ENgineered CArtilage from Nose for the Treatment of Osteoarthritis (ENCANTO)

Project Information

ENCANTO

Grant agreement ID: 101137315

DOI

10.3030/101137315

EC signature date 11 December 2023

Start date 1 January 2024

End date 31 December 2029

Funded under

• Health

Total cost

€ 8 363 555,00

EU contribution

€ 8 363 555,00

Coordinated by

FONDAZIONE POLICLINICO UNIVERSITARIO CAMPUS BIO MEDICO
Italy

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Deliverables

Documents, reports (2)

Definition and implementation of digital rehabilitation program and monitoring

Defined rehabilitation program with corresponding videos and detailed instructions in all languages implemented in the online platform. Digital monitoring and data acquisitionimplemented in the rehabilitation protocol on four levels: 1) ability to perform a specific task within dailyprotocol, 2) VAS pain score on daily basis, 3) traffic light system and 4)Bassett patient self-report scales for elapsed rehabilitation week.

Dissemination and Communication Plan first version

Dissemination and Communication plan report

Websites, patent fillings, videos etc. (1)

Project Website

The public website of the project.

Publications

Peer reviewed articles (14)

Looking Inwards: The Role of Self‐Care, Self‐Management and Self‐Healing in Musculoskeletal Pain

Author(s): Joyce McSwan, Catherine E. Panwar, Ali Mobasheri
Published in: Musculoskeletal Care, Issue 23, 2025, ISSN 1478-2189
Publisher: Wiley
DOI: 10.1002/MSC.70169

White paper – A proposal towards objective biomechanical metrics as novel endpoints to document improvements in musculoskeletal function and mobility

Author(s): Sónia A. Alves, Nicholas M. Brisson, Alison N. Agres, Mark Heyland, Ali Mobasheri, David J. Hunter, Tobias Winkler, Georg N. Duda
Published in: Osteoarthritis and Cartilage Open, Issue 7, 2025, ISSN 2665-9131
Publisher: Elsevier BV
DOI: 10.1016/J.OCARTO.2025.100648

Omics-driven insights into the molecular pathways driving osteoarthritis pathogenesis

Author(s): Paco Mattheus Jacobus Welsing, Said el Bouhaddani, Lin Zhu, Nienke C. Nijhof, Simon C. Mastbergen, Chunyi Wen, Jaume Bacardit, Cristina Ruiz-Romero, Francisco J. Blanco, Ali Mobasheri
Published in: Connective Tissue Research, Issue 66, 2026, ISSN 0300-8207
Publisher: Informa UK Limited
DOI: 10.1080/03008207.2025.2541291

White paper – A proposal towards objective biomechanical metrics as novel endpoints to document improvements in musculoskeletal function and mobility

Author(s): Sónia A. Alves, Nicholas M. Brisson, Alison N. Agres, Mark Heyland, Ali Mobasheri, David J. Hunter, Tobias Winkler, Georg N. Duda
Published in: Osteoarthritis and Cartilage Open, Issue 7, 2025, ISSN 2665-9131
Publisher: Elsevier BV
DOI: 10.1016/J.OCARTO.2025.100648

Bone health and pregnancy: Osteoporosis and beyond

Author(s): Ali Mobasheri, Jean-Yves Reginster, Manju Chandran, Joyce McSwan
Published in: Case Reports in Women's Health, Issue 47, 2025, ISSN 2214-9112
Publisher: Elsevier BV
DOI: 10.1016/J.CRWH.2025.E00725

Insights into chondrocyte populations in cartilaginous tissues at the single-cell level

Author(s): Csaba Matta, Roland Takács, Mona Dvir-Ginzberg, Stephen M. Richardson, Karoliina Pelttari, Girish Pattappa, Makarand V. Risbud, Ali Mobasheri
Published in: Nature Reviews Rheumatology, Issue 21, 2025, ISSN 1759-4790
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S41584-025-01275-0

Integrative spatially resolved proteomic and metabolomic imaging reveals synovitis endotypes implicated in osteoarthritis progression

Author(s): Lin Zhu, Xin Diao, Chenrui Yuan, Chun Man Lawrence Lau, Jianing Wang, Wenlong Wu, Ali Mobasheri, Xavier Houard, Chunyi Wen, Zongwei Cai
Published in: Theranostics, Issue 15, 2025, ISSN 1838-7640
Publisher: Ivyspring International Publisher
DOI: 10.7150/THNO.117788

