Periodic Reporting for period 1 - STAGE (An Integrated Life-Course Approach for Person-Centred Solutions and Care for Ageing with Multi-morbidity in the European Regions - STAGE; Stay Healthy Through Ageing)
Periodo di rendicontazione: 2024-01-01 al 2025-06-30
Ageing is a natural and inevitable part of being human, which begins from the moment we are born. The key to ageing well is being able to continue to live our lives to the full and according to our values, ensuring we can work, spend time with our friends and family, and have quality social interaction and leisure time. As the population ages, there are challenges and barriers but also opportunities to stay healthy through ageing. Due to demographic changes, we are reaching a tipping point where the healthy life years expectancy is stagnating and may be reduced. We are also facing unprecedented health inequalities where people and new generations do not share the same opportunities to live long, healthy lives. While we age, health is becoming harder to maintain. We are seeing the emergence of multi-morbidity patterns strongly rooted in the epidemic of non-communicable diseases. Once established, these patterns are challenging to untangle. Prevalence is increasing, and the age range is broadening. Older people are often assumed to be frail or dependent and a burden to society. Such ageist attitudes and stigmatisation can lead to discrimination and worsen inequalities, affecting the opportunities older people have to age healthily. Ageing populations can also have a societal effect, including, for example, slower economic growth due to a shrinking workforce and increased pressure on public finances for pensions and healthcare. Ageing is the process of becoming older, defined by time-related deterioration of the physical and mental functions needed to survive and reproduce. Beyond biological changes, ageing is often associated with other life transitions such as retirement, housing relocation and losing friends and partners (from the WHO Fact Sheet Ageing and Health). A person’s capacity to age and stay healthy through ageing is rooted in multiple known and still-to-be-understood processes that begin as soon as we are conceived and continue across the life-course
To promote healthy ageing, we need to understand and identify the barriers and resources that influence age-related diseases, enabling timely prevention and effective treatment when needed. To address the call for person-centered health and care in the European regions, STAGE aims to demonstrate the importance and feasibility of a life-course approach to prevent accelerated ageing, as defined by the accumulation of multi-morbidity, and to integrate the knowledge into transferable person-centered solutions for early diagnosis and screening, treatment and long-term management of multi-morbidity. The ultimate aim is to add healthier years to people’s lives.
STAGE is therefore:
• Researching the root causes of unhealthy ageing by:
• Studying and interrogating the ethical, historical and societal barriers hindering healthy ageing through the life-course;
• Mapping the geographical and architectural structure of European environments to define and develop a healthy ageing index and atlas;
• Questioning the life-course and generational trajectories of multi-morbidity in cohorts and biobanks;
• Investigating the molecular hallmarks of ageing.
STAGE is working responsibly with findable, accessible, interoperable and reusable (FAIR) data from human populations to:
• Design open-source artificial intelligence (AI)-based methods for healthcare, based on guidelines for trustworthy and deployable AI in healthcare, to predict multi-morbidity trajectories;
• Continue sustaining and managing access to FAIR European health and environmental data catalogues;
• Demonstrate how European health and environmental data catalogues can integrate environmental and economic models to inform policy making.
STAGE is using its business and academic partnership to:
• Build a digital platform integrating person-centered applications and tools for prevention and care which reduce the risk of multi-morbidity through ageing;
• Ascertain the possibility of embedding these digital solutions into life-course informed prevention programmes and clinical practice.
To promote healthy ageing, we need to understand and identify the barriers and resources that influence age-related diseases, enabling timely prevention and effective treatment when needed. To address the call for person-centered health and care in the European regions, STAGE aims to demonstrate the importance and feasibility of a life-course approach to prevent accelerated ageing, as defined by the accumulation of multi-morbidity, and to integrate the knowledge into transferable person-centered solutions for early diagnosis and screening, treatment and long-term management of multi-morbidity. The ultimate aim is to add healthier years to people’s lives.
STAGE is therefore:
• Researching the root causes of unhealthy ageing by:
• Studying and interrogating the ethical, historical and societal barriers hindering healthy ageing through the life-course;
• Mapping the geographical and architectural structure of European environments to define and develop a healthy ageing index and atlas;
• Questioning the life-course and generational trajectories of multi-morbidity in cohorts and biobanks;
• Investigating the molecular hallmarks of ageing.
STAGE is working responsibly with findable, accessible, interoperable and reusable (FAIR) data from human populations to:
• Design open-source artificial intelligence (AI)-based methods for healthcare, based on guidelines for trustworthy and deployable AI in healthcare, to predict multi-morbidity trajectories;
• Continue sustaining and managing access to FAIR European health and environmental data catalogues;
• Demonstrate how European health and environmental data catalogues can integrate environmental and economic models to inform policy making.
