido; Lemmens, Robin; Roos, Yvo; Marquering, Henk; Konduri, Praneeta; Majoie, Charles
Pubblicato in: Frontiers in Neurology, 2025, ISSN 1664-2295
Editore: Frontiers SA
DOI: 10.3389/FNEUR.2025.1698480

Digital twin integrating clinical, morphological and hemodynamic data to identify stroke risk factors

Autori: Saiz-Vivó, Marta; Mill, Jordi; Iriart, Xavier; Cochet, Hubert; Piella, Gemma; Sermesant, Maxime; Camara, Oscar
Pubblicato in: npj Digital Medicine, 2025, ISSN 2398-6352
Editore: Nature portfolio
DOI: 10.21203/RS.3.RS-5206065/V1

Endovascular treatment of unruptured intracranial aneurysms at a single center: Outcomes, selection strategy, and transparent communication for patient decision-making

Autori: Gianmarco Bernava, Abiram Sandralegar, Jeremy Hofmeister, Andrea Rosi, Hasan Yilmaz, Sandrine Morel, Philippe Reymond, Olivier Brina, Michel Muster, Karl-Olof Lovblad, Karl Schaller, Philippe Bijlenga, Paolo Machi
Pubblicato in: Interventional Neuroradiology, 2026, ISSN 1591-0199
Editore: SAGE Publications
DOI: 10.1177/15910199251394476

Impact of friction force and retrieval speed on in silico mechanical thrombectomies: A sensitivity analysis

Autori: Mahesh S. Nagargoje, Virginia Fregona, Giulia Luraghi, Francesco Migliavacca, Demitria A Poulos, Bryan C Good, Jose Felix Rodriguez Matas
Pubblicato in: Computer Methods and Programs in Biomedicine, Numero 271, 2026, ISSN 0169-2607
Editore: Elsevier BV
DOI: 10.1016/J.CMPB.2025.109018