Disruption of the microenvironmental ecosystem in subchondral bone marrow lesions: Roles in osteoarthritis pathophysiology, pain and progression

Author(s): Ali Mobasheri, João Henriques, Jamie E. Collins
Published in: Osteoarthritis Imaging, Issue 6, 2026, ISSN 2772-6541
Publisher: Elsevier BV
DOI: 10.1016/J.OSTIMA.2025.100374

Gene therapy pipelines for osteoarthritis: current innovations, operational challenges, and future directions

Author(s): Valtteri Peitso, Karman Ng, Ron Ellis, Jean-Yves Reginster, Christopher H. Evans, Ali Mobasheri
Published in: Connective Tissue Research, 2025, ISSN 0300-8207
Publisher: Informa UK Limited
DOI: 10.1080/03008207.2025.2520319

Clinical relevance of engineered cartilage maturation in a randomized multicenter trial for articular cartilage repair

Author(s): Marcus Mumme, Anke Wixmerten, Alan Ivkovic, Giuseppe M. Peretti, Tayfun Yilmaz, Stephan Reppenhagen, Oliver Pullig, Sylvie Miot, Kaywan Izadpanah, Marcel Jakob, Laura Mangiavini, Corrado Sosio, Filip Vuletić, Oliver Bieri, Stefano Biguzzi, Brigitta Gahl, Gyözö Lehoczky, Rudolf Vukojevic, Sebastian Häusner, Anna Gryadunova, Martin Haug, Andrea Barbero, Ivan Martin
Published in: Science Translational Medicine, Issue 17, 2025, ISSN 1946-6234
Publisher: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/SCITRANSLMED.ADS0848

Rapidly progressive osteoarthritis (RPOA) in companion animals treated with bedinvetmab (Librela™): an expected pathophysiological phenomenon or a cause for concern?

Author(s): Ali Mobasheri, Peter Hanson, Jonathan Larkin
Published in: Frontiers in Veterinary Science, Issue 12, 2025, ISSN 2297-1769
Publisher: Frontiers Media SA
DOI: 10.3389/FVETS.2025.1640217

Gene therapy pipelines for osteoarthritis: current innovations, operational challenges, and future directions

Author(s): Valtteri Peitso, Karman Ng, Ron Ellis, Jean-Yves Reginster, Christopher H. Evans, Ali Mobasheri
Published in: Connective Tissue Research, Issue 66, 2026, ISSN 0300-8207
Publisher: Informa UK Limited
DOI: 10.1080/03008207.2025.2520319

Next-generation therapies for osteoarthritis: the evolving role of cell therapy products

Author(s): Valtteri Peitso, Ron Ellis, Karman Ng, Simone Ponta, Rana Smaida, Nadia Benkirane-Jessel, Nancy P. Duarte-Delgado, Tobias Winkler, Goncalo Barreto, Jean-Yves Reginster, Ali Mobasheri
Published in: Experimental & Molecular Medicine, Issue 58, 2026, ISSN 2092-6413
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/S12276-026-01726-Y

Emerging concepts in osteoarthritis and musculoskeletal diseases: Insights from the University of Debrecen Musculoskeletal Symposium 2025

Author(s): Patrik Kovács, Judit Vágó, Ali Mobasheri, Zsuzsa Jenei-Lanzl, Frank Zaucke, Henning Madry, László Csernoch, Zoltán Szekanecz, Zsuzsa Szondy, Árpád Szöőr, Istvan Szatmari, Tamás Oláh, Csaba Matta
Published in: Osteoarthritis and Cartilage Open, Issue 8, 2026, ISSN 2665-9131
Publisher: Elsevier BV
DOI: 10.1016/J.OCARTO.2025.100728

Conference proceedings (2)

Nose to knee. State of Art in clinical application of GMP products of nasal chondrocytes

Author(s): Marcus Mumme
Published in: TERMIS EU 2025 Freiburg
Publisher: N/A

Early Osteoarthritic Lesions: A Therapeutic Dead-End or an Opportunity?

Author(s): Marcus Mumme
Published in: Annual Congress Swiss Orthopaedics Zurich, 2025
Publisher: N/A