STAGE is using its business and academic partnership to:
• Build a digital platform integrating person-centered applications and tools for prevention and care which reduce the risk of multi-morbidity through ageing;
• Ascertain the possibility of embedding these digital solutions into life-course informed prevention programmes and clinical practice.
During its first period, STAGE achieved for example the following:
• Identified and mapped the ethical, legal, and social aspects to consider in future healthy ageing interventions.
• Defined and tested, through participatory approaches, the initial features for a neighbourhood Healthy Ageing Index.
• Prepared a handbook including protocols for studying multi-morbidity in STAGE.
• Inventoried hallmarks of ageing from the literature and across European cohorts.
• Co-designed AI and technology integration for person-centered prevention and care through co-creation and Public & Patient Involvement (PPI).
• Prepared protocols for two large clinical studies in Germany and Finland to pilot person-centered applications for preventing ageing with multi-morbidity in large longitudinal life-course cohorts.
• Customised and launched two mobile applications for deployment in the KORA Digital-Fit pilot study and the Northern Finland Birth Cohort study.
• Designed an integration architecture connecting AI-based prediction models, personalised decision-support tools, and patient-facing apps.
• Defined requirements for FAIR data management and integrated STAGE FAIR data points.
• Developed key communication and dissemination resources, including the project website, social media accounts, branding, brochures, illustrations, and templates.
• Organised the Ageing Deal launch event.
• Identified and mapped the ethical, legal, and social aspects to consider in future healthy ageing interventions.
• Defined and tested, through participatory approaches, the initial features for a neighbourhood Healthy Ageing Index.
• Prepared a handbook including protocols for studying multi-morbidity in STAGE.
• Inventoried hallmarks of ageing from the literature and across European cohorts.
• Co-designed AI and technology integration for person-centered prevention and care through co-creation and Public & Patient Involvement (PPI).
• Prepared protocols for two large clinical studies in Germany and Finland to pilot person-centered applications for preventing ageing with multi-morbidity in large longitudinal life-course cohorts.
• Customised and launched two mobile applications for deployment in the KORA Digital-Fit pilot study and the Northern Finland Birth Cohort study.
• Designed an integration architecture connecting AI-based prediction models, personalised decision-support tools, and patient-facing apps.
• Defined requirements for FAIR data management and integrated STAGE FAIR data points.
• Developed key communication and dissemination resources, including the project website, social media accounts, branding, brochures, illustrations, and templates.
• Organised the Ageing Deal launch event.
The project works to deliver key exploitable results that address some of the expected needs of ageing Europe. This will include:
1) Creating Recommendations to integrate life-course approach for healthy ageing, age-friendly and equal societies.
2) Designing an age-friendly neighbourhood atlas, containing neighbourhood characteristics related to healthy and active ageing.
3) Producing scientific outputs towards understanding the types of ageing with multi-morbidity and biological ageing. We aim to understand the life course processes, taking into account the causal and social mechanisms as well as the economic impact.
4) Developing trustworthy and robust artificial intelligence (AI) tools for digital health care pathways.
5) Co-creating integrative digital platform for person-centred solutions and care.
6) Proving solutions and tools for sharing and manage FAIR life-course data (cohorts and environmental maps).
7) Building an online healthy ageing platform for knowledge sharing and for testing innovative ideas.
Via these results we aim to have an impact on the following areas:
• Reduce the non-communicable diseases (NCDs) and multi-morbidity in the older people of the future.
• Reduce the economic and healthcare costs of NCDs and multi-morbidity in the ageing population.
• Increase the proportion of older people staying in employment.
• Inform the development of policies and services to prevent and treat NCDs and multi-morbidity.
• Empower and enable citizens to adopt healthier lifestyles, including in old age.
• Promote equity on the older population and lead to a more inclusive society.
1) Creating Recommendations to integrate life-course approach for healthy ageing, age-friendly and equal societies.
2) Designing an age-friendly neighbourhood atlas, containing neighbourhood characteristics related to healthy and active ageing.
3) Producing scientific outputs towards understanding the types of ageing with multi-morbidity and biological ageing. We aim to understand the life course processes, taking into account the causal and social mechanisms as well as the economic impact.
4) Developing trustworthy and robust artificial intelligence (AI) tools for digital health care pathways.
5) Co-creating integrative digital platform for person-centred solutions and care.
6) Proving solutions and tools for sharing and manage FAIR life-course data (cohorts and environmental maps).
7) Building an online healthy ageing platform for knowledge sharing and for testing innovative ideas.
Via these results we aim to have an impact on the following areas:
• Reduce the non-communicable diseases (NCDs) and multi-morbidity in the older people of the future.
• Reduce the economic and healthcare costs of NCDs and multi-morbidity in the ageing population.
• Increase the proportion of older people staying in employment.
• Inform the development of policies and services to prevent and treat NCDs and multi-morbidity.
• Empower and enable citizens to adopt healthier lifestyles, including in old age.
• Promote equity on the older population and lead to a more inclusive